DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-1 and CNTNAP1

DIOPT Version :9

Sequence 1:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster
Sequence 2:	NP_003623.1	Gene:	CNTNAP1 / 8506	HGNCID:	8011	Length:	1384	Species:	Homo sapiens

Alignment Length:	1306	Identity:	279/1306 - (21%)
Similarity:	452/1306 - (34%)	Gaps:	422/1306 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   357 FRGTQFLSYDLGQTGAEPIVSAQDAISFYFRTRQPNGLLFYT-GHGTDYLNLALRDGGVSLTMGL 420
            |.|...:||...:..:.   |..|..:|.|:|.:.:|||.:. |...||:.|.|.  |..|.:.:
Human   177 FDGDDAISYRFPRGVSR---SLWDVFAFSFKTEEKDGLLLHAEGAQGDYVTLELE--GAHLLLHM 236

  Fly   421 ANGKQEMHIKPSKVR------FDDHQWHKVTVHRRIQEISSITSFCRLVTVVDDVYTDHSHIAGK 479
            :.|...:..:|....      .:|..||.|.|.|          |.|.|....|.|.....:.|.
Human   237 SLGSSPIQPRPGHTTVSAGGVLNDQHWHYVRVDR----------FGRDVNFTLDGYVQRFILNGD 291

  Fly   480 FTMLS-SSRVYVGGAVNPRALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNL 543
            |..|: .:.:::||.|.......|..| ||.||:..|.|:    .:|:.|||......|...|.:
Human   292 FERLNLDTEMFIGGLVGAARKNLAYRH-NFRGCIENVIFN----RVNIADLAVRRHSRITFEGKV 351

  Fly   544 EYQCPSGDPQDPVTFTTRESHLVLPPWETGKQSSISFKFRTKEPNGIIV---LATGSKQPRAKNP 605
            .::|....|. |:.|....:.:.:|.:....:.::||:|||.:..|:::   |..|.
Human   352 AFRCLDPVPH-PINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLFSRLGDGL-------- 407

  Fly   606 VLIAIELLNGHIYIHLDLG--------SGASKVR-ASRRRVDDGDWHDLILRRNGRDAKVSVDGV 661
                     ||:.:.|..|        ||..|:: |:..|::||.||::........|.:|:|.|
Human   408 ---------GHVELTLSEGQVNVSIAQSGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDV 463

  Fly   662 WNDFRTPGDGT-------ILELDGHMYLGGVGPAYNSVSWPAAIWTATLRQ-GFVGCLRDLVLSG 718
                    :|.       :|...|..|..|..|.      ||:.|.....| .|.||:..|.:.|
Human   464 --------EGAEVRVSYPLLIRTGTSYFFGGCPK------PASRWDCHSNQTAFHGCMELLKVDG 514

  Fly   719 KAIDIAA--------FARVQDSASVKPSCHVQANVCNGNPCLNGGTCLEGWNRPICDCSATLYGG 775
            :.:::..        :|.|     :..:|.: .:.|:.|.|.:.|.|.:.|:..||.|..|.|.|
Human   515 QLVNLTLVEGRRLGFYAEV-----LFDTCGI-TDRCSPNMCEHDGRCYQSWDDFICYCELTGYKG 573

  Fly   776 PTCGRELATLAFNGSQHMTIWLGNGQGTKTQTEELVIRFKTSRPAGLLLLTSAESNSPDRLEIAL 840
            .||             |..::       |...|...:..|||   |...:      .||.
Human   574 ETC-------------HTPLY-------KESCEAYRLSGKTS---GNFTI------DPDG----- 604

  Fly   841 VAGRVRASVRLSDREKNLLAGQSVLNDNNWHTIRFSRRASNLRLQVDGAPPVRGMLSETILGRHS 905
             :|.::..|...|..:| .|...|.:|..|.|            :|.|:...|..|........|
Human   605 -SGPLKPFVVYCDIREN-RAWTVVRHDRLWTT------------RVTGSSMERPFLGAIQYWNAS 655

  Fly   906 TMEIRSVHLGGLFHAEEEIQMT---STMPNFVG-----------QMQGLVFNG-----QRYLDIV 951
            ..|: |.......|.|:.|:.:   |.:.|..|           :.|...:.|     ||.
Human   656 WEEV-SALANASQHCEQWIEFSCYNSRLLNTAGGYPYSFWIGRNEEQHFYWGGSQPGIQRC---- 715

  Fly   952 KSLGPELSALPSA-------------TFKLTARFVNS-PAGQPYHAATFRSKHS----------- 991
             :.|.:.|.:..|             |.|....||:. |..|.....|.||...
Human   716 -ACGLDRSCVDPALYCNCDADQPQWRTDKGLLTFVDHLPVTQVVIGDTNRSTSEAQFFLRPLRCY 779

