DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-1 and NRXN3

DIOPT Version :9

Sequence 1:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster
Sequence 2:	XP_011535665.1	Gene:	NRXN3 / 9369	HGNCID:	8010	Length:	1687	Species:	Homo sapiens

Alignment Length:	1827	Identity:	598/1827 - (32%)
Similarity:	904/1827 - (49%)	Gaps:	302/1827 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 LIVSALLVSLAASFVTLSAGFQLDGSQNSFYTFRKWYTGLNGTLELEFKTEQPNGLVLYTDDGGT 149
            |.||.||.||    :.|..|.:..|..|.:..:.:|.......|..:|||....||:||.||||.
Human    12 LKVSILLGSL----LGLCLGLEFMGLPNQWARYLRWDASTRSDLSFQFKTNVSTGLLLYLDDGGV 72

  Fly   150 YDFFELKLVEGALRLRYNLGGGAQIITVGRELHDGHWHKVQVLRNDEQTSLIVDGVSQQRSTKGK 214
            .||..|.||:|.::||:::......:...::::|..||.:.|.|:..:|.|::||
Human    73 CDFLCLSLVDGRVQLRFSMDCAETAVLSNKQVNDSSWHFLMVSRDRLRTVLMLDG---------- 127

  Fly   215 EFQFGKFASN-------SDVYVGGMPNWYSSKLALLALPSVIFEPRFRGAIRNLVYADQPGGSTR 272
            |.|.|:....       ||:::||:|.  ..:.:.|.|..|...|.|:|.|.:|.|.:.......
Human   128 EGQSGELQPQRPYMDVVSDLFLGGVPT--DIRPSALTLDGVQAMPGFKGLILDLKYGNSEPRLLG 190

  Fly   273 RQEIKQQRDIKCGDVPCDHGELPARERPLRGVRGGNTTDACERNDPCQHGGICISTDSGPICECR 337
            .:.::...:..||                            ||  ||::||||...|..|.|:|.
Human   191 SRGVQMDAEGPCG----------------------------ER--PCENGGICFLLDGHPTCDCS 225

  Fly   338 NLEYDGQYCEKE------------------KAPSE--ATFRGTQFLSYDLGQTGAEPIVSAQDAI 382
            ...|.|:.|.::                  ||..|  |||||:::|.|||.|   .||.|:.|.|
Human   226 TTGYGGKLCSEDVSQDPGLSHLMMSEQGRSKAREENVATFRGSEYLCYDLSQ---NPIQSSSDEI 287

  Fly   383 SFYFRTRQPNGLLFYTGHGTDYLNLALRDGGVSLTMGLANGKQEMHIKPSKVRFDDHQWHKVTVH 447
            :..|:|.|.|||:.:||...||:||||:||.|||.:.|.:|..|..::|...:|:|:.||.|.|.
Human   288 TLSFKTWQRNGLILHTGKSADYVNLALKDGAVSLVINLGSGAFEAIVEPVNGKFNDNAWHDVKVT 352

  Fly   448 RRIQEISSITSFCRLVTV-VDDVYTDHSHIAGKFTMLSSSR-VYVGGAVNPRALLGARVHTNFVG 510
            |.:::.|.|..  .:||: ||.:.|...:....:|||.|.. .||||:.:...|.|:.|..||:|
Human   353 RNLRQHSGIGH--AMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMG 415

  Fly   511 CLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQCPSGDPQDPVTFTTRESHLVLPPWETGKQ 575
            ||::|.:..:.:.|.|..||:.....:::.|.:.::|.:....||:.|.|.|:::.||.|.|.:.
Human   416 CLKEVVYKNNDIRLELSRLARIADTKMKIYGEVVFKCENVATLDPINFETPEAYISLPKWNTKRM 480

  Fly   576 SSISFKFRTKEPNGIIVLATGSKQPR-----AKNPVL--IAIELLNGHIYIHLDLGSGASKVRAS 633
            .||||.|||.||||:|:...|..|.|     .||..:  .|:|||:|::|:.||:|||..||:|:
Human   481 GSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKAT 545

  Fly   634 RRRVDDGDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTILELDGHMYLGGVGPAYNSVSWPAAI 698
            :::.:||:|:.:.::|:||...:||:.....|...|:..||:|:|.|||||:......:..|..:
Human   546 QKKANDGEWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTEL 610

