DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT1 and CCT8

DIOPT Version :9

Sequence 1:	NP_524450.2	Gene:	CCT1 / 42649	FlyBaseID:	FBgn0003676	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_610418.1	Gene:	CCT8 / 35882	FlyBaseID:	FBgn0284436	Length:	546	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	150/522 - (28%)
Similarity:	265/522 - (50%)	Gaps:	36/522 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILRLLEVEHPAAKVLVELAQLQDE 87
            :|:.|....:..::|:.||.|::||:::.|....||:|..||:|.|:|||||||::|..:|:||.
  Fly    31 RNISACKEFAQTMRSAYGPNGMNKMIINHIEKQFVTSDAGTIMRELDVEHPAAKLIVMASQMQDA 95

  Fly    88 EVGDGTTSVVILAAELLKNADELVKQKIHPTSIISGYRIACKEACKYISEHLTAPVDELGR-DSL 151
            ||||||..||:||..||::|:||::..|....|..||..|.::|.:.:...::..:::... :.:
  Fly    96 EVGDGTNFVVVLAGALLESAEELLRLGITTAEISDGYEKALEKALEILPNLVSHKIEDYRNVEKV 160

  Fly   152 INIAKTSMSSKIIGADAEFFSAMVVDAAQSVKITDPRGQAAYSIKAINVLKAHGKSARESVLIPG 216
            ..:.:||:.||..|.: :|.:.:|..|..|: :.|   :..:::..|.:.|..|....:|.::.|
  Fly   161 KEVLRTSIMSKQYGQE-DFLNDLVSKACVSI-LPD---EGTFNVDNIRICKILGSGLTKSEVVRG 220

  Fly   217 YALNCTIASQQMPKKIV--------NAKIACLDFSLQKTKMKMGVQVLINDPDKLEAIRARELDI 273
            ...          |:.|        .|||......:...:.:....|||...|:|.:..:.|..:
  Fly   221 MVF----------KRFVEGDVTYAEKAKIVIFSCPVDIIQTETKGTVLIKSADELLSFSSGEESL 275

  Fly   274 TKERINMILGTGVNVVLVSGGVDDLCMKYFVEAGAMAVRRVKKSDLKIIAKATGAAFITSLTNMD 338
            .:.:|..|...||.||:..|.|.|:.:.:..:.|.||||...|.||:.::::..|..:..:|...
  Fly   276 LESQIKAIADAGVKVVVAGGKVGDMALHFLNKYGLMAVRLNSKFDLRRLSRSVNATVLPRITTPS 340

  Fly   339 GEESFDASMVGEAAEVAQERICDDELILIKGT-KARAAASIILRGPNDFYCDEMERSVHDALCVV 402
            .||      :|...:|..|.:.|..::..:.. |....|::::||..|.:.|::||::.||:...
  Fly   341 QEE------LGYCDKVCIEELGDTTIVAFRNEGKDSRIATVVIRGATDNFMDDIERALDDAINNF 399

  Fly   403 KRVLESKKVVAGGGCVEAALSIYLENFATSLASREQLAIAEFAKSLLVIPKTLSVNAAKDATDLV 467
            |.:....:.:.|.|..|..|:..|..:|.:|...:|.|:.:||.:|.|.||.|:.|:..:.|::|
  Fly   400 KCLTRDGRYLPGAGATEIELATQLSAYADTLPGLDQYAVRKFANALEVFPKALAENSGINGTEIV 464

  Fly   468 AKLRSYHNSSQTKPERSDLKWTGLDLIEGVVRDNKKAGVLEPAMSKIKSLKFATEAAITILRIDD 532
            .:|...||:...|....|::......|     |..||.:.:...||...||:|..||.|||::|.
  Fly   465 NQLYLAHNNEAGKTIGFDIEAEKASTI-----DTTKAKLFDLYQSKFWGLKYAVGAAATILKVDQ 524

  Fly   533 MI 534
            :|
  Fly   525 II 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	150/522 (29%)
CCT8	NP_610418.1	TCP1_theta	20..529	CDD:239457	150/522 (29%)
CCT8	NP_610418.1	Cpn60_TCP1	40..529	CDD:278544	148/513 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453435
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11353
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940