DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT1 and cct5

DIOPT Version :9

Sequence 1:	NP_524450.2	Gene:	CCT1 / 42649	FlyBaseID:	FBgn0003676	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_997778.1	Gene:	cct5 / 322258	ZFINID:	ZDB-GENE-030131-977	Length:	541	Species:	Danio rerio

Alignment Length:	538	Identity:	170/538 - (31%)
Similarity:	280/538 - (52%)	Gaps:	47/538 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 TRQSGASVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILRLLEVEHPAAKV 77
            :|.:|......:::||.:::|.:::||||.|||||:||..|:|||||||||||.:::|:|..||:
Zfish    26 SRLTGLEALKSHILAAKAVANTLRTSLGPNGLDKMMVDKDGEVTVTNDGATILSMMDVDHQIAKL 90

  Fly    78 LVELAQLQDEEVGDGTTSVVILAAELLKNADELVKQKIHPTSIISGYRIACKEACKYISEHL--- 139
            :|||::.||:|:|||||.||:||..||:.|::|:.:.|||..|..||    .:|.|...|.|
Zfish    91 MVELSKSQDDEIGDGTTGVVVLAGALLEQAEQLLDRGIHPIRIADGY----DQAAKIAIEQLDKI 151

  Fly   140 --TAPVDELGRDSLINIAKTSMSSKIIGADAEFFSAMVVDAAQSV-----KITDPRGQAAYSIKA 197
              :.|||....:||:..|.|::.||:|.......:.:.|:|..:|     |..|
Zfish   152 GDSFPVDPNNTESLVQTAMTTLGSKVINRCHRQMAEIAVNAILTVADMERKDVD----------- 205

  Fly   198 INVLKAHGK---SARESVLIPGYALNCTIASQQMPKKIVNAKIACLDFSLQKTKMKMGVQVLIND 259
            ..::|..||   ...::.||.|..::...:..||||.:.:.|||.|....:..|.|...::.:..
Zfish   206 FELIKVEGKVGGKLEDTQLIKGVIVDKEFSHPQMPKVLKDTKIAILTCPFEPPKPKTKHKLDVTS 270

  Fly   260 PDKLEAIRARELDITKERINMILGTGVNVVLVSGGVDDLCMKYFVEAGAMAVRRVKKSDLKIIAK 324
            .:..:|::..|.|..:|.|..:...|.|:.:...|.||......::....|:|.|...::::||.
Zfish   271 VEDYKALQKYEKDKFQEMIRQVKENGANLAICQWGFDDEANHLLLQNELPAIRWVGGPEIELIAI 335

  Fly   325 ATGAAFITSLTNMDGEESFDASMVGEAAEVAQERIC----DDELILIKGTKARAAASIILRGPND 385
            |||...:.....:..|:...|.:|.|        ||    .|.:::|:..|...|.:|.:||.|.
Zfish   336 ATGGRIVPRFCELTPEKLGTAGLVKE--------ICFGTTKDRMLVIEECKNSRAVTIFIRGGNK 392

  Fly   386 FYCDEMERSVHDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQLAIAEFAKSLLV 450
            ...:|.:|::||||||::.::...::|.|||..|.|.::.:...|....|.||.|:..||.:|.|
Zfish   393 MIIEEAKRALHDALCVIRNLVRDNRIVYGGGASEIACALAVNEAADKCPSLEQYAMRAFADALEV 457

  Fly   451 IPKTLSVNAAKDATDLVAKLRSYHNSSQTKPERSDLKWTGLDLIEGVVRDNKKAGVLEPAMSKIK 515
            ||..|:.|:..:....:.::|    :.|.|...|.|   |:|.:.....|.|:..|:|..:.|.:
Zfish   458 IPMALAENSGLNPIQTMTEVR----ARQVKENNSAL---GIDCLHLSTNDMKQQHVIETLIGKKQ 515

  Fly   516 SLKFATEAAITILRIDDM 533
            .:..||:....||:|||:
Zfish   516 QISLATQVVKMILKIDDI 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	170/538 (32%)
cct5	NP_997778.1	TCP1_epsilon	10..535	CDD:239455	170/538 (32%)
cct5	NP_997778.1	Cpn60_TCP1	44..533	CDD:278544	165/518 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820