DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-1 and Nrxn1

DIOPT Version :9

Sequence 1:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster
Sequence 2:	XP_038968743.1	Gene:	Nrxn1 / 60391	RGDID:	628659	Length:	1516	Species:	Rattus norvegicus

Alignment Length:	1479	Identity:	514/1479 - (34%)
Similarity:	774/1479 - (52%)	Gaps:	184/1479 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 VLIVSALLVSLAASFVTLSAGFQLDGSQNSFYTFRKWYTGLNGTLELEFKTEQPNGLVLYTDDGG 148
            :|.:|.||:...|.   |.:|.:..|::..:..|.||.......:..:.||....|||||.||.|
  Rat    13 LLCLSLLLLGCWAE---LGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEG 74

  Fly   149 TYDFFELKLVEGA-LRLRYNL-GGGAQIITVGRELHDGHWHKVQVLRNDEQTSLIVD-GVSQQRS 210
            ..||.||.|..|. |:|.::: ......:.....::||.||.|::.|....|:|.:| ..::...
  Rat    75 FCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDRAEAKWVE 139

  Fly   211 TKGKEFQFGKFASNSDVYVGGMPNWYSSKLALLALPSVIFEPRFRGAIRNL-VYADQPGGSTRRQ 274
            .|.|......|   |.::|||:|....:....|.|.||.....|:|.||:: |.:.|.
  Rat   140 VKSKRRDMTVF---SGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQA------- 194

  Fly   275 EIKQQRDIKCGDVPCDHGELPARERPLRGVRGGNTTDACERND--PCQHGGICISTDSGPICECR 337
                        :|.|..|:...|.|... .||:..:|.:..|  .|.:||:|...|...:|:|.
  Rat   195 ------------LPVDGSEVKLDEEPPNS-GGGSPCEAGDEGDGGVCLNGGVCSVVDDQAVCDCS 246

  Fly   338 NLEYDGQYCEKE------------------KAPSE--ATFRGTQFLSYDLGQTGAEPIVSAQDAI 382
            ...:.|:.|.:|                  |...|  |||:|:::..|||.|   .||.|:.|.|
  Rat   247 RTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQ---NPIQSSSDEI 308

  Fly   383 SFYFRTRQPNGLLFYTGHGTDYLNLALRDGGVSLTMGLANGKQEMHIKPSKVRFDDHQWHKVTVH 447
            :..|:|.|.|||:.:||...||:||||::|.|||.:.|.:|..|..::|...:|:|:.||.|.|.
  Rat   309 TLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVT 373

  Fly   448 RRIQEISSITSFCRLVTV-VDDVYTDHSHIAGKFTMLSSSR-VYVGGAVNPRALLGARVHTNFVG 510
            |.:::.|.|..  .:||: ||.:.|...:....:|||.|.. .||||:.:...|.|:.|..||:|
  Rat   374 RNLRQHSGIGH--AMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMG 436

  Fly   511 CLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQCPSGDPQDPVTFTTRESHLVLPPWETGKQ 575
            ||::|.:..:.:.|.|..|||.|...:::.|.:.::|.:....||:||.|.||.:.||.|...|.
  Rat   437 CLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKT 501

  Fly   576 SSISFKFRTKEPNGIIVLATGSKQPR----AKNPVLI-----AIELLNGHIYIHLDLGSGASKVR 631
            .||||.|||.||||:|:.:.|  :||    ||:|.:|     |||:|:||:|:.||:|||..|::
  Rat   502 GSISFDFRTTEPNGLILFSHG--KPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIK 564

  Fly   632 ASRRRVDDGDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTILELDGHMYLGGVGPAYNSVSWPA 696
            |.:::|:||:|:.:..:|:||...:||:.:...:..||:..||:||..:||||:......:.:|.
  Rat   565 ALQKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPT 629

  Fly   697 AIWTATLRQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSCHVQ-ANVCNGNPCLNGGTCLEG 760
            .:|||.|..|:|||:|||.:.|::.||...|.:|.:|.|||||..: |..|..|||.|.|.|.:|
  Rat   630 EVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEIQSTAGVKPSCSRETAKPCLSNPCKNNGMCRDG 694

  Fly   761 WNRPICDCSATLYGGPTCGRELATLAFNGSQHMTIWLGNGQGTKTQTEELVIRFKTSRPAGLLLL 825
            |||.:||||.|.|.|.:|.||...|:::||..|.|.|  .....|:.|::.:||::.|..|:|:.
  Rat   695 WNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQL--PVVMHTEAEDVSLRFRSQRAYGILMA 757

  Fly   826 TSAESNSPDRLEIALVAGRVRASVRL---------SDREKNLLAGQSVLNDNNWHTIRFSRRASN 881
            |::. :|.|.|.:.|.||||:.:|.|         |...:.|.||.: ||||.|||:|..||..:
  Rat   758 TTSR-DSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYN-LNDNEWHTVRVVRRGKS 820

