DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nrx-1 and nrxn3a

DIOPT Version :9

Sequence 1:NP_001262840.1 Gene:Nrx-1 / 42646 FlyBaseID:FBgn0038975 Length:1847 Species:Drosophila melanogaster
Sequence 2:XP_021322866.1 Gene:nrxn3a / 563598 ZFINID:ZDB-GENE-070206-9 Length:1692 Species:Danio rerio


Alignment Length:1796 Identity:578/1796 - (32%)
Similarity:887/1796 - (49%) Gaps:267/1796 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 GFQLDGSQNSFYTFRKWYTGLNGTLELEFKTEQPNGLVLYTDDGGTYDFFELKLVEGALRLRYNL 168
            |.:..|.|..:..:.:|.......|..:|||:....|:||.||||..||.:|.:|||.|:|::::
Zfish    23 GLEFTGLQGQWARYLRWDASTRSDLSFQFKTDVSTALILYFDDGGFCDFLQLMVVEGKLQLQFSI 87

  Fly   169 GGGAQIITVGRELHDGHWHKVQVLRNDEQTSLIVDGVSQQRSTKGKEFQFGKFASNSDVYVGGMP 233
            ......:...:.::|..||...:.|.:.:|.|.:||||:....:... |:.|..  ||:::||:|
Zfish    88 DCAETTVVSDKRVNDSSWHSATLSRYNLRTVLGLDGVSKWAEVRPLR-QYMKIV--SDLFLGGVP 149

  Fly   234 NWYSSKLALLALPSVIFEPRFRGAIRNLVYADQPGGSTRRQEIKQQRDIKCGDVPCDHGELPARE 298
            .  ..::::|.||:|...|.|:|.||.|.|..:.......|.::..                   
Zfish   150 Q--DIRISVLTLPTVKDLPPFKGIIRELKYNSKEPILLSSQRVRMD------------------- 193

  Fly   299 RPLRGVRGGNTTDACERNDPCQHGGICISTDSGPICECRNLEYDGQYCEKE-------------- 349
              :.|:        |..| ||::||.|...|..|:|:|...||.|::|.:|              
Zfish   194 --IEGI--------CMEN-PCENGGTCSVVDGEPLCDCSKTEYVGRFCNEEANNIPGFAHMMMAD 247

  Fly   350 ----KAPSE--ATFRGTQFLSYDLGQTGAEPIVSAQDAISFYFRTRQPNGLLFYTGHGTDYLNLA 408
                ||..|  |||||::|..|||.|   .||.|:.|.|:..|:|.|.|||:.:||...||:|||
Zfish   248 QAKGKAREENVATFRGSEFFCYDLSQ---NPIQSSSDEITLSFKTWQRNGLILHTGKSADYVNLA 309

  Fly   409 LRDGGVSLTMGLANGKQEMHIKPSKVRFDDHQWHKVTVHRRIQEISSITSFCRLVTV-VDDVYTD 472
            |:||.|||.:.|.:|..|..::|...:|:|:.||.|.|.|.:::.|.|..  .:||: ||.:.|.
Zfish   310 LKDGAVSLVINLGSGAFEAIVEPVNGKFNDNSWHDVKVTRNLRQHSGIGH--AMVTISVDGILTT 372

  Fly   473 HSHIAGKFTMLSSSR-VYVGGAVNPRALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKL 536
            ..:....:|||.|.. .||||:.:...|.|:.|..||:|||::|.:..:.:.|.|..||:.....
Zfish   373 TGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIVDPK 437

  Fly   537 IQVAGNLEYQCPSGDPQDPVTFTTRESHLVLPPWETGKQSSISFKFRTKEPNGIIVLATGSKQPR 601
            :::.|::.::|.:....||::|.|.|:::.||.|.|.:..||||.|||.||||:|:...|..|.|
Zfish   438 MKIQGDVVFKCENVATLDPISFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQER 502

  Fly   602 -----AKNPVL--IAIELLNGHIYIHLDLGSGASKVRASRRRVDDGDWHDLILRRNGRDAKVSVD 659
                 .||..:  .|:|||:|.:|:.||:|||..||:|::.:|:||.|:.:.::|:||...:||:
Zfish   503 KDARSQKNTKVDFFAVELLDGSLYLLLDMGSGTIKVKATQNKVNDGAWYHVDIQRDGRSGTISVN 567

  Fly   660 GVWNDFRTPGDGTILELDGHMYLGGVGPAYNSVSWPAAIWTATLRQGFVGCLRDLVLSGKAIDIA 724
            .....|...|:..||:|:|.|||||:..:..|:..|..:|||.|..|:|||:|||.:.|::.||.
Zfish   568 SRRTPFTASGENEILDLEGDMYLGGLPDSRGSLILPTELWTAMLNYGYVGCIRDLFIDGRSKDIR 632

