DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nrx-1 and lama1

DIOPT Version :9

Sequence 1:NP_001262840.1 Gene:Nrx-1 / 42646 FlyBaseID:FBgn0038975 Length:1847 Species:Drosophila melanogaster
Sequence 2:NP_001030158.1 Gene:lama1 / 569971 ZFINID:ZDB-GENE-060118-1 Length:3075 Species:Danio rerio


Alignment Length:1191 Identity:265/1191 - (22%)
Similarity:463/1191 - (38%) Gaps:229/1191 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 TARTRPSMDMDQQRNRNQAELRLLPAQRTSTSAFESPDLRFNKARRRRRSEQVPPVVVEYRRSYR 83
            |.||...: .|.|...|.|..||..|           |::.::...|.:..|.....:....|..
Zfish  2054 TQRTNQLL-RDSQDTANAAGSRLSEA-----------DVKADRLLERLKPLQTLGETLSRNLSDI 2106

  Fly    84 VLIVSALLVSLAASFVTLSAGFQLDGSQNSFYTFRKWYTGLN-GTLELEFKTEQPNGLVLYTDDG 147
            ..::|......|:..|.:||      .:|....:|...|..| .||.|..||.:|:.|:.|....
Zfish  2107 RELISQARKQAASIKVAVSA------DRNCVRAYRPEVTSSNFNTLTLTMKTSEPDNLLFYMGSS 2165

  Fly   148 GTYDFFELKLVEGALRLRYNLGGGAQIITV-GRELHDGHWHKVQVLRNDEQTSLIVDGVSQQRST 211
            .:.||..|::.:|.:...::.|.|...:.. ..::::..||::...|.....:|.|.....:...
Zfish  2166 SSEDFMALEMHDGKVSFLWDAGSGHNRLEYPDVQINNDKWHRINATRFGRHATLTVQQTDSEPLP 2230

  Fly   212 KGKEFQFGKFASNSD------VYVGGMPNWYSSKLALLALPSVIFEPRFRGAIRNLVYADQPGGS 270
            ..|....|. |:..|      |||||:                                   || 
Zfish  2231 AVKSSAAGS-ATVMDVNKHTWVYVGGL-----------------------------------GG- 2258

  Fly   271 TRRQEIKQQRDIKCGDVPCDHGELPARERPLRGVRGGNTTDACERNDPCQHGGICISTDSGPICE 335
                ::|:...:|........||....|..:      ...:..||...|  || |..:   |..|
Zfish  2259 ----QVKKSPAVKITHFRGCMGEALLNENNI------GLWNYAERQGEC--GG-CFRS---PRTE 2307

  Fly   336 CRNLEYDGQ-YCEKEKAPSEATFRGTQFLSYDLGQTGAEPIVSAQDAISFYFRTRQPNGLLFY-T 398
            ..:..:||. :...||:                       :.|...::..:|:|..|||||.| .
Zfish  2308 DTSFHFDGSGFSVVEKS-----------------------LRSMSTSVVMFFKTLSPNGLLLYLA 2349

  Fly   399 GHGT-DYLNLALRDGGVSLTMGLANGKQEMHIKPSKVRFDDHQWHKVTVHR-----RIQEISSIT 457
            .:|| |:|::.|.:|.|.||..|.:|...|   .|...::...|:::.:.|     .:..:::..
Zfish  2350 SNGTRDFLSIELVEGKVHLTFELGSGALTM---TSSRTYNTGSWYRIALQRNKRKGHLSVMAASN 2411

  Fly   458 SFCRLVTVVDDVYTDHSHIAGKFTMLSSS---RVYVGGAVNPRALLGARVHTNFVGCLRKVEFSA 519
            ...|.|.        .:...|:.:.|:.|   .:|:||....|.:....|..:||||::.||   
Zfish  2412 PSEREVL--------EAEAPGQASDLNRSDLDPIYIGGLPASRPIRRQVVARSFVGCMKNVE--- 2465

  Fly   520 DTLNLNLIDLAKSGSKLIQVAGNLEYQCPSGDPQDPVTFTT--RESHLVLPPWETGKQSSISFKF 582
                     :|::...|::.|    |....|....|:...:  ....|.:|.......:.|...|
Zfish  2466 ---------IARTNFDLLREA----YGVKKGCVLKPIRSVSVFGGGFLEMPAVLLSSHTEIMSTF 2517

  Fly   583 RTKEPNGIIVLATGSKQPRAKNPVLIAIELLNGHIYIHLDLGSGASKVRAS-RRRVDDGDWHDLI 646
            .::..:|:| ||..|:..|.....|:.:.|::|.:.:.:.:..||:..:|. |....||..|.||
Zfish  2518 SSRRDSGVI-LAGFSRSSRHTQQPLLLLLLVSGGLELRVSVSDGAAVQKAELRGSFSDGHEHSLI 2581

  Fly   647 LRRNGRDAKVSVD-GVWNDFRTPGDG-TILELDGHMYLGGVGPAYNSVSWPAAIWTATLRQGFVG 709
            |:||.|...|.|| |:....:.|... ..|.|: .:|:|||.||...        |.||...|.|
Zfish  2582 LQRNKRTITVVVDEGIQASLKLPASAEKSLTLE-RLYIGGVPPAEGD--------THTLTPAFYG 2637

