DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-1 and cntnap2b

DIOPT Version :9

Sequence 1:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster
Sequence 2:	NP_001289171.1	Gene:	cntnap2b / 563345	ZFINID:	ZDB-GENE-070912-26	Length:	1315	Species:	Danio rerio

Alignment Length:	1125	Identity:	260/1125 - (23%)
Similarity:	440/1125 - (39%)	Gaps:	237/1125 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   356 TFRGTQFLSYDLGQTGAEPIVSAQDAISFYFRTRQPNGLLFY-TGHGTDYLNLALRDGGVSLTMG 419
            :|.|...:||...|   :.:...:|.||..|:|.:.:|:|.: .|...||:.|.||...:.|.:.
Zfish   183 SFDGQGVISYRFRQ---KKMKILKDVISLKFKTSKGDGVLLHGEGQQGDYITLELRRAKLQLQIN 244

  Fly   420 LAN---GKQEMHIKPSK-VRFDDHQWHKVTVHRRIQEISSITSFCRLVTVVDDVYTDHSHIAGKF 480
            |.:   |..:.|...|. ...||.|||.|.:.|          :.|.:....|.:.......|:|
Zfish   245 LGSNQYGSIQGHTSASSGSLLDDDQWHSVLIER----------YRRSINFTLDQHKQSFRTNGEF 299

  Fly   481 TMLS-SSRVYVGG-AVNPRALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNL 543
            ..|. ...:..|| .|:.:...|.|  .|::||:..:.::.|    |:.:||:..........||
Zfish   300 DHLDLDYEITFGGMPVSAKPSSGGR--ENYIGCMEAIHYNGD----NITNLARRRKVDTSSFHNL 358

  Fly   544 EYQCPSGDPQDPVTFTTRESHLVLPPWETGKQSSISFKFRTKEPNGIIVLATGSKQPRAKNPVL- 607
            .:.|.  :.:....|....|.|.||........|:..:|||..|:|::..          .|::
Zfish   359 TFSCT--ESRTFPAFFNSTSSLQLPGRTDADTVSVRLQFRTWNPSGLLFF----------TPLMP 411

  Fly   608 --IAIELLNG----HIYIHL------DLGSGASKVRASRRRVDDGDWHDL---------ILRRNG 651
              :.:.|:.|    |||:.|      |:.||:.        ::||.||.:         :|..||
Zfish   412 GGVEVSLVEGKVTVHIYVTLGKNTRVDISSGSG--------LNDGQWHSVHFLALESIAMLTING 468

  Fly   652 RDAKVSVDGVWNDFRTPGDGTILELDGHMYLGGVGPAYNSVSWPAAIWTATLRQGFVGCLRDLVL 716
            .:.......:....||.||         .:.||..|..:         .:..::.|.||::.:.:
Zfish   469 DEMSTVRAALPMQIRTGGD---------YFFGGYFPRTD---------LSPSQRSFQGCMQLIHV 515

  Fly   717 SGKAID--------IAAFARVQ-DSASVKPSCHVQANVCNGNPCLNGGTCLEGWNRPICDCSATL 772
            ..:.:|        :.:|..|. |..::       .:.|..|.|.:||.|.:..:...|.|..|.
Zfish   516 DDQFMDLQSVEQGVLGSFENVSLDMCAI-------IDRCVPNHCEHGGKCSQTEDTFKCACEGTG 573

  Fly   773 YGGPTCGRELATLAFNGSQHM-----TIWLG-NGQGT--------KTQTEELVIRFKTSRPAGLL 823
            |.|.||...:...:....:|:     |.|:. :|.|:        ..:.:::........||...
Zfish   574 YSGATCHNSVYEQSCEEYKHLGRSSDTYWIDPDGSGSLEPFRVTCNMKEDKVWTTIANDLPAQSS 638

  Fly   824 LLTSAESNSPDRLEIALVAGRVRASVRLSDREKNLLAGQSVLNDNNWHTIRFSRRASNLRLQVDG 888
            :  ||.|...|:..:.|       :..:|..:.|.:...:.|.:.  |......::..||:....
Zfish   639 V--SAGSVPEDKTVLTL-------NYSMSTEQVNAITSSAELCEQ--HVSYMCYKSQLLRVPSPD 692

  Fly   889 APPVRGMLSETILGRHSTMEIRSVHLGGLFHAEEE----IQMTSTMPNF--------------VG 935
            .||     |...:||.:.   :..:.||.....::    |:...|.|.:              .|
Zfish   693 VPP-----STYWVGRGNE---KHFYWGGSGPGVQKCACGIERNCTDPRYYCNCDADLRQWKEDAG 749

