DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nrx-1 and NRXN2

DIOPT Version :9

Sequence 1:NP_001262840.1 Gene:Nrx-1 / 42646 FlyBaseID:FBgn0038975 Length:1847 Species:Drosophila melanogaster
Sequence 2:XP_011543672.1 Gene:NRXN2 / 9379 HGNCID:8009 Length:1715 Species:Homo sapiens


Alignment Length:1865 Identity:592/1865 - (31%)
Similarity:871/1865 - (46%) Gaps:368/1865 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 PPVVVEYRRSYRVLIVSALLVSLAASFVTLSAGFQLDGSQNSFYTFRKWY-TGLNGTLELEFKTE 135
            ||:::            .||::|||.    :.|.:..|....:..:.:|. ...:|.|....:|.
Human    12 PPLLL------------LLLLALAAR----ADGLEFGGGPGQWARYARWAGAASSGELSFSLRTN 60

  Fly   136 QPNGLVLYTDDGGTYDFFELKLVEGALRLRYNLG-GGAQIITVGRELHDGHWHKVQVLRNDEQTS 199
            ....|:||.||||..||.||.||:|.||||:.|. .....:.:...:.|..||.|.:.|:..:|:
Human    61 ATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTA 125

  Fly   200 LIVDGVSQQRSTKGK--EFQFGKFASNSDVYVGGMPNWYSSKLALLALPSVIFEPRFRGAIRNLV 262
            |.|||.::....:.|  |.|..     ||::|||:|.  ..:|:.|.|.:|.:||.|||.:.||.
Human   126 LAVDGEARAAEVRSKRREMQVA-----SDLFVGGIPP--DVRLSALTLSTVKYEPPFRGLLANLK 183

  Fly   263 YADQPGGSTRRQEIKQQRDIKCGDVPCDHGELPARERPLRGVRGGNTTDAC--ERNDPCQHGGIC 325
            ..::|                    |...|.        :|:||......|  .|| ||.:||:|
Human   184 LGERP--------------------PALLGS--------QGLRGATADPLCAPARN-PCANGGLC 219

  Fly   326 ISTDSGPI-CECRNLEYDGQYCEKEKAPSE----------------------------------- 354
            .....|.: |:|.:..:.|::|.:|:.|.|                                   
Human   220 TVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKG 284

  Fly   355 -----ATFRGTQFLSYDLGQTGAEPIVSAQDAISFYFRTRQPNGLLFYTGHGTDYLNLALRDGGV 414
                 |||:|.:|..|||..   .||.|:.|.|:..|||.|.|||:.:||...||:||:|:.|.|
Human   285 KEEFVATFKGNEFFCYDLSH---NPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAV 346

  Fly   415 SLTMGLANGKQEMHIKPSKVRFDDHQWHKVTVHRRIQEISSI-----TSFCRLVTV-VDDVYTDH 473
            .|.:.|.:|..|..::|...:|:|:.||.|.|.|.:::.:.|     .....|||: ||.:.|..
Human   347 WLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTT 411

  Fly   474 SHIAGKFTMLSSSR-VYVGGAVNPRALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKLI 537
            .:....:|||.|.. .|:||:.|...|.|:.|..||:|||:.|.:..:...|.|..|||.|...:
Human   412 GYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKM 476

  Fly   538 QVAGNLEYQCPSGDPQDPVTFTTRESHLVLPPWETGKQSSISFKFRTKEPNGIIVLATGSK---- 598
            ::.|:|.::|......|||||.:.|:.:.||.|...:..|||..|||.||||:::.:.|.:    
Human   477 KLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGG 541

  Fly   599 ---QPRAKNPVLIAIELLNGHIYIHLDLGSGASKVRASRRRVDDGDWHDLILRRNGRDAKVSVDG 660
               ...|:.....|:|||:||:|:.||:|||..|:|||.|:|:||:|..:..:|:||...:||:.
Human   542 AGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNS 606

  Fly   661 VWNDFRTPGDGTILELDGHMYLGGVGPAYNSVS--WPAAIWTATLRQGFVGCLRDLVLSGKAIDI 723
            ....|...||..||:|:..:||||: |....|.  .|..:|||.||.|:|||:|||.:.|::.|:
Human   607 RSTPFLATGDSEILDLESELYLGGL-PEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDL 670