  Fly   710 CLRDLVLSGKAIDIAAFARVQ----DSASVKPSCHVQANVCNGNPCLNGGTCLEGWNRPICDCSA 770
            |:|:..:.|..:|::|..|.:    ||..::|.........:..|..:..|      ||:...:|
Zfish  2638 CIRNTAVDGMLLDLSAALRYEQVDMDSCLLEPRPRRVLLPDDPEPTSDPDT------RPLTPAAA 2696

  Fly   771 TL------YGGPTCGRELATL----AFNGSQHMTIWLGNGQGTKTQTEELVIRFKTSRPAGLLLL 825
            .|      .|.........|:    .|..|:|..:.:|....|...:..:.:..:|...:|:|..
Zfish  2697 ELSALTPNSGSCASADHTQTIPESHQFGLSRHSHLIMGFKNRTVRTSFAVKLSVRTFAHSGVLFY 2761

  Fly   826 TSAESNSPDRLEIALVAGRVRASVRLSDREKNLLAGQSVLNDNNWHTIRFSRRASNLRLQVDGAP 890
             .|.:|..|...:.|.|||:..|..|.....:... ::.::|..|||::.......:.:.||   
Zfish  2762 -MANTNQQDYAVLQLQAGRLHLSCDLGKGAASATL-KNTISDGRWHTVKAEFSKKTVVVSVD--- 2821

  Fly   891 PVRGMLSETILGRHSTMEIR-SVHLGGLFHAEEEIQMTSTMPNFVGQMQGLVFNGQRYLDIVKSL 954
               |:.|:.|..:..|:::. .:::|||.......::.:...:....:|.|.|||     :..:|
Zfish  2822 ---GIESDHISTKGHTLDVEGKLYVGGLPPTYTAKRIGNVTHSVAACVQDLTFNG-----VPMNL 2878

  Fly   955 GPELSALPSATFKLTARFVNSPAGQPYHAATFRSKHSYVGLAMLKAYN---SISIDFRFKTVEPN 1016
            ...||:..:...     |.|:..|      ||.:...|... |.:.||   .:::...|::..|:
Zfish  2879 NNPLSSHATGFC-----FSNAQDG------TFFNGSGYAAF-MKEGYNVGSDVTVSLEFRSTAPD 2931

  Fly  1017 GLLVFNGGRRNDFVAVELVNGHIHYTFDLGDGPVTMRDKSRIHMNDNRWHQVSIRRPGPKTH--T 1079
            |:|:.....:.|.:.:||:||.:.:..:.|.|.:::..:|.:.|.|.||..:..::   :.|  :
Zfish  2932 GVLLGISSTKVDAIGLELLNGQVVFNVNNGAGRISVSSRSSVSMCDGRWRTLVAKK---QKHSLS 2993

  Fly  1080 LTVDDSFEIISLTGNNMH-----LELAGILYIGGVFKDMYSKLPASISSRSGFEGCLASL----- 1134
            ||||.    :::...|.|     .|....:|:||...|:...   .:|.|..|.||:.:|     
Zfish  2994 LTVDG----VTVNAENPHSSSTSAETKNPIYVGGHPADVKQN---CLSVRQSFRGCMRNLRVFKG 3051

  Fly  1135 ---DLGDASPSLTSDAVVPSS 1152
               |:.|.|.:.|...|.|.|
Zfish  3052 HVTDVLDFSSAFTLLHVSPHS 3072

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nrx-1NP_001262840.1 LamG 110..263 CDD:238058 32/160 (20%)
EGF_CA 311..347 CDD:238011 10/36 (28%)
Laminin_G_2 386..517 CDD:280389 38/140 (27%)
LamG 555..716 CDD:238058 47/165 (28%)
EGF 746..777 CDD:278437 7/36 (19%)
Laminin_G_2 814..945 CDD:280389 29/131 (22%)
LamG 988..1136 CDD:238058 38/165 (23%)
EGF 1164..1195 CDD:278437
Laminin_G_2 1233..1356 CDD:280389
lama1NP_001030158.1 LamNT 25..275 CDD:214532
EGF_Lam 277..324 CDD:238012
EGF_Lam <364..390 CDD:238012
Laminin_EGF 404..463 CDD:278482
Laminin_EGF 461..506 CDD:278482
Laminin_B 571..699 CDD:278481
EGF_Lam 744..792 CDD:238012
Laminin_EGF 809..849 CDD:278482
EGF_Lam 851..903 CDD:238012
Laminin_EGF 905..951 CDD:278482
Laminin_EGF 954..1001 CDD:278482
EGF_Lam 1000..1045 CDD:238012
Laminin_EGF 1047..1095 CDD:278482
Laminin_EGF 1093..1149 CDD:278482
Laminin_B 1221..1346 CDD:278481
EGF_Lam <1365..1385 CDD:238012
Laminin_EGF 1407..1453 CDD:278482
Laminin_EGF 1456..1509 CDD:278482
Laminin_EGF 1512..>1549 CDD:278482
Laminin_I 1580..1842 CDD:283627
Baculo_PEP_C 1581..1711 CDD:282382
Laminin_II 2015..2148 CDD:283628 25/111 (23%)
LamG 2133..2281 CDD:238058 37/188 (20%)
LamG 2310..2466 CDD:238058 44/201 (22%)
LamG 2491..2641 CDD:238058 45/159 (28%)
Laminin_G_1 2750..2877 CDD:278483 30/139 (22%)
LamG 2897..3048 CDD:238058 41/167 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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