  Fly   882 LRLQVDGAPPVRGMLSETILGRHSTMEIRSVHLGGLFHAEEEIQMTSTMPNFVGQMQGLVFNGQR 946
            |:|.||....:.|.::    |.|:.:|..::..|.:   .|...::|...||:|.:|.|.|||..
  Rat   821 LKLTVDDQQAMTGQMA----GDHTRLEFHNIETGII---TERRYLSSVPSNFIGHLQSLTFNGMA 878

  Fly   947 YLDIVKSLGPELSALPSATFKLTARF-----VNSPAGQPYHAATFRSKHSYVGLAMLKAYNSISI 1006
            |:|:.|:...:..       :|.|||     :..|       .||::|.|||.||.|:||.|:.:
  Rat   879 YIDLCKNGDIDYC-------ELNARFGFRNIIADP-------VTFKTKSSYVALATLQAYTSMHL 929

  Fly  1007 DFRFKTVEPNGLLVFNGGRRNDFVAVELVNGHIHYTFDLGDGPVTMRDKSRIHMNDNRWHQVSIR 1071
            .|:|||...:||:::|.|..|||:.||||.|::||.||||:|...::..|...:|||:||.|.|.
  Rat   930 FFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMIS 994

  Fly  1072 RPGPKTHTLTVDDSFEIISLTGNNMHLELAGILYIGGVFKDMYSKLPASISSRSGFEGCLASLDL 1136
            |.....||:.:|... ...:|....:|:|...||||||.|:.|..||..:.::.||:|||||:||
  Rat   995 RDTSNLHTVKIDTKI-TTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDL 1058

  Fly  1137 GDASPSLTSDAVVPSSLVVSGCE---------GP-TKCSQNACANRGNCVQQWNAYACECDMTSY 1191
            ....|.|.|||:..:..:..|||         || |.|.:::|:|:|.|:|||:.::|:|.|||:
  Rat  1059 NGRLPDLISDALFCNGQIERGCEVALMKADLQGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSF 1123

  Fly  1192 TGPTCYDESIAYEFGNNKGMVQYTFPENAQADTEEDNIALGFITTRPDAVLLRVESAT-TQDYME 1255
            :||.|.|....|.|....|.:.|.:|.|.:..|..|.:|:||.|.:.:|||:||:|:: ..||:|
  Rat  1124 SGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLE 1188

  Fly  1256 LEIVEGNIFMVYNIGSVDLPLGEIGTKVNDNAYHVVRFQRKGGNATLQLDDYNV----------- 1309
            |.|.:|.|.:.:|:|:.|:.:.|....:||..||||||.|.|||||||:|.:.|
  Rat  1189 LHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDN 1253

  Fly  1310 -------------------QALTPQSHHSTVFNTMSNVQVGGKFSRNGRNRIERPFAGVIAGLSV 1355
                               :.|..:....|:||:.:.:.:|||  ..|     :||.|.::||..
  Rat  1254 ERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGK--EQG-----QPFQGQLSGLYY 1311

  Fly  1356 NKLRILDLAVERDPHITIRGDVQLV-------------TGVLDRNDLQRMQQTLNSTRQTPASGY 1407
            |.|::|::|.|.|.:|.|.|:|:||             |.:........|:.|......|...|.
  Rat  1312 NGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGK 1376

  Fly  1408 P-------GALDDLIFSGAGSGCRGDDEDECTPPFESGSGDDLITPVYV 1449
            |       ...||::.  |.:.|..||||  ..|.|..|| .|..|..|
  Rat  1377 PPTKEPISQTTDDILV--ASAECPSDDED--IDPCEPSSG-GLANPTRV 1420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058	46/156 (29%)
		EGF_CA	311..347	CDD:238011	10/37 (27%)
		Laminin_G_2	386..517	CDD:280389	53/132 (40%)
		LamG	555..716	CDD:238058	74/169 (44%)
		EGF	746..777	CDD:278437	18/30 (60%)
		Laminin_G_2	814..945	CDD:280389	47/139 (34%)
		LamG	988..1136	CDD:238058	65/147 (44%)
		EGF	1164..1195	CDD:278437	14/30 (47%)
		Laminin_G_2	1233..1356	CDD:280389	50/153 (33%)
Nrxn1	XP_038968743.1	LamG	30..190	CDD:238058	48/162 (30%)
		LamG	307..446	CDD:214598	54/140 (39%)
		LamG	503..652	CDD:214598	64/150 (43%)
		EGF_CA	680..713	CDD:238011	18/32 (56%)
		LamG	741..877	CDD:214598	48/144 (33%)
		Laminin_G_2	933..1061	CDD:396680	56/128 (44%)
		LamG	1134..>1253	CDD:238058	47/118 (40%)
		Syndecan	1441..>1476	CDD:395821
		4.1m	1461..1479	CDD:128590
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I4871
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	831	1.000	Inparanoid score	I428
OMA	1	1.010	-	-		QHG46386
OrthoDB	1	1.010	-	-		D24127at33208
OrthoFinder	1	1.000	-	-		FOG0001168
OrthoInspector	1	1.000	-	-		otm46164
orthoMCL	1	0.900	-	-		OOG6_103392
Panther	1	1.100	-	-	O	PTHR15036
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X794
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980