DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT1 and CCT7

DIOPT Version :9

Sequence 1:	NP_524450.2	Gene:	CCT1 / 42649	FlyBaseID:	FBgn0003676	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_006420.1	Gene:	CCT7 / 10574	HGNCID:	1622	Length:	543	Species:	Homo sapiens

Alignment Length:	550	Identity:	197/550 - (35%)
Similarity:	298/550 - (54%)	Gaps:	35/550 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GTRQS-GASVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILRLLEVEHPAA 75
            ||..| |......|:.|...|:..|:::|||.|:||::||..|..|::|||||||:||:|.||||
Human    12 GTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVHPAA 76

  Fly    76 KVLVELAQLQDEEVGDGTTSVVILAAELLKNADELVKQKIHPTSIISGYRIACKEACKYISEHLT 140
            |.||::|:.||.|||||||||.:||||.||.....|::.:||..||..:|.|.:.|...|.|...
Human    77 KTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAV 141

  Fly   141 A--PVDELGRDSLI-NIAKTSMSSKIIGADAEFFSAMVVDAAQSVKITDPRGQAAYSIKAINVLK 202
            .  ..|::.:..|: ..|.|::|||:|.....||:.|||||   |.:.|...|    :|.|.:.|
Human   142 TVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDA---VMMLDDLLQ----LKMIGIKK 199

  Fly   203 AHGKSARESVLIPGYALNCTIA---SQQMPKKIVNAKIACLDFSLQKTKMKMGVQVLINDPDKLE 264
            ..|.:..:|.|:.|.|...|.:   .:..|||..|.|||.|:..|:....|...::.::..:..:
Human   200 VQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELELKAEKDNAEIRVHTVEDYQ 264

  Fly   265 AIRARELDITKERINMILGTGVNVVLVSGGVDDLCMKYFVEAGAMAVRRVKKSDLKIIAKATGAA 329
            ||...|.:|..:::..|..:|..|||....:.|:..:||.:.......||.:.|||....|.|.:
Human   265 AIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMACGGS 329

  Fly   330 FITSLTNMDGEESFDASMVGEAAEVAQERICDDELILIKGTKARAAASIILRGPNDFYCDEMERS 394
            ..||:      .:..|.::|......:.:|..:......|.......:.||||..:.:.:|.|||
Human   330 IQTSV------NALSADVLGRCQVFEETQIGGERYNFFTGCPKAKTCTFILRGGAEQFMEETERS 388

  Fly   395 VHDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQLAIAEFAKSLLVIPKTLSVNA 459
            :|||:.:|:|.:::..||||||.:|..||.||.:::.::..::||.|..:||:|.:||:.|..||
Human   389 LHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNA 453

  Fly   460 AKDATDLVAKLRSYHNSSQTKPERSDLKWTGLDLIEGVVRDNKKAGVLEPAMSKIKSLKFATEAA 524
            ..|||:::.|||:.|....|        |.|:|:....:.||.:|.|.||||.:|.:|..|:|||
Human   454 GFDATNILNKLRARHAQGGT--------WYGVDINNEDIADNFEAFVWEPAMVRINALTAASEAA 510

  Fly   525 ITILRIDDMIKLNPEDKSGKSYADA-CAAG 553
            ..|:.:|:.|| ||     :|..|| .|||
Human   511 CLIVSVDETIK-NP-----RSTVDAPTAAG 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	189/532 (36%)
CCT7	NP_006420.1	TCP1_eta	5..525	CDD:239456	191/539 (35%)
CCT7	NP_006420.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..543		5/10 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoDB	1	1.010	-	-		D205390at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830