DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-1 and crb2b

DIOPT Version :9

Sequence 1:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster
Sequence 2:	NP_001038627.1	Gene:	crb2b / 568520	ZFINID:	ZDB-GENE-060610-1	Length:	1458	Species:	Danio rerio

Alignment Length:	1414	Identity:	255/1414 - (18%)
Similarity:	429/1414 - (30%)	Gaps:	547/1414 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 KCGDVPCDHGE-------------LPARERPLRGVRGGNTTDACERNDPCQHGGICISTDSGPIC 334
            :|...||.:|.             :|..|    |:......|.|| :.||:|||:|:...:|..|
Zfish   264 ECEASPCQNGAVCHDHVGLYTCECVPGYE----GINCELDIDECE-SSPCRHGGVCLDMVNGYEC 323

  Fly   335 ECRNLEYDGQYCEKEKAPSEATFRGTQFLSYDLGQTGAEPI---VSAQDAISFYFRTRQPNGLLF 396
            :|....:.|.:|:                 .|:.:..::|.   .:..:.::.|       ..:.
Zfish   324 DCSGTGFMGFFCD-----------------IDIPECSSDPCQHGATCLEGVNHY-------TCIC 364

  Fly   397 YTGHGTDYLNLALRDGGVSLTMGLANGKQEMHIKPSKVRFDDHQWHKVTVHRRIQEISSITSF-- 459
            :||:           .||:..:.:    .|...:|.:......|....:::|.:.|:.:..||
Zfish   365 WTGY-----------EGVNCELDV----DECVSQPCENEGQCFQRSDSSLYRVLPELDTDFSFQS 414

  Fly   460 -----CRLVTVVDDVYTDHSHIAGKFTMLS-----SSRVYVGGA----VN------PRALLGARV 504
                 |:.|          |...|:...::     |:....||:    ||      |....||..
Zfish   415 AAGYLCQCV----------SGFTGENCSVNVNECESAPCENGGSCEDLVNAFQCSCPPGFAGAVC 469

  Fly   505 HTNFVGC----LRKVEFSADTLNLNLIDL--AKSG-------SKLIQVAG--------------N 542
            .|....|    .:......|::|..:...  |:.|       ...:|:.|              :
Zfish   470 ETELDECESDPCQNRGRCEDSINAYICHCPPAEPGHLPWGGPDCSVQLTGCVDQPCQNNATCIPS 534

  Fly   543 LEYQ-------CPSG----DPQDPVTFT-TRESHLVLPPWETGKQS---------SISFKFRTKE 586
            :::|       ||||    ..|...||: ||..:|::.......:|         |:..:|||..
Zfish   535 IQHQQHQHTCRCPSGFHGTHCQTSTTFSITRGGYLLIDLHHKNNRSRRYLDSHVPSVQLRFRTTL 599

  Fly   587 PNGIIVLATGSKQPRAKNPVLIAIELLNGHIYIHLDLGSGASKVRASRRRVDDGDWHDLILRRNG 651
            .:|:|....|...       ...:||:.|.:|.                |...||. .|.::.||
Zfish   600 QDGVIFFRGGQNH-------FFVLELIAGELYC----------------RAQSGDL-KLFVKLNG 640

  Fly   652 -------RDAKVSVDGVWNDFRTPGDGTILELDGH-------------MYLGGVGPAYNSVSWPA 696
                   |...||||   .......:|.:.|..||             :|:|||         |.
Zfish   641 DFGDGFWRGVSVSVD---EGLTVLSEGEMGEDGGHNQLLSFQPQGLETLYVGGV---------PQ 693

  Fly   697 AIWTATL-RQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSCHVQANVCNGNPCLNGGTCLEG 760
            .....|| |.||||||.|||:..:.:...:...:|:   |:..|. :...|..|||.:.|.|::.
Zfish   694 EWMNLTLSRTGFVGCLEDLVVDSEPVLPQSLVPLQE---VQMGCE-RTEWCRVNPCSDHGRCVDL 754

  Fly   761 WNRPICDCSATLYGGPTCGRELATLAFNGSQHMTIWLGNGQGTKTQTEELVIRFKTSRPAGLLLL 825
            |:...|.|....| |..|..|..:..|:
Zfish   755 WSNYTCVCHRPYY-GEHCSEEHTSWTFS------------------------------------- 781

  Fly   826 TSAESNSPDRLEIALVAGRVRASVRLSDREKNLLAGQSVLNDNNWHTIRFSRRASNLRLQVDGAP 890
                                        .|:|
Zfish   782 ----------------------------HERN--------------------------------- 785

  Fly   891 PVRGMLSETILGRHS-----TMEIRSVHLGGLFHAEEEIQMTSTMPNFVGQMQGLVFNGQRYLDI 950
              |...:..|:..||     ::.:||.||.||                |.|:|
Zfish   786 --RSFAAFPIMQNHSRDVTVSLWLRSRHLNGL----------------VLQLQ------------ 820

  Fly   951 VKSLGPELSALPSATFKLTARFVNSPAGQPYHAATFRSKHSYVGLAMLKAYNSISIDFRFKTVEP 1015
                                     ...|||.....::...|:.:     |:||.
Zfish   821 -------------------------HDNQPYLTLFLKNGSLYISI-----YSSIR---------- 845