  Fly   936 QMQ-------GLVFNGQRYLDIVKSLGPELSALPSATFKLTARFVNSPAGQPY-HAATFRSKHSY 992
            .:.       ..|..|    ||.:| |.|.        |||...:.....:.| :||:|.:..||
Zfish   750 MLMYKDHLPVSQVVVG----DIYRS-GSEA--------KLTVGPLRCQGDRHYWNAASFNTPASY 801

  Fly   993 VGLAMLKAYNSISIDFRFKTVEPNGLLVFNGGRRNDFVAVELVNGH-IHYTFDLGDGPVTMRDKS 1056
            :....|:|..|..:.|.|||...:|:.:.|.| ..||:.:||.:.. :.::||:|:|.|.:..:|
Zfish   802 LHFPTLQAETSADVSFYFKTSASHGVFLENLG-NPDFIRLELSSASVVSFSFDVGNGLVELSVRS 865

  Fly  1057 RIHMNDNRWHQVSIRRPGPKTHTLTVDDSFEIISLTGNNMH--LELAGILYIGGVFKDMYSKLPA 1119
            ...:||::||:|...| ..|...|.||..:..........|  |.|...|::|           |
Zfish   866 STPLNDDQWHRVEAER-NIKEAVLRVDKLYREARSAPPQGHTRLRLFSQLFVG-----------A 918

  Fly  1120 SISSRSGFEGCLASLDLGDASPSLTSDA-VVPSSLVVSGCEGPTKCSQNA--CANRGNCVQQWNA 1181
            |...| ||.||:.||.:...:..|...| |.|.  |..||.|  .||...  |.|.|.|::::|.
Zfish   919 SGGQR-GFLGCIRSLKVNGVTLDLEGRAKVTPG--VKPGCSG--HCSSYGMHCQNGGKCIEKYNG 978

  Fly  1182 YACECDMTSYTGPTCYDESIAY-EFGNNKGMVQYTFPENAQADT----EEDNIALG--------- 1232
            |:|:|..|::.||.|.|:...| |.|.   :|::.....:...:    |.::..||
Zfish   979 YSCDCSQTAFDGPFCNDDVGGYFESGT---LVRFDLMSESSTSSPALKEGESAVLGIVGNLTHEE 1040

  Fly  1233 ----FITTRPDAVLLRVESATTQDYMELEI-VEGNIFMVYNIGSVDLPLGEIGTKVN-----DNA 1287
                |.|:...||.:.: |:.||||:.:.: ..|.:.:.||:|.:..|   ....:|     :..
Zfish  1041 LSFSFSTSNTPAVPIYI-SSKTQDYLAVVLRHNGTLQIRYNLGGLKEP---FSISLNHRNMANGQ 1101

  Fly  1288 YHVVRFQRKGGNATLQLDDYNVQALTPQSHHSTVFNTMSNVQVGGKFSRNGR------NRIERP- 1345
            .|.|...|:..:..||:|.|...:.|......|.||.:..:.: ||....|:      .|...|
Zfish  1102 PHNVNISRQERHIQLQVDHYPTASYTLPEASDTEFNLVKTIFL-GKVFETGQIDPVLIERYNTPG 1165

  Fly  1346 FAGVIAGLSVNKLRILDLAV 1365
            |.|.::.:..|::..|..|:
Zfish  1166 FVGCLSRVQFNRISPLKAAL 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058
		EGF_CA	311..347	CDD:238011
		Laminin_G_2	386..517	CDD:280389	35/137 (26%)
		LamG	555..716	CDD:238058	38/182 (21%)
		EGF	746..777	CDD:278437	11/30 (37%)
		Laminin_G_2	814..945	CDD:280389	25/155 (16%)
		LamG	988..1136	CDD:238058	46/150 (31%)
		EGF	1164..1195	CDD:278437	12/32 (38%)
		Laminin_G_2	1233..1356	CDD:280389	33/135 (24%)
cntnap2b	NP_001289171.1	FA58C	33..174	CDD:238014
		FA58C	44..175	CDD:214572
		Laminin_G_2	210..338	CDD:280389	35/139 (25%)
		Laminin_G_2	395..518	CDD:280389	32/158 (20%)
		EGF_CA	544..579	CDD:238011	11/34 (32%)
		LamG	792..935	CDD:238058	49/156 (31%)
		EGF_CA	959..993	CDD:238011	13/33 (39%)
		LamG	1040..1177	CDD:214598	33/141 (23%)
		4.1m	1266..1284	CDD:128590
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910