  Fly   725 AFARVQDSASVKPSCH-VQANVCNGNPCLNGGTCLEGWNRPICDCSATLYGGPTCGRELATLAFN 788
            ..|..|:.|.:||||: :....|:..||.|.|.|.|||||.||||:.|.|...||.||.:.|:::
Zfish   633 QIAEAQNGAGIKPSCNKMSGKQCDSYPCKNKGLCKEGWNRFICDCTGTGYWSRTCEREASILSYD 697

  Fly   789 GSQHMTIWLGNGQGTKTQTEELVIRFKTSRPAGLLLLTSAESNSPDRLEIALVAGRVRASVRL-- 851
            ||.:|.:.:....  .|:.|::.:||.:.|..|||:.|::. :|.|.|.:.|...||:.:|.|  
Zfish   698 GSMYMKVVMPTVM--HTEAEDVSLRFMSQRAYGLLMATTSR-DSADTLRLELDGSRVKLTVNLDC 759

  Fly   852 -------SDREKNLLAGQSVLNDNNWHTIRFSRRASNLRLQVDGAPPVRGMLSETILGRHSTMEI 909
                   |...:.|.|||. ||||.|||:|..||..:.:|.||.     .:....::|.|:.:|.
Zfish   760 IRINCNSSKGPETLYAGQK-LNDNEWHTVRVIRRGKSYKLTVDD-----DVAEGQMVGDHTRLEF 818

  Fly   910 RSVHLGGLFHAEEEIQMTSTMP-NFVGQMQGLVFNGQRYLDIVKSLGPELSALPSATFKLTARF- 972
            .::..|.:    .|.:..|.:| :|:|.:|.|.|||..|:|:.|:...:..       :|.||| 
Zfish   819 HNIETGVM----TERRFVSMIPSSFIGHLQSLKFNGLLYIDLCKNGDIDFC-------ELNARFG 872

  Fly   973 VNSPAGQPYHAATFRSKHSYVGLAMLKAYNSISIDFRFKTVEPNGLLVFNGGRRNDFVAVELVNG 1037
            :.|....|   .||:||:||:.||.|:||.|:.:.|:|||...:|.::||.|..:||:|||||.|
Zfish   873 MRSIIADP---VTFKSKNSYLSLATLQAYTSMHLFFQFKTTSADGFILFNSGDGSDFIAVELVKG 934

  Fly  1038 HIHYTFDLGDGPVTMRDKSRIHMNDNRWHQVSIRRPGPKTHTLTVDDSFEIISLTGNNMHLELAG 1102
            :|||.|:||:||..::..|...::||:||.|.|.|.....|||.| |:..:..:.....:|:|.|
Zfish   935 YIHYVFNLGNGPNVIKGNSERALHDNQWHNVVITRDNSNVHTLKV-DAKAVSQVVNGAKNLDLKG 998

  Fly  1103 ILYIGGVFKDMYSKLPASISSRSGFEGCLASLDLGDASPSLTSDAVVPSSLVVSGCE-------- 1159
            .|:|.|:..:||:.||..::||.||:|||||:||....|.|.:||:..|..:..|||        
Zfish   999 DLFIAGLGPNMYNNLPKLVASREGFKGCLASVDLNGRLPDLINDALFRSGQIERGCEASKNELGF 1063

  Fly  1160 ------GP-TKCSQNACANRGNCVQQWNAYACECDMTSYTGPTCYDESIAYEFGNNKGMVQYTFP 1217
                  || |.|.:::|||.|.|:|||..|.|:|.||||||..|.|....|.||...|::.:.:|
Zfish  1064 TKADLKGPSTTCQEDSCANMGICIQQWENYTCDCSMTSYTGTHCNDPGTTYIFGKGGGLISFNWP 1128

  Fly  1218 ENAQADTEEDNIALGFITTRPDAVLLRVESAT-TQDYMELEIVEGNIFMVYNIGSVDLPLGEIGT 1281
            .|.:..|..|.:.:||.|:..|.:|:|::||. ..||:.|.|.:|.|.:.:|||:.|:.:.|..|
Zfish  1129 ANERPSTRTDRLTVGFSTSLKDGILIRIDSAPGLGDYLMLHIEQGKIGVTFNIGTADITVQESST 1193

  Fly  1282 KVNDNAYHVVRFQRKGGNATLQLDDYNVQALTPQSHHS--------------------------- 1319
            .|||..||||||.|.|||||||:|::.:....|..:..                           
Zfish  1194 AVNDGKYHVVRFTRNGGNATLQVDNWAINEHFPSGNSDNERIQMANKKIPFKYARPVEEWLQEKG 1258

  Fly  1320 ---TVFNTMSNVQVGGKFSRNGRNRIERPFAGVIAGLSVNKLRILDLAVERDPHITIRGDVQLVT 1381
               |:|||.:.:.:||...:       |||.|.::||..|.|::|::|.:.:|:|.|.|.|:||.
Zfish  1259 RQLTIFNTQATITIGGSDRK-------RPFQGQLSGLYYNGLKVLNMAAQGNPNIKINGSVRLVG 1316

