DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT1 and CCT2

DIOPT Version :9

Sequence 1:	NP_524450.2	Gene:	CCT1 / 42649	FlyBaseID:	FBgn0003676	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_006422.1	Gene:	CCT2 / 10576	HGNCID:	1615	Length:	535	Species:	Homo sapiens

Alignment Length:	558	Identity:	192/558 - (34%)
Similarity:	314/558 - (56%)	Gaps:	47/558 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTLA-SPLSI--AGTRQSGA-SVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVT--VTN 59
            |::|: :|::|  ||..:..| :.|..:.:.|::|.::|||:|||.|:||:|:....|.:  |||
Human     1 MASLSLAPVNIFKAGADEERAETARLTSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTN 65

  Fly    60 DGATILRLLEVEHPAAKVLVELAQLQDEEVGDGTTSVVILAAELLKNADELVKQKIHPTSIISGY 124
            ||||||:.:.|::|||||||:::::||:|||||||||.:||||||:.|:.|:.:||||.:||:|:
Human    66 DGATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGW 130

  Fly   125 RIACKEACKYISEHLTAPVDELG-----RDSLINIAKTSMSSKIIGADAEFFSAMVVDAAQSVKI 184
            |.|.|.|.:.:   |::.||...     |..|:|||.|::|||::....:.|:.:.|:|...:|
Human   131 REATKAAREAL---LSSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLK- 191

  Fly   185 TDPRGQAAYSIKAINVLKAHGKSARESVLIPGYALNCTIASQQMPKKIVNAKIACLDFSLQKTKM 249
                  .:.:::||:::|..|.|..:|.|..|:.|:..|...| ||:|.||||...:..:...|:
Human   192 ------GSGNLEAIHIIKKLGGSLADSYLDEGFLLDKKIGVNQ-PKRIENAKILIANTGMDTDKI 249

  Fly   250 KM-GVQVLINDPDKLEAIRARELDITKERINMILGTGVNVVLVSGGVDDLCMKYFVEAGAMAVRR 313
            |: |.:|.::...|:..|...|.:..||::..||..|:|..:....:.:...:.|..||.||:..
Human   250 KIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEH 314

  Fly   314 VKKSDLKIIAKATGAAFITS-----LTNMDGEESFDASMVGEAAEVAQERICDDELILIKGTKAR 373
            ...:.::.:|..||....::     |..:...:..:..|:||           |:||...|....
Human   315 ADFAGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGE-----------DKLIHFSGVALG 368

  Fly   374 AAASIILRGPNDFYCDEMERSVHDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQ 438
            .|.:|:|||......||.|||:||||||:.:.::..:.|.||||.|..::..:...|.....:|.
Human   369 EACTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLMAHAVTQLANRTPGKEA 433

  Fly   439 LAIAEFAKSLLVIPKTLSVNAAKDATDLVAKLRSYHNSSQTKPERSDLKWTGLDLIEGVVRDNKK 503
            :|:..:||:|.::|..::.||..|:.||||:||:.|:...|.        .|||:.||.:.|...
Human   434 VAMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGNTT--------AGLDMREGTIGDMAI 490

  Fly   504 AGVLEPAMSKIKSLKFATEAAITILRIDDMIKLNPEDK 541
            .|:.|....|.:.|..|.|||..|||:|::||..|..:
Human   491 LGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAPRKR 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	186/539 (35%)
CCT2	NP_006422.1	TCP1_beta	11..527	CDD:239452	189/545 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoDB	1	1.010	-	-		D205390at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830