DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT1 and cct3

DIOPT Version :9

Sequence 1:	NP_524450.2	Gene:	CCT1 / 42649	FlyBaseID:	FBgn0003676	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_775357.1	Gene:	cct3 / 192327	ZFINID:	ZDB-GENE-020419-5	Length:	543	Species:	Danio rerio

Alignment Length:	543	Identity:	166/543 - (30%)
Similarity:	287/543 - (52%)	Gaps:	27/543 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RQSGASVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILRLLEVEHPAAKVL 78
            |:||..|:..|:.||.:|::|:::.|||..:.|||:|.:|.:.:||||..|||.::|:|||||.:
Zfish    15 RESGRKVQIGNISAAKTIADIIRTCLGPRAMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSM 79

  Fly    79 VELAQLQDEEVGDGTTSVVILAAELLKNADELVKQKIHPTSIISGYRIACKEACKYISEHLTAPV 143
            :|:::.||||||||||||:|||.|:|..|::.::|::|||.:|..||.|..:....:.: ::.||
Zfish    80 IEISRTQDEEVGDGTTSVIILAGEMLSVAEQFLEQQMHPTVVIGAYRQALDDMLNILKD-ISTPV 143

  Fly   144 DELGRDSLINIAKTSMSSKIIGADAEFFSAMVVDAAQSVKITDPRGQAAYSIKA-INVLKAHGKS 207
            |...||.::.|..:::::|.:...:.....:.:||.::|:: |..|:....||. ..|.|..|..
Zfish   144 DVSNRDMMLKIINSAINTKALSRWSTLACNIALDAVRTVEL-DENGREEIDIKKYAKVEKVPGGI 207

  Fly   208 ARESVLIPGYALNCTIASQQMPKKIVNAKIACLDFSLQKTKMKMGVQVLINDPDKLEAIRARELD 272
            ..:|.::.|..:|..:...:|.:.|.|.:|..||.||:..|.:....:.|...:....|...|.:
Zfish   208 IEDSCVLRGVMVNKDVTHPRMRRLIKNPRIVLLDCSLEYKKGESQTDIEIAREEDFARILQMEEE 272

  Fly   273 ITKERINMILGTGVNVVLVSGGVDDLCMKYFVEAGAMAVRRVKKSDLKIIAKATGAAFIT---SL 334
            ..::....|:....:::....|:.||...|.::|...|:||::|:|...||:|.||...:   .|
Zfish   273 YVQQICEDIIRLKPDLIFTEKGISDLAQHYLMKANITAIRRIRKTDNNRIARACGARIASRTDEL 337

  Fly   335 TNMD---GEESFDASMVGEAAEVAQERICDDELILIKGTKARAAASIILRGPNDFYCDEMERSVH 396
            |..|   |...|:...:|           |:....:...|...|.:|:|||.:.....|:||::.
Zfish   338 TENDVGTGTGLFEVKKIG-----------DEYFTFVTECKDPKACTILLRGASKEILAEVERNLQ 391

  Fly   397 DALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQLAIAEFAKSLLVIPKTLSVNAAK 461
            ||:.|.:.||....::.|||.||..:|..|...:.::...||......|::|.|:|:||..|...
Zfish   392 DAMQVCRNVLLDPYLLPGGGAVEMEVSHRLTERSRAMTGVEQWPYRAVAQALEVVPRTLIQNCGA 456

  Fly   462 DATDLVAKLRSYHNSSQTKPERSDLKWTGLDLIEGVVRDNKKAGVLEPAMSKIKSLKFATEAAIT 526
            .|..::..||:.|.      :..:..| |::...|.:.|.::.|:.||...|.::.|.|.|.||.
Zfish   457 SAIRVLTSLRAKHT------QEGNSSW-GVNGETGTLADMEQLGIWEPLAVKAQTYKTAVETAIL 514

  Fly   527 ILRIDDMIKLNPEDKSGKSYADA 549
            :|||||::..:.:...|:....|
Zfish   515 LLRIDDIVSGHKKKGDGEQTGGA 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	164/530 (31%)
cct3	NP_775357.1	chap_CCT_gamma	5..528	CDD:274085	164/532 (31%)
cct3	NP_775357.1	TCP1_gamma	5..524	CDD:239453	164/528 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810