DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrx-1 and lama4

DIOPT Version :9

Sequence 1:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster
Sequence 2:	NP_001034154.1	Gene:	lama4 / 566796	ZFINID:	ZDB-GENE-040724-213	Length:	1871	Species:	Danio rerio

Alignment Length:	906	Identity:	209/906 - (23%)
Similarity:	323/906 - (35%)	Gaps:	292/906 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 RKWYTGLNGTLELEFKTEQPNG-LVLYTDDGGTYDFFELKLVEGALRLRYNLG--GGAQIITVG- 178
            |:...|:....::|.:|...|| |.|..::   .:||.|:|..|.|||.|:.|  .|..||...
Zfish  1120 RRGKIGVVTRFDIEVRTVANNGILFLMVNE---TNFFVLELKNGFLRLMYDFGFANGPVIIETNL 1181

  Fly   179 --RELHDGHWHKVQVL-RNDEQTSLIVD--GVSQQRSTKGKEFQFGKFASNSDVYVGGMPNWYSS 238
              .:::|..:|:|.|: .:.::..|:||  .|....|.| |...|      ||:|:||.|    |
Zfish  1182 AKLQINDARYHEVSVIYHHSKKIILLVDRSHVKSFESEK-KPLPF------SDIYIGGAP----S 1235

  Fly   239 KLALLALPSVIFEPRFRGAIRNLVYADQPGGSTRRQEIKQQRDIKCGDVPCDHGELPARERPLRG 303
            :: |.:.|.:......:|.::...:              |:.|....:
Zfish  1236 RI-LQSRPELTSLIGLKGCVKGFQF--------------QKEDFNLLE----------------- 1268

  Fly   304 VRGGNTTDACERNDPCQHGGICISTDSGPICECRNLEYDGQYCEKEKAPS-EATFRGTQFLSYDL 367
                            :.|.|.||  ||              |.:|...| :|.|.|..:||
Zfish  1269 ----------------EQGTIGIS--SG--------------CPEESFMSHKAYFTGNGYLS--- 1298

  Fly   368 GQTGAEPIVSAQDAISFYFRTRQPNGLLFYTGHGTDYLNLALRDGGVSLTMGLANGKQEMHIKPS 432
            ......|..|.:..:|  |:|.||:|||||...|:|..:|:|.:|.|.|.   |.|.:   :|..
Zfish  1299 SSDKISPFQSFEGGLS--FKTLQPSGLLFYHRDGSDEFSLSLENGAVVLQ---AKGTR---VKSQ 1355

  Fly   433 KVRFDDHQWHKVTVHRRIQEISSITSFCRLVTVVDDVYTDHSHIAGKFTMLSSS-----RVYVGG 492
            |..:.|.:.|.:        ::|:|: .:...|:||   .......|.:..|.|     ..|.||
Zfish  1356 KKHYSDGRSHFL--------VASVTN-QKYEIVIDD---KDKQDKKKPSSTSQSDNTPKAFYYGG 1408

  Fly   493 AVNPRALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQCPSGDPQDPVT 557
            :.:...|       |..||:.....|....::...|..:...   .|..:|: .||...|...:.
Zfish  1409 STSSSIL-------NLTGCISYAYISRQDRDIEPEDFQRYSE---NVQASLQ-DCPIERPPSALL 1462

  Fly   558 FTTRESH-------------------------LVLPPWE-------------------------- 571
            ..:|:|.                         |.:|..|
Zfish  1463 KDSRDSSRRSAGHSRKVGRDESGLPHGLKSNPLNIPEKEEASCYLSSRPRATPHANHYGGSAHSR 1527

  Fly   572 ---TGKQSSI------SFKFRTKEPNGII-VLATGSKQPRAKNPVLIAIELLNGHIYIHLDLGSG 626
               ||..|:|      |...:|:...|:| .||..|.:.        ::.|...|..:.....||
Zfish  1528 HEYTGIASAIKHESHFSLSLKTRSAFGLIFYLADASGEN--------SMALFLTHARLVFTFSSG 1584

  Fly   627 ASKVR-ASRRRVDDGDWHDLILRRNGRDAKVSVDG--VWNDFRTPGDGTILELDGHMYLGGVGP- 687
            .|:|| .|:.:.:||.|||:|..|.|...::.:||  |..| |.||..|.|.:...:|:|||.|
Zfish  1585 QSQVRIRSKEKYNDGQWHDIIFIRAGNMGRMLIDGLTVLED-RAPGRNTSLLVQDPLYVGGVPPH 1648

  Fly   688 -AYNSVSWPAAIWTATLRQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSCHVQANVCNGNPC 751
             |..::.       .|....|.||:|.|.|:|:::..|:     .|..|.|
Zfish  1649 QAMKNIQ-------RTSVSSFTGCVRSLQLNGRSLTSAS-----HSFGVTP-------------- 1687

  Fly   752 LNGGTCLEGWNRPICDCSATLYGGPTCGRELATLAFNGSQHMTIWLGNGQGTKTQTEELVIRFKT 816
                 |.||.:.|          |.....|...:..:.|.|.      |...|...|
Zfish  1688 -----CYEGPSEP----------GTYFAEEGGYVLLDDSFHF------GSSFKMAME-------- 1723

  Fly   817 SRP---AGLLLLTSAESNSPDRLEIALVAGRVRASVR--LSDREKNLLAGQSVLNDNNWHTIRFS 876
            .||   :|:||....|..  :.|.:.:...:|...|.  :::...::...|.:. |.|||.|...
Zfish  1724 VRPRVASGVLLHVFMEQK--EYLTVYIYQSQVVVVVNNGIAEFSTHVSPTQEIC-DGNWHKITVI 1785

  Fly   877 RRASNLRLQVD------------------------GAPPVRGMLSETILGRHS-TMEIRSV 912
            |..|.|:|.||                        |||.  .|||.::|.|.. |..:|||
Zfish  1786 RDGSVLQLDVDSEVNHVVGSVSDAAQSSSSPVFIGGAPD--SMLSHSLLSRRGFTGCMRSV 1844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058	43/153 (28%)
		EGF_CA	311..347	CDD:238011	6/35 (17%)
		Laminin_G_2	386..517	CDD:280389	37/135 (27%)
		LamG	555..716	CDD:238058	53/226 (23%)
		EGF	746..777	CDD:278437	5/30 (17%)
		Laminin_G_2	814..945	CDD:280389	33/129 (26%)
		LamG	988..1136	CDD:238058
		EGF	1164..1195	CDD:278437
		Laminin_G_2	1233..1356	CDD:280389
lama4	NP_001034154.1	EGF_Lam	48..>84	CDD:238012
		Laminin_EGF	99..152	CDD:278482
		EGF_Lam	155..207	CDD:238012
		EGF_Lam	209..247	CDD:214543
		EGF_Lam	256..300	CDD:214543
		Laminin_I	351..611	CDD:283627
		SPEC	474..665	CDD:295325
		Laminin_II	790..919	CDD:283628
		LamG	893..1067	CDD:238058
		LamG	1104..1259	CDD:238058	43/153 (28%)
		LamG	1289..1422	CDD:238058	45/162 (28%)
		LamG	1535..1672	CDD:238058	46/152 (30%)
		LamG	1696..1847	CDD:238058	40/168 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910