  Fly   699 WTATLRQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSC-HVQANVCNGNPCLNGGTCLEGWN 762
            |||.|..|:|||:|||.:.|::.:|...|.:|::|.||.|| .:.|..|:..||.|...|.:|||
Human   611 WTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWN 675

  Fly   763 RPICDCSATLYGGPTCGRELATLAFNGSQHMTIWLGNGQGTKTQTEELVIRFKTSRPAGLLLLTS 827
            |.||||:.|.|.|.||.||.:.|:::||.:|.|.:  .....|:.|::..||.:.|..|||:.|:
Human   676 RFICDCTGTGYWGRTCEREASILSYDGSMYMKIIM--PMVMHTEAEDVSFRFMSQRAYGLLVATT 738

  Fly   828 AESNSPDRLEIALVAGRVRASVRL---------SDREKNLLAGQSVLNDNNWHTIRFSRRASNLR 883
            :. :|.|.|.:.|..|||:..|.|         |...:.|.|||. ||||.|||:|..||..:|:
Human   739 SR-DSADTLRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQK-LNDNEWHTVRVVRRGKSLK 801

  Fly   884 LQVDGAPPVRGMLSETILGRHSTMEIRSVHLGGLFHAEEEIQMTSTMP-NFVGQMQGLVFNGQRY 947
            |.||.     .:...|::|.|:.:|..::..|.:    .|.:..|.:| :|:|.:|.|:|||..|
Human   802 LTVDD-----DVAEGTMVGDHTRLEFHNIETGIM----TEKRYISVVPSSFIGHLQSLMFNGLLY 857

  Fly   948 LDIVKSLGPELSALPSATFKLTARF-VNSPAGQPYHAATFRSKHSYVGLAMLKAYNSISIDFRFK 1011
            :|:.|:...:..       :|.||| :.:....|   .||::|.||:.||.|:||.|:.:.|:||
Human   858 IDLCKNGDIDYC-------ELKARFGLRNIIADP---VTFKTKSSYLSLATLQAYTSMHLFFQFK 912

  Fly  1012 TVEPNGLLVFNGGRRNDFVAVELVNGHIHYTFDLGDGPVTMRDKSRIHMNDNRWHQVSIRRPGPK 1076
            |..|:|.::||.|..|||:|||||.|:|||.||||:||..::..|...:|||:||.|.|.|....
Human   913 TTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSN 977

  Fly  1077 THTLTVDDSFEIISLTGNNMHLELAGILYIGGVFKDMYSKLPASISSRSGFEGCLASLDLGDASP 1141
            ||:|.||... :..:.....:|:|.|.||:.|:.:.|||.||..::||.||:|||||:||....|
Human   978 THSLKVDTKV-VTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLP 1041

  Fly  1142 SLTSDAVVPSSLVVSGCEGP-TKCSQNACANRGNCVQQWNAYACECDMTSYTGPTCYDESIAYEF 1205
            .|.:||:..|..:..||||| |.|.:::|||:|.|:|||..:.|:|.||||:|..|.|....|.|
Human  1042 DLINDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYIF 1106

  Fly  1206 GNNKGMVQYTFPENAQADTEEDNIALGFITTRPDAVLLRVESAT-TQDYMELEIVEGNIFMVYNI 1269
            |.:.|::.||:|.|.:..|..|.:|:||.||..|.:|:|::||. ..|:::|.|.:|.|.:|:||
Human  1107 GKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNI 1171

  Fly  1270 GSVDLPLGEIGTKVNDNAYHVVRFQRKGGNATLQLDDYNV------------------------- 1309
            |:||:.:.|..|.|||..||||||.|.|||||||:|::.|
Human  1172 GTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGNTDNERFQMVKQKIPFKY 1236

  Fly  1310 -----QALTPQSHHSTVFNTMSNVQVGGKFSRNGRNRIERPFAGVIAGLSVNKLRILDLAVERDP 1369
                 :.|..:....|:|||.:.:.:|||    .:.|:   |.|.::||..:.|::|::|.|.:|
Human  1237 NRPVEEWLQEKGRQLTIFNTQAQIAIGGK----DKGRL---FQGQLSGLYYDGLKVLNMAAENNP 1294

  Fly  1370 HITIRGDVQL---VTGVLDRNDLQRMQQTLNST---------------RQTPASGYPGALDDLIF 1416
            :|.|.|.|:|   |..:|.......|...:::|               .::.||..|.: |||:.
Human  1295 NIKINGSVRLVGEVPSILGTTQTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTS-DDLVS 1358

