Protein Alignment Nrx-1 and pros1

DIOPT Version :9

• Sequence 1: NP_001262840.1
• Gene: Nrx-1 / 42646
• FlyBaseID: FBgn0038975
• Length: 1847
• Species: Drosophila melanogaster
• Sequence 2: NP_001119539.1
• Gene: pros1 / 733989
• XenbaseID: XB-GENE-980521
• Length: 673
• Species: Xenopus tropicalis
• Alignment Length: 522
• Identity: 100/522 - (19%)
• Similarity: 186/522 - (35%)
• Gaps: 156/522 - (29%)

  Fly    58 RFNKARRRRRSEQVPPVV-VEYRRSYRVLIVSALLVSLAASFVTLSAGFQL-DGSQNSFYTFRKW 120
            ::..|:.:...|.:|..| :....:|.:|.::.....:...::.    |:| |.|:.|
 Frog   274 KYKLAQDQTSCESIPVCVPLNLETNYELLYLAEQFTGIPVVYLR----FKLPDVSRFS------- 327

  Fly   121 YTGLNGTLELEFKTEQPNGLVLYTDDGGTYDFFELKLVEGALRLRYNLGGGAQIITVGRELHDGH 185
                   .|.:|:|....|::||.:...:..:|.|.|.:|.:.:::......::.|.|:.:::|.
 Frog   328 -------AEFDFRTYDGEGVILYAESADSTSWFLLALRDGKIEIQFKNELWTKVTTGGKAINNGE 385

  Fly   186 WHKVQVLRNDEQTSLI--------VDGVSQQRSTKGKEFQFGKFASNSDVYVGGMPNWYSSKLAL 242
            ||.:.|   :|..::|        |..::..||.    |:.......:.||:.|:|.    |:..
 Frog   386 WHIITV---EELENIISVKIAKEAVMNINNPRSL----FKPANGILETKVYIAGLPR----KIEN 439

  Fly   243 LALPSVIFEPRFRGAIR--NLVYADQPGGSTRRQEIKQQRDIKCGDVPCDHGELPARERPLRGVR 305
            :..|   ..||..|.||  ||:                           :.|.|..:| .::|.:
 Frog   440 IIKP---INPRLDGCIRGWNLM---------------------------NQGALGVKE-VIQGKQ 473

  Fly   306 GGNTTDACERNDPCQHGGICISTDSGPICECRNLEYDGQYCEKEKAPSEATFRGTQFLSYDLGQT 370
            ..:...:.||......||:                              |.|    |::|: ..|
 Frog   474 SKHCLVSVERGSYYPGGGV------------------------------ARF----FMNYN-DST 503

  Fly   371 GAEPIVSAQDAISFYFRTRQPNGLLFYTGHG-TDYLNLALRDGGVSLTMGLANGKQEMHIKPSKV 434
            ..|...:    |:...|:....|::|...:| |..|.:|:.|.......|:.     :.|
 Frog   504 NGEWFAN----ITLNIRSSTGIGVMFSLVNGETVPLAIAIEDLASDFLQGIV-----VSI----- 554

  Fly   435 RFDDHQWHKVTVHRRIQE---------IS-SITSFCRLVTV---VDDVYTDHSHIAGKFTMLSSS 486
                   |.|||.|...:         || |:|....::|.   .|..|...:.:..:.::|..:
 Frog   555 -------HSVTVARLTTKRICTDKNLLISVSVTKSSLVLTANSYTDITYASQAELEKQLSVLDQA 612

  Fly   487 R-----VYVGGAVNPRALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQ 546
            .     .|:||......:....|...:|||:..      |:|..|:||..:.||...:.   .:.
 Frog   613 MRENPDTYLGGIPADIPVAATPVSAYYVGCMDV------TINNQLMDLDGAISKQNDIR---SHS 668

  Fly   547 CP 548
            ||
 Frog   669 CP 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058	37/162 (23%)
		EGF_CA	311..347	CDD:238011	4/35 (11%)
		Laminin_G_2	386..517	CDD:280389	30/149 (20%)
		LamG	555..716	CDD:238058
		EGF	746..777	CDD:278437
		Laminin_G_2	814..945	CDD:280389
		LamG	988..1136	CDD:238058
		EGF	1164..1195	CDD:278437
		Laminin_G_2	1233..1356	CDD:280389
pros1	NP_001119539.1	GLA	24..86	CDD:214503
		EGF_CA	121..156	CDD:238011
		FXa_inhibition	168..201	CDD:291342
		EGF_CA	203..243	CDD:284955
		vWFA	<241..281	CDD:294047	1/6 (17%)
		LamG	315..457	CDD:238058	38/173 (22%)
		LamG	484..648	CDD:238058	40/225 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910