  Fly   724 AAFARVQDSASVKPSCHVQA-NVCNGNPCLNGGTCLEGWNRPICDCSATLYGGPTCGRELATLAF 787
            ...|..|.:..|.|.|..:. ..|...||.|||.|.|||||.||||..|.:.|..|.||...|::
Human   671 RGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSY 735

  Fly   788 NGSQHMTIWLGNGQGTKTQTEELVIRFKTSRPAGLLLLTSAESNSPDRLEIALVAGRVRASVRL- 851
            :||.:|.|.|.|..  .|:.|::.:||.:.|..||::.|::. .|.|.|.:.|..|:::.:|.| 
Human   736 DGSMYMKIMLPNAM--HTEAEDVSLRFMSQRAYGLMMATTSR-ESADTLRLELDGGQMKLTVNLD 797

  Fly   852 -----------SDREKNLLAGQSVLNDNNWHTIRFSRRASNLRLQVDGAPPVRGMLSETILGRHS 905
                       ....:.|.||.. ||||.|||:|..||..:|:|.||.. .|.|.::    |.|.
Human   798 CLRVGCAPSAAGKGPETLFAGHK-LNDNEWHTVRVVRRGKSLQLSVDNV-TVEGQMA----GAHM 856

  Fly   906 TMEIRSVHLGGLFHAEEEIQMTSTMP-NFVGQMQGLVFNGQRYLDIVKSLGPELSALPSATF-KL 968
            .:|..::..|.:    .|.:..|.:| ||:|.:.|||||||.|:|..|.        ...|: :|
Human   857 RLEFHNIETGIM----TERRFISVVPSNFIGHLSGLVFNGQPYMDQCKD--------GDITYCEL 909

  Fly   969 TARF-VNSPAGQPYHAATFRSKHSYVGLAMLKAYNSISIDFRFKTVEPNGLLVFNGGRRNDFVAV 1032
            .||| :.:....|   .||:|:.||:.||.|:||.|:.:.|:|||..|:|||:||.|..|||:.:
Human   910 NARFGLRAIVADP---VTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVI 971

  Fly  1033 ELVNGHIHYTFDLGDGPVTMRDKSRIHMNDNRWHQVSIRRPGPKTHTLTVDDSFEIISLTGNNMH 1097
            |||.|:|||.||||:||..|:..|...:|||:||.|.:.|.....|||.: ||..:...:....:
Human   972 ELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKI-DSRTVTQHSNGARN 1035

  Fly  1098 LELAGILYIGGVFKDMYSKLPASISSRSGFEGCLASLDLGDASPSLTSDAVVPSSLVVSGCEGP- 1161
            |:|.|.|||||:.|:|:|.||..::||.||:|||||:||....|.|.:||:.....|..||:|| 
Human  1036 LDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPS 1100

  Fly  1162 TKCSQNACANRGNCVQQWNAYACECDMTSYTGPTCYDESIAYEFGNNKGMVQYTFPENAQADTEE 1226
            |.|::.:|||:|.|:|||:.:.|:|.||||.||.|.|....|.||....::.||:|.|.:..|..
Human  1101 TTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRM 1165

  Fly  1227 DNIALGFITTRPDAVLLRVESAT-TQDYMELEIVEGNIFMVYNIGSVDLPLGEIGTKVNDNAYHV 1290
            |.:|:||.|.:..|||:||:||: ..||::|.|.:|.:.:::|:|:.|:.:.|....|:|..|||
Human  1166 DRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHV 1230

  Fly  1291 VRFQRKGGNATLQLDDYNVQALTP------------------------------QSHHSTVFNTM 1325
            |||.|.|||||||:|.:.|....|                              :....|:||:.
Human  1231 VRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQ 1295

  Fly  1326 SNVQVGGKFSRNGRNRIERPFAGVIAGLSVNKLRILDLAVERDPHITIRGDVQLV---------- 1380
            :.:::||:..       .|||.|.::||..|.|::|.||.|.||::...|.::||          
Human  1296 AAIKIGGRDQ-------GRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSA 1353