  Fly  1417 SGAGSGCRGDDED--ECTPPFESG-SGDDLITPVYV------------------PPTKQ---TTT 1457
            |   :.|..||||  ||.|  .:| ||.:|:.|:.|                  |||.:   |..
Human  1359 S---AECSSDDEDFVECEP--STGRSGGELVIPLLVEDPLATPPIATRAPSITLPPTFRPLLTII 1418

  Fly  1458 SQQGNSLSTGGSSSGGVITNGTERACDDEDCV---HGSGDYGETTEQFTSTSTARGSESNNEMVT 1519
            ....:|||....:....:::.....|||:..|   :|||      |.|.|              .
Human  1419 ETTKDSLSMTSEAGLPCLSDQGSDGCDDDGLVISGYGSG------ETFDS--------------N 1463

  Fly  1520 ITTTGRSDVTTEQHQGSSSSSSSGSTPSYATTQS-SSSSSSGGSAASTPGQVSTTSSVATSSTQR 1583
            :..|...|..|              |.|..|.:| |:|...||..|..|              :.
Human  1464 LPPTDDEDFYT--------------TFSLVTDKSLSTSIFEGGYKAHAP--------------KW 1500

  Fly  1584 ATSSSTSTSSSTTSTTTTTTTTQATPPPEIRSTVTERETTPYDIYIAGGGM----GGSGRNDHDR 1644
            .:........|.||.||||:.:    |..||.|.:           :..||    .....|:.|.
Human  1501 ESKDFRPNKVSETSRTTTTSLS----PELIRFTAS-----------SSSGMVPKLPAGKMNNRDL 1550

  Fly  1645 MQLPDEHHPLPPLPPPIPPQDPPPYGPYGGNTYNTNMNNYRPKGKG-----GRINSIEE--ERTA 1702
            ...||  ..|.|||............|...:....|:....|...|     |....|.|  ..|.
Human  1551 KPQPD--IVLLPLPTAYELDSTKLKSPLITSPMFRNVPTANPTEPGIRRVPGASEVIRESSSTTG 1613

  Fly  1703 MIIGIVAGILIAVVLVILLVLWLKSNGDRG-YKTESEKAAAYGSHNPNAALLGNTSTNGSYHQQR 1766
            |::||||...:. :|::|..::...|.|.| |:.:..:     ::..|:|     .:||:..:::
Human  1614 MVVGIVAAAALC-ILILLYAMYKYRNRDEGSYQVDETR-----NYISNSA-----QSNGTLMKEK 1667

  Fly  1767 QHHMHGG 1773
            |.....|
Human  1668 QQSSKSG 1674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058	47/159 (30%)
		EGF_CA	311..347	CDD:238011	14/35 (40%)
		Laminin_G_2	386..517	CDD:280389	54/132 (41%)
		LamG	555..716	CDD:238058	70/167 (42%)
		EGF	746..777	CDD:278437	16/30 (53%)
		Laminin_G_2	814..945	CDD:280389	48/140 (34%)
		LamG	988..1136	CDD:238058	70/147 (48%)
		EGF	1164..1195	CDD:278437	16/30 (53%)
		Laminin_G_2	1233..1356	CDD:280389	53/153 (35%)
NRXN3	XP_011535665.1	LamG	35..181	CDD:238058	47/157 (30%)
		EGF	202..232	CDD:394967	15/59 (25%)
		LamG	286..425	CDD:214598	55/140 (39%)
		LamG	482..631	CDD:214598	62/148 (42%)
		EGF_CA	659..692	CDD:238011	17/32 (53%)
		LamG	720..854	CDD:214598	48/144 (33%)
		Laminin_G_2	911..1039	CDD:396680	62/128 (48%)
		LamG	1103..1282	CDD:238058	65/185 (35%)
		Syndecan	1613..>1648	CDD:395821	11/35 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I5015
eggNOG	1	0.900	-	-		E1_KOG3514
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	866	1.000	Inparanoid score	I427
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46386
OrthoDB	1	1.010	-	-		D24127at33208
OrthoFinder	1	1.000	-	-		FOG0001168
OrthoInspector	1	1.000	-	-		otm42021
orthoMCL	1	0.900	-	-		OOG6_103392
Panther	1	1.100	-	-	O	PTHR15036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X794
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840