DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT1 and tcp1

DIOPT Version :9

Sequence 1:	NP_524450.2	Gene:	CCT1 / 42649	FlyBaseID:	FBgn0003676	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_571305.1	Gene:	tcp1 / 30477	ZFINID:	ZDB-GENE-990714-24	Length:	556	Species:	Danio rerio

Alignment Length:	553	Identity:	410/553 - (74%)
Similarity:	477/553 - (86%)	Gaps:	1/553 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SPLSIAGTRQSGASVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILRLLEV 70
            ||||:.|.|.:|.|||:||||||.||:||||||||||||||||||||||||:||||||||:||||
Zfish     4 SPLSVLGQRTTGESVRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEV 68

  Fly    71 EHPAAKVLVELAQLQDEEVGDGTTSVVILAAELLKNADELVKQKIHPTSIISGYRIACKEACKYI 135
            ||||||||.|||:|||:|||||||||||:||||||:|||||||||||||||||||:|||||.:||
Zfish    69 EHPAAKVLCELAELQDKEVGDGTTSVVIIAAELLKSADELVKQKIHPTSIISGYRLACKEAVRYI 133

  Fly   136 SEHLTAPVDELGRDSLINIAKTSMSSKIIGADAEFFSAMVVDAAQSVKITDPRGQAAYSIKAINV 200
            :|:||...|:|||:.|:|.|||||||||||.|||||:.||||||.:||..|.:|.|.|.|.::||
Zfish   134 NENLTIGTDDLGRECLLNAAKTSMSSKIIGVDAEFFANMVVDAAVAVKFVDGKGVARYPINSVNV 198

  Fly   201 LKAHGKSARESVLIPGYALNCTIASQQMPKKIVNAKIACLDFSLQKTKMKMGVQVLINDPDKLEA 265
            |||||:|.:||.|:.|||||||:.||.|.|::.|||||||||||||||||:||||:||||:||:.
Zfish   199 LKAHGRSQKESFLVNGYALNCTVGSQGMVKRVANAKIACLDFSLQKTKMKLGVQVVINDPEKLDQ 263

  Fly   266 IRARELDITKERINMILGTGVNVVLVSGGVDDLCMKYFVEAGAMAVRRVKKSDLKIIAKATGAAF 330
            ||.||.||||||:..||.:|.||||.:||:||:|:||||:.||||||||.|.|||.|||||||..
Zfish   264 IRQRESDITKERVQKILASGANVVLTTGGIDDMCLKYFVDVGAMAVRRVLKKDLKRIAKATGATV 328

  Fly   331 ITSLTNMDGEESFDASMVGEAAEVAQERICDDELILIKGTKARAAASIILRGPNDFYCDEMERSV 395
            .:||:|::|||:|:.||:|:|.||.|||:|||||||||.||||.:|||||||.|||.|||||||:
Zfish   329 CSSLSNLEGEETFEPSMLGQAEEVVQERVCDDELILIKNTKARTSASIILRGANDFMCDEMERSL 393

  Fly   396 HDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQLAIAEFAKSLLVIPKTLSVNAA 460
            ||||||||||||||.||.|||.|||||||||||:|||:.|||||||||||:|||||||||:||||
Zfish   394 HDALCVVKRVLESKSVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLLVIPKTLAVNAA 458

  Fly   461 KDATDLVAKLRSYHNSSQTKPERSDLKWTGLDLIEGVVRDNKKAGVLEPAMSKIKSLKFATEAAI 525
            :|:||||||||::||.:|..|:|.:|||.||||:.|..||||:|||.||.|.|.|||||||||||
Zfish   459 QDSTDLVAKLRAFHNEAQVNPDRKNLKWIGLDLVNGKPRDNKQAGVYEPTMVKTKSLKFATEAAI 523

  Fly   526 TILRIDDMIKLNPEDK-SGKSYADACAAGELDG 557
            |||||||:|||.|:.| .|.||.||..:|.|:|
Zfish   524 TILRIDDLIKLFPDQKEGGPSYQDAVQSGSLEG 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	396/525 (75%)
tcp1	NP_571305.1	chap_CCT_alpha	6..541	CDD:274081	400/534 (75%)
tcp1	NP_571305.1	TCP1_alpha	10..536	CDD:239451	396/525 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574690
Domainoid	1	1.000	757	1.000	Domainoid score	I86
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5656
Inparanoid	1	1.050	807	1.000	Inparanoid score	I468
OMA	1	1.010	-	-		QHG60896
OrthoDB	1	1.010	-	-		D205390at33208
OrthoFinder	1	1.000	-	-		FOG0005251
OrthoInspector	1	1.000	-	-		oto40231
orthoMCL	1	0.900	-	-		OOG6_101890
Panther	1	1.100	-	-	LDO	PTHR11353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1484
SonicParanoid	1	1.000	-	-		X3773
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	15	15.440