  Fly   992 -----------YVGLAM----LKAYNSISIDFRFKTVEPNGLLVFNGGR-----RNDFVAVEL-V 1035
                       :.|.|:    ::|.:|:.:.|.|:|..|:|:.:.|.|.     |..:|.||| .
Human   780 GDRNSWNTISFHTGAALRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPYCQWRRPYVRVELNT 844

  Fly  1036 NGHIHYTFDLGDGPVTMRDKS-RIHMNDNRWHQVS-----------------IRRPGP-KTHTLT 1081
            :..:.:.||:|:|...:...| ....||:.||.|.                 :.||.| :|:
Human   845 SRDVVFAFDVGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDHRPWVLRPMPLQTY--- 906

  Fly  1082 VDDSFEIISLTGNNMHLELAGILYIGGVFKDMYSKLPASISSRSGFEGCLASLDLGDASPSL--- 1143
                          :.:|....||:|.          |.:..|. |.|||.::.|...:.:|
Human   907 --------------IWMEYDQPLYVGS----------AELKRRP-FVGCLRAMRLNGVTLNLEGR 946

  Fly  1144 --TSDAVVPSSLVVSGCEGPTKCSQNACANRGNCVQQWNAYACECDMTSYTGPTCYDE------- 1199
              .|:...|:      |.|.....:..|.:.|.||::::.|.|:||:|::.||.|..:
Human   947 ANASEGTSPN------CTGHCAHPRLPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFEP 1005

  Fly  1200 -------------SIAYEF---------GNNKGMVQ---------------YTFPENAQA----- 1222
                         |.|.||         |...|.:.               |..|:..:.
Human  1006 GTWMRYNLQSALRSAAREFSHMLSRPVPGYEPGYIPGYDTPGYVPGYHGPGYRLPDYPRPGRPVP 1070

  Fly  1223 -------DTEEDNIALGFITTRPDAVLLRVESATTQDYMELEIV-EGNIFMVYNIGSVDLPLGEI 1279
                   :...:.::..|.|:...||||.| |:..:|||.:.|. :|.:.:.|.:|:........
Human  1071 GYRGPVYNVTGEEVSFSFSTSSAPAVLLYV-SSFVRDYMAVLIKDDGTLQLRYQLGTSPYVYQLT 1134

  Fly  1280 GTKVNDNAYHVVRFQRKGGNATLQLDDYNVQALTPQSHHSTVFNTMSNVQVGGKFSRNGRNRIER 1344
            ...|.|...|.:...|...|..:|:|.:   .||.|                 |||....::::.
Human  1135 TRPVTDGQPHSINITRVYRNLFIQVDYF---PLTEQ-----------------KFSLLVDSQLDS 1179

  Fly  1345 PFAGVIAGLSVNKLRILDLAVERDPHITIRGDVQLVTGVLDRNDLQRMQQTLNSTRQTPASGYPG 1409
            |.|..:.       |:::                  |||:| .::||.        .||  |:.|
Human  1180 PKALYLG-------RVME------------------TGVID-PEIQRY--------NTP--GFSG 1208

  Fly  1410 ALDDLIFSGAGS-------------------GCRGD-DEDEC---------TPPFESGSGDDLIT 1445
            .|..:.|:....                   ..:|: .|..|         .||        .:.
Human  1209 CLSGVRFNNVAPLKTHFRTPRPMTAELAEALRVQGELSESNCGAMPRLVSEVPP--------ELD 1265

  Fly  1446 PVYVPP 1451
            |.|:||
Human  1266 PWYLPP 1271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058
		EGF_CA	311..347	CDD:238011
		Laminin_G_2	386..517	CDD:280389	38/138 (28%)
		LamG	555..716	CDD:238058	42/180 (23%)
		EGF	746..777	CDD:278437	12/30 (40%)
		Laminin_G_2	814..945	CDD:280389	30/149 (20%)
		LamG	988..1136	CDD:238058	41/198 (21%)
		EGF	1164..1195	CDD:278437	10/30 (33%)
		Laminin_G_2	1233..1356	CDD:280389	30/123 (24%)
CNTNAP1	NP_003623.1	FA58C	36..167	CDD:238014
		LamG	175..330	CDD:238058	45/168 (27%)
		LamG	362..513	CDD:238058	42/181 (23%)
		EGF	544..575	CDD:306513	12/30 (40%)
		FReD	584..>658	CDD:294064	21/101 (21%)
		LamG	787..937	CDD:238058	40/177 (23%)
		LamG	1083..1218	CDD:214598	43/191 (23%)
		4.1m	1304..1322	CDD:128590
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1319..1384
		SH3-binding. /evidence=ECO:0000255	1328..1369
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910