  Fly  1016 NGLLVFNGGRRNDFVAVELVNGH-IHYTFDLGDGPVTMRDKSRIHMNDNRWHQVSIRRPGPKTHT 1079
                     |.:||    |.||. :..:.....|.:......||.|
Zfish   846 ---------RASDF----LTNGEKLFMSIKTEPGVILFNQTQRIPM------------------- 878

  Fly  1080 LTVDDSFEIISLTGNNMHLELAGILYIGGVFKDMYSKLPASISSR---SGFEGCLASLDLGDASP 1141
              :...||:          ::..::|:||        ||...:|.   ..|:|||..:.:.|...
Zfish   879 --IYSGFEV----------QVGDVVYLGG--------LPEGENSALWGGYFKGCLQDVRIDDTQL 923

  Fly  1142 SLTSDAV---------VP--SSLVVSGCEGPTKCSQNACANRGNCVQQWNAYACECDMTSYTGPT 1195
            .:.|.::         :|  ||.|:.||.|...|....|.|.|.|...||.:.|.|.: :::|.|
Zfish   924 FMYSGSISQKPQHANYLPRNSSNVLEGCVGDQTCKMKPCLNGGKCQVIWNDFMCLCPL-NFSGKT 987

  Fly  1196 -----------------CYDESIAYE------FGNNKGMVQYTFPENAQADTEEDNIALGFITTR 1237
                             |.|....||      |.||    ...|..|.........|::...|..
Zfish   988 CETRVWCVSDPCDPRTRCVDLPDGYECLANATFENN----ALKFSANGSFFEPVMRISMDLRTRE 1048

  Fly  1238 PDAVLLRVESATTQDYMELEIVEGNIFMVY-NIGSVDLPLGEIGTKVNDNAYHVVRFQRKGGNAT 1301
            .:..:||  |:...::..:.::..:|.:.: :..|:::........|:|..:|.|.........:
Zfish  1049 ENGTILR--SSNGIEFFCMGLLNSSIIVKFRDSNSLEVHAFISDVTVSDGEWHKVELYASSSRIS 1111

  Fly  1302 -----LQLDDYNVQ-ALTPQS-----HHSTVF------NTMSNVQVGGKFSRNGRNRIERPFAGV 1349
                 :.:|..... :|:|..     :.|||.      ..:..|::||         :...|.|.
Zfish  1112 AFRWHMSIDGNPAGFSLSPAGNVDFFNSSTVMLAENYTGCLGEVRIGG---------VHLSFFGP 1167

  Fly  1350 IAGLSVNKLRILDLAVERDPHITIRGDVQLVTGVLDRN----DL--------------QRMQQTL 1396
            :...:..|.:.:.:....:||:...|....::.....|    ||              :|.|:.:
Zfish  1168 LNEEAPQKTQFIRIGGMLEPHLGCIGSPLCLSEPCLNNGTCTDLFNLAVCKCAPGWTGERCQENI 1232

  Fly  1397 NSTRQTPASGYPGALDDLIFSGAGSGCRGDDEDECTPPFESGSGDDLITPVYVPPTKQTTTSQQG 1461
            :...:.|.  ..|:..||:         ||.|..|...|...:.|     |.|...|.......|
Zfish  1233 DECGEQPC--VQGSCQDLL---------GDYECRCPVGFGGKNCD-----VEVDQCKDHQCENGG 1281

  Fly  1462 NSLSTGGSSSGGVITNGT---------ERACD-DEDCVHG----SGDYG 1496
            :.::|....:...:...|         .|.|| |..|.:|    .|.:|
Zfish  1282 SCVATVSGYTCVCLPGHTGPYCRWRFPPRECDVDLQCENGGVCSEGSWG 1330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058
		EGF_CA	311..347	CDD:238011	13/35 (37%)
		Laminin_G_2	386..517	CDD:280389	25/156 (16%)
		LamG	555..716	CDD:238058	48/191 (25%)
		EGF	746..777	CDD:278437	11/30 (37%)
		Laminin_G_2	814..945	CDD:280389	15/135 (11%)
		LamG	988..1136	CDD:238058	26/151 (17%)
		EGF	1164..1195	CDD:278437	10/30 (33%)
		Laminin_G_2	1233..1356	CDD:280389	21/140 (15%)
crb2b	NP_001038627.1	EGF_CA	108..144	CDD:238011
		EGF_CA	152..183	CDD:238011
		EGF_CA	185..221	CDD:238011
		EGF_CA	223..259	CDD:238011
		EGF_CA	261..297	CDD:238011	7/36 (19%)
		EGF_CA	299..335	CDD:238011	13/36 (36%)
		EGF_CA	338..374	CDD:238011	7/53 (13%)
		EGF_CA	434..470	CDD:238011	8/35 (23%)
		EGF_CA	474..>500	CDD:214542	3/25 (12%)
		LamG	590..715	CDD:238058	43/160 (27%)
		EGF_CA	<743..771	CDD:238011	10/28 (36%)
		LamG	784..919	CDD:238058	43/289 (15%)
		EGF	957..987	CDD:278437	10/30 (33%)
		Laminin_G_2	1044..1160	CDD:280389	19/126 (15%)
		EGF	1197..1227	CDD:278437	3/29 (10%)
		EGF_CA	1231..1265	CDD:238011	9/44 (20%)
		EGF_CA	1269..1303	CDD:238011	5/33 (15%)
		EGF_CA	1347..1383	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910