Protein Alignment Nrx-1 and Gas6

DIOPT Version :9

• Sequence 1: NP_001262840.1
• Gene: Nrx-1 / 42646
• FlyBaseID: FBgn0038975
• Length: 1847
• Species: Drosophila melanogaster
• Sequence 2: NP_476441.2
• Gene: Gas6 / 58935
• RGDID: 61913
• Length: 674
• Species: Rattus norvegicus
• Alignment Length: 564
• Identity: 114/564 - (20%)
• Similarity: 189/564 - (33%)
• Gaps: 164/564 - (29%)

  Fly   265 DQPG--------GSTRRQEIKQQRDI-------KCGDVPCDHGELPARERPL--RGVRGGNTTDA 312
            ::||        |.:.:.:.|..:||       .|||..|.:  ||.....|  :|....:....
  Rat   170 NKPGSFQCACHSGFSLQSDNKSCQDIDECTDSDTCGDARCKN--LPGSYSCLCDKGYTYSSKEKT 232

  Fly   313 CERNDPCQHG---GICISTDSGPICECR-----NLEYDGQYCEK-------EKAPS-EATFRGTQ 361
            |:..|.||..   ..|:::.....|.|.     .|..|...||.       ..|.| ::.:.|..
  Rat   233 CQDVDECQQDRCEQTCVNSPGSYTCHCNGRGGLKLSPDMDTCEDILPCVPFSMAKSVKSLYLGRM 297

  Fly   362 FLSYDLGQTGAEPIVSAQDAISFYFRTRQPNGLLFYTGHGTD--YLNLALRDGGVSLTMGLANGK 424
            |....:.:...:.:...:....|.|||..|.|:||:.|..:|  ::.|..|.|.:.|.:.. ||.
  Rat   298 FSGTPVIRLRFKRLQPTRLLAEFDFRTFDPEGVLFFAGGRSDSTWIVLGFRAGRLELQLRY-NGV 361

  Fly   425 QEMHIKPSKVRFDDHQWHKVTVHRRIQEISSITSFCRLVTVVDDVYTDHSHIAGKFTM---LSSS 486
            .  .|..|....:...|..::|....:.:        ::.|..|.....:...|.|.:   |...
  Rat   362 G--RITSSGPTINHGMWQTISVEELDRNL--------VIKVNKDAVMKIAVAGGLFQLERGLYHL 416

  Fly   487 RVYVGGAVNPRALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKLIQ--VAGNLEYQCPS 549
            .:.|||.....:.|...::....||:|...:      ||..|.|      ||  |..|.:.||
  Rat   417 NLTVGGIPFKESDLVQPINPRLDGCMRSWNW------LNGEDSA------IQETVKANTKMQC-- 467

  Fly   550 GDPQDPVTFTTRESHLVLP----------------------PWETGKQSSISFKFRTKEPNGIIV 592
                    |:..|.....|                      .||.    .:..:.|.....|:::
  Rat   468 --------FSVTERGSFFPGNGFAFYSLNYTRTSLDVGTETTWEV----EVVARIRPATDTGVLM 520

  Fly   593 LATGSKQPRAKNPVLIAIELLNGHIYIHLDLGSGASKVRAS--------------RRRVDDGDWH 643
            ...|.     |:.||:::.|::.|         ...|::..              ..:|.|...|
  Rat   521 ALVGD-----KDVVLLSVALVDYH---------STKKLKKQLVVLAVENVALALMEIKVCDSQEH 571

  Fly   644 DLILRRNGRDAKVSVDGVWND--------------FRTPGDGTILELDGHMYLGGVGPAYNSVSW 694
            .:.:.....:|.:.|||....              .:|...|::|     .::||: |.....|.
  Rat   572 TVTVSLRDGEATLEVDGTKGQSEVSTAQLQERLDLLKTRLQGSVL-----TFVGGL-PDVQVTST 630

  Fly   695 PAAIWTATLRQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPS 738
            |.   ||..|    ||: .|.::||.:|:       |:||.|.|
  Rat   631 PV---TAFYR----GCM-TLEVNGKTLDL-------DTASYKHS 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058
		EGF_CA	311..347	CDD:238011	9/43 (21%)
		Laminin_G_2	386..517	CDD:280389	31/135 (23%)
		LamG	555..716	CDD:238058	35/210 (17%)
		EGF	746..777	CDD:278437
		Laminin_G_2	814..945	CDD:280389
		LamG	988..1136	CDD:238058
		EGF	1164..1195	CDD:278437
		Laminin_G_2	1233..1356	CDD:280389
Gas6	NP_476441.2	GLA	26..90	CDD:214503
		EGF_CA	115..150	CDD:238011
		FXa_inhibition	157..192	CDD:291342	4/21 (19%)
		EGF_CA	194..225	CDD:214542	10/32 (31%)
		cEGF	215..238	CDD:289433	3/22 (14%)
		FXa_inhibition	244..274	CDD:291342	5/29 (17%)
		LamG	295..447	CDD:238058	34/162 (21%)
		Laminin_G_2	510..647	CDD:280389	30/164 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910