  Fly  1381 ----TGVLDRNDLQRMQQTLNSTRQTPASGYPGAL--------DDLIFSGAGSGCRGDDED--EC 1431
                |.:|.......|:.|......|...|....|        |||:.  |.:.|..||||  ||
Human  1354 ETTATTLLADMATTIMETTTTMATTTTRRGRSPTLRDSTTQNTDDLLV--ASAECPSDDEDLEEC 1416

  Fly  1432 TPPFESGSGDDLITPV----------------YVPP-------------TKQTTTSQQGNSLSTG 1467
            .|    .:|.:||.|:                :|||             |:.|..........:|
Human  1417 EP----STGGELILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSG 1477

  Fly  1468 GSSSGGVITNGTERACDDEDC---VHGSGDYGETTEQFTSTSTARGSESNNEMVTITTTGRSDVT 1529
            |...       .||  ||.||   :..||        |.|                         
Human  1478 GPCQ-------AER--DDSDCEEPIEASG--------FAS------------------------- 1500

  Fly  1530 TEQHQGSSSSSSSGSTPSYATTQSSSSSSSGGSAASTPGQVSTTSSVATSSTQRATSSSTSTSSS 1594
                                                  |:|..:|...|......|     |...
Human  1501 --------------------------------------GEVFDSSLPPTDDEDFYT-----TFPL 1522

  Fly  1595 TTSTTTTTTTTQATPPPEIRSTVTERETTPYDIYIAGGGMG---GSGRNDH-DRMQLPDEHHPL- 1654
            .|..||..:..:..|.|.:|   |:..|....:..|.....   .:|:.:| |.:|...|:.|| 
Human  1523 VTDRTTLLSPRKPAPRPNLR---TDGATGAPGVLFAPSAPAPNLPAGKMNHRDPLQPLLENPPLG 1584

  Fly  1655 PPLPPPIPPQDPPPYGPYGGNTYN---TNMNNYRPKGKG-----GRINSIEE--ERTAMIIGIVA 1709
            |..|....|:.|||..|  |.|..   .::....|.|.|     |.:..|.|  ..|.|::||||
Human  1585 PGAPTSFEPRRPPPLRP--GVTSAPGFPHLPTANPTGPGERGPPGAVEVIRESSSTTGMVVGIVA 1647

  Fly  1710 GILIAVVLVILLVLWLKSNGDRG-YKTESEKAAAYGSHNPNAALL 1753
            ...:. :|::|..::...|.|.| |:.:..:.....|...|.|::
Human  1648 AAALC-ILILLYAMYKYRNRDEGSYQVDQSRNYISNSAQSNGAVV 1691

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nrx-1NP_001262840.1 LamG 110..263 CDD:238058 53/156 (34%)
EGF_CA 311..347 CDD:238011 12/38 (32%)
Laminin_G_2 386..517 CDD:280389 52/137 (38%)
LamG 555..716 CDD:238058 71/169 (42%)
EGF 746..777 CDD:278437 18/30 (60%)
Laminin_G_2 814..945 CDD:280389 46/143 (32%)
LamG 988..1136 CDD:238058 72/147 (49%)
EGF 1164..1195 CDD:278437 16/30 (53%)
Laminin_G_2 1233..1356 CDD:280389 48/153 (31%)
NRXN2XP_011543672.1 LamG 28..184 CDD:238058 55/162 (34%)
Laminin_G_2 318..456 CDD:280389 52/137 (38%)
LamG 516..666 CDD:214598 63/150 (42%)
EGF_CA 694..727 CDD:238011 18/32 (56%)
Laminin_G_2 760..893 CDD:280389 46/143 (32%)
Laminin_G_2 949..1077 CDD:280389 64/128 (50%)
Laminin_G_2 1172..1320 CDD:280389 48/154 (31%)
Syndecan 1640..>1679 CDD:279386 11/39 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146808
Domainoid 1 1.000 134 1.000 Domainoid score I5015
eggNOG 1 0.900 - - E1_KOG3514
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 866 1.000 Inparanoid score I427
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46386
OrthoDB 1 1.010 - - D24127at33208
OrthoFinder 1 1.000 - - FOG0001168
OrthoInspector 1 1.000 - - otm42021
orthoMCL 1 0.900 - - OOG6_103392
Panther 1 1.100 - - LDO PTHR15036
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X794
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1312.810

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