  Fly  1382 GVLDRNDLQ-----------------RMQQTLNSTRQTPASGYPGALDDLIFSGAGSGCRGDDED 1429
            .|......:                 .|..|.....:||.:  ....||::.|   :.|..||||
Zfish  1317 EVPAAGSARTTALPPEMSTTFIETTTTMSTTTTRKHRTPPT--IQTTDDMVSS---AECSSDDED 1376

  Fly  1430 --ECTPPFESGSGDDLITPVYV------------------PPTKQ-TTTSQQGNSLSTGGS---- 1469
              ||    |..:|.:|:.||.|                  |||.. ..|:::..|::|...    
Zfish  1377 FAEC----EGHAGGELVFPVIVKDPLELPSVATRTPSIPFPPTLTIIETTKESLSMATEAGVPCL 1437

  Fly  1470 SSGGVITNGTERACDDEDCVHGSGDYGETTEQFTSTSTARGSESNNEMVTITTTGRSDVTTEQHQ 1534
            |.||....|.:...||:|.:..|| || :.|.:.|.......|......::.|    |.|.    
Zfish  1438 SDGGSDDCGDDDDDDDDDGLMISG-YG-SGEAYDSNLPPTDDEDFYTTFSLVT----DKTL---- 1492

  Fly  1535 GSSSSSSSGSTPSYATTQSSSSSSSGGSAASTPGQVSTTSSVATSSTQRATSSSTSTSSSTTSTT 1599
              |||:..|...::|        ...||....|.:|..:....|:|.....|.||:||       
Zfish  1493 --SSSTFEGGYKAHA--------PKWGSKDFRPNKVFDSGRTTTASFSPKLSRSTTTS------- 1540

  Fly  1600 TTTTTTQATPPPEIRSTVTERETTPY-DIYIAGGGMGGSGRNDHDRMQLPDEHHPLPPLPPPIPP 1663
                    |||......:..||..|. ||.:.  .:..|...|:.:::.|....|:....|...|
Zfish  1541 --------TPPKLPAGKMNHRELKPQPDIVLL--PLPTSYEVDNTKLKSPLITSPMFRNVPTAIP 1595

  Fly  1664 QDPPPYGPYGGNTYNTNMNNYRPKGKGGRINSIEEERTAMIIGIVAGILIAVVLVILLVLWLKSN 1728
            .:|                ..|.......:.......|.|::||||...:. :|::|..::...|
Zfish  1596 TEP----------------GIRRVPGASEVVRESSSTTGMVVGIVAAAALC-ILILLYAMYKYRN 1643

  Fly  1729 GDRG-YKTESEKAAAYGSHNPNAALLGN--TSTNGSYHQQR 1766
            .|.| |:.:..:.....|...|.|::.:  .||.....:|:
Zfish  1644 RDEGSYQVDETRNYITNSAQSNGAVMKDKQQSTKSGNKKQK 1684

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nrx-1NP_001262840.1 LamG 110..263 CDD:238058 48/152 (32%)
EGF_CA 311..347 CDD:238011 14/35 (40%)
Laminin_G_2 386..517 CDD:280389 54/132 (41%)
LamG 555..716 CDD:238058 72/167 (43%)
EGF 746..777 CDD:278437 17/30 (57%)
Laminin_G_2 814..945 CDD:280389 45/140 (32%)
LamG 988..1136 CDD:238058 66/147 (45%)
EGF 1164..1195 CDD:278437 18/30 (60%)
Laminin_G_2 1233..1356 CDD:280389 50/153 (33%)
nrxn3aXP_021322866.1 LamG 23..178 CDD:238058 50/159 (31%)
EGF 198..>221 CDD:306513 10/23 (43%)
LamG 282..421 CDD:214598 55/140 (39%)
LamG 478..627 CDD:214598 64/148 (43%)
EGF_CA 655..688 CDD:238011 18/32 (56%)
LamG 716..850 CDD:214598 45/144 (31%)
Laminin_G_2 907..1035 CDD:308045 57/128 (45%)
EGF_CA 1075..1107 CDD:238011 18/31 (58%)
LamG 1113..1291 CDD:238058 59/184 (32%)
Syndecan 1618..>1653 CDD:307260 11/35 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 133 1.000 Domainoid score I5005
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H83225
Inparanoid 1 1.050 862 1.000 Inparanoid score I406
OMA 1 1.010 - - QHG46386
OrthoDB 1 1.010 - - D24127at33208
OrthoFinder 1 1.000 - - FOG0001168
OrthoInspector 1 1.000 - - otm24728
orthoMCL 1 0.900 - - OOG6_103392
Panther 1 1.100 - - O PTHR15036
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X794
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1312.980

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