DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT1 and cct1

DIOPT Version :9

Sequence 1:	NP_524450.2	Gene:	CCT1 / 42649	FlyBaseID:	FBgn0003676	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_595949.1	Gene:	cct1 / 2539691	PomBaseID:	SPBC12D12.03	Length:	556	Species:	Schizosaccharomyces pombe

Alignment Length:	538	Identity:	358/538 - (66%)
Similarity:	441/538 - (81%)	Gaps:	4/538 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SPLSIAGTRQSGASVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILRLLEV 70
            |.|.::|.:.||..||.|||:|..:|:|:|||||||||||||||||||||||||||||||.||:|
pombe     8 STLFLSGEKISGEDVRNQNVLATTAIANVVKSSLGPVGLDKMLVDDIGDVTVTNDGATILSLLDV 72

  Fly    71 EHPAAKVLVELAQLQDEEVGDGTTSVVILAAELLKNADELVKQKIHPTSIISGYRIACKEACKYI 135
            ||||.||||||||.||:|||||||||||:|||||:.|:||||.|||||:||:|||:|.:||.|::
pombe    73 EHPAGKVLVELAQQQDKEVGDGTTSVVIIAAELLRRANELVKNKIHPTTIITGYRLAIREAVKFM 137

  Fly   136 SEHLTAPVDELGRDSLINIAKTSMSSKIIGADAEFFSAMVVDAAQSVKITDPRGQAAYSIKAINV 200
            ::.|:..||.||::||||:|||||||||||.|::|||.|.|||..|||.::.:|:..|.:||:|:
pombe   138 TDVLSCSVDSLGKESLINVAKTSMSSKIIGNDSDFFSTMAVDAMLSVKTSNSKGETRYPVKAVNI 202

  Fly   201 LKAHGKSARESVLIPGYALNCTIASQQMPKKIVNAKIACLDFSLQKTKMKMGVQVLINDPDKLEA 265
            |||||||:|||||:.|||||||||||.|..::.|||||.||..||||||.:||.|.|:|||:||.
pombe   203 LKAHGKSSRESVLVKGYALNCTIASQAMKTRVQNAKIAVLDMDLQKTKMALGVHVTIDDPDQLEK 267

  Fly   266 IRARELDITKERINMILGTGVNVVLVSGGVDDLCMKYFVEAGAMAVRRVKKSDLKIIAKATGAAF 330
            ||.||:.||.||:..||..|.||:|.:.|:||||:|..:|||||||||.||.||:.||||:||..
pombe   268 IREREVMITLERVKKILNAGANVILTTKGIDDLCLKSIIEAGAMAVRRCKKEDLRRIAKASGATL 332

  Fly   331 ITSLTNMDGEESFDASMVGEAAEVAQERICDDELILIKGTKARAAASIILRGPNDFYCDEMERSV 395
            ::||:|::|||:|::|.:|.|.||.||:..|||.||:|||||.::|||:|||||::..||||||:
pombe   333 LSSLSNLEGEETFESSYLGSAEEVVQEKFSDDECILVKGTKAYSSASIVLRGPNEYSLDEMERSM 397

  Fly   396 HDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQLAIAEFAKSLLVIPKTLSVNAA 460
            ||:|.||||.|||.|||.|||.||.|||||||||||||.|||||||||||::||:||:||:||||
pombe   398 HDSLSVVKRTLESGKVVPGGGAVETALSIYLENFATSLGSREQLAIAEFAQALLIIPRTLAVNAA 462

  Fly   461 KDATDLVAKLRSYHNSSQ----TKPERSDLKWTGLDLIEGVVRDNKKAGVLEPAMSKIKSLKFAT 521
            ||:|:|.||||:||.:||    |..::...|..||||:.||:|||.|||||||:|||:||||.|.
pombe   463 KDSTELTAKLRAYHAASQNAEVTDVKKRGYKNYGLDLLNGVIRDNVKAGVLEPSMSKLKSLKSAV 527

  Fly   522 EAAITILRIDDMIKLNPE 539
            ||.|.|||||..|||:||
pombe   528 EACIAILRIDTSIKLDPE 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	354/529 (67%)
cct1	NP_595949.1	chap_CCT_alpha	10..549	CDD:274081	357/536 (67%)
cct1	NP_595949.1	TCP1_alpha	14..544	CDD:239451	354/529 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	668	1.000	Domainoid score	I16
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5656
Inparanoid	1	1.050	694	1.000	Inparanoid score	I106
OMA	1	1.010	-	-		QHG60896
OrthoFinder	1	1.000	-	-		FOG0005251
OrthoInspector	1	1.000	-	-		oto101844
orthoMCL	1	0.900	-	-		OOG6_101890
Panther	1	1.100	-	-	LDO	PTHR11353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1484
SonicParanoid	1	1.000	-	-		X3773
TreeFam	1	0.960	-	-
	14	13.860