Protein Alignment CCT1 and CCT2

DIOPT Version :10

• Sequence 1: NP_524450.2
• Gene: CCT1 / 42649
• FlyBaseID: FBgn0003676
• Length: 557
• Species: Drosophila melanogaster
• Sequence 2: NP_006422.1
• Gene: CCT2 / 10576
• HGNCID: 1615
• Length: 535
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 192/558 - (34%)
• Similarity: 314/558 - (56%)
• Gaps: 47/558 - (8%)

  Fly     1 MSTLA-SPLSI--AGTRQSGA-SVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVT--VTN 59
            |::|: :|::|  ||..:..| :.|..:.:.|::|.::|||:|||.|:||:|:....|.:  |||
Human     1 MASLSLAPVNIFKAGADEERAETARLTSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTN 65

  Fly    60 DGATILRLLEVEHPAAKVLVELAQLQDEEVGDGTTSVVILAAELLKNADELVKQKIHPTSIISGY 124
            ||||||:.:.|::|||||||:::::||:|||||||||.:||||||:.|:.|:.:||||.:||:|:
Human    66 DGATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGW 130

  Fly   125 RIACKEACKYISEHLTAPVDELG-----RDSLINIAKTSMSSKIIGADAEFFSAMVVDAAQSVKI 184
            |.|.|.|.:.:   |::.||...     |..|:|||.|::|||::....:.|:.:.|:|...:|
Human   131 REATKAAREAL---LSSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLK- 191

  Fly   185 TDPRGQAAYSIKAINVLKAHGKSARESVLIPGYALNCTIASQQMPKKIVNAKIACLDFSLQKTKM 249
                  .:.:::||:::|..|.|..:|.|..|:.|:..|...| ||:|.||||...:..:...|:
Human   192 ------GSGNLEAIHIIKKLGGSLADSYLDEGFLLDKKIGVNQ-PKRIENAKILIANTGMDTDKI 249

  Fly   250 KM-GVQVLINDPDKLEAIRARELDITKERINMILGTGVNVVLVSGGVDDLCMKYFVEAGAMAVRR 313
            |: |.:|.::...|:..|...|.:..||::..||..|:|..:....:.:...:.|..||.||:..
Human   250 KIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEH 314

  Fly   314 VKKSDLKIIAKATGAAFITS-----LTNMDGEESFDASMVGEAAEVAQERICDDELILIKGTKAR 373
            ...:.::.:|..||....::     |..:...:..:..|:||           |:||...|....
Human   315 ADFAGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGE-----------DKLIHFSGVALG 368

  Fly   374 AAASIILRGPNDFYCDEMERSVHDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQ 438
            .|.:|:|||......||.|||:||||||:.:.::..:.|.||||.|..::..:...|.....:|.
Human   369 EACTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLMAHAVTQLANRTPGKEA 433

  Fly   439 LAIAEFAKSLLVIPKTLSVNAAKDATDLVAKLRSYHNSSQTKPERSDLKWTGLDLIEGVVRDNKK 503
            :|:..:||:|.::|..::.||..|:.||||:||:.|:...|.        .|||:.||.:.|...
Human   434 VAMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGNTT--------AGLDMREGTIGDMAI 490

  Fly   504 AGVLEPAMSKIKSLKFATEAAITILRIDDMIKLNPEDK 541
            .|:.|....|.:.|..|.|||..|||:|::||..|..:
Human   491 LGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAPRKR 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	186/539 (35%)
CCT2	NP_006422.1	TCP1_beta	11..527	CDD:239452	189/545 (35%)