Protein Alignment Nrx-1 and nrxn2b

DIOPT Version :10

• Sequence 1: NP_001262840.1
• Gene: Nrx-1 / 42646
• FlyBaseID: FBgn0038975
• Length: 1847
• Species: Drosophila melanogaster
• Sequence 2: XP_073762801.1
• Gene: nrxn2b / 560420
• ZFINID: ZDB-GENE-070206-7
• Length: 1678
• Species: Danio rerio
• Alignment Length: 1850
• Identity: 601/1850 - (32%)
• Similarity: 881/1850 - (47%)
• Gaps: 357/1850 - (19%)

  Fly    81 SYRVLIVSALLVSLAASFVTLSAGFQLDGSQNSFYTFRKWYTGLNGTLELEFKTEQPNGLVLYTD 145
            |.||..|..||:    |.|.:.|..:..|:...:..:.:|..|..|.|....||.....||||.|
Zfish     3 SRRVFWVCVLLL----SGVCVCASLEFGGAPGQWARYSRWEAGSVGELSFSLKTNISKALVLYLD 63

  Fly   146 DGGTYDFFELKLVEGALRLRYNLGGGAQIITVGRE--LHDGHWHKVQVLRNDEQTSLIVDGVSQQ 208
            |||..||.||.:..|.|.||:.: ..|:..|:..|  :.|..||.|.:.||..||.|:|||.::.
Zfish    64 DGGNCDFLELLISGGVLHLRFAI-HCAEPATLQTETRVSDDRWHMVLLTRNYRQTLLMVDGEARA 127

  Fly   209 RSTKGKEFQFGKFASNSDVYVGGMPNWYSSKLALLALPSVIFEPRFRGAIRNLVYADQPGGSTRR 273
            ...:.|.   .:.|..||::|||:|.  ..:|:.|...:|.:||.|.|.|.||
Zfish   128 AEVRSKR---REMAVVSDLFVGGIPP--DVRLSALTSSTVKYEPPFLGLISNL------------ 175

  Fly   274 QEIKQQRDIKCGDVP----CDHG-----ELPARERPLRGVRGGNTTDACERNDPCQHGGICISTD 329
                     |.|::|    ..||     ||                 .|.:.:||.:||:| |..
Zfish   176 ---------KLGEIPPALINSHGIHSDLEL-----------------LCSKQNPCLNGGVC-SVQ 213

  Fly   330 SGPI-CECRNLEYDGQYCEK------------------EKAP------SEATFRGTQFLSYDLGQ 369
            .|.: |:|.:..:.|:||::                  :.||      |.|||:|.:|..|||..
Zfish   214 FGEVQCDCSHTRFRGKYCKEAEEYAVEGLAHLTLNSQGDSAPAAGKEESVATFKGNEFFCYDLSL 278

  Fly   370 TGAEPIVSAQDAISFYFRTRQPNGLLFYTGHGTDYLNLALRDGGVSLTMGLANGKQEMHIKPSKV 434
            |   ||.|:.|.|:..|||.|.|||:.:||...||:||:|:.|.|.|.:.|.:|..|..::|...
Zfish   279 T---PIQSSTDEITLSFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVNG 340

  Fly   435 RFDDHQWHKVTVHRRIQEISSI-----TSFCRLVTV-VDDVYTDHSHIAGKFTMLSSSR-VYVGG 492
            :|:|:.||.|.|.|.:::.|.|     .....:||: ||.:.|...:....:|||.|.. .|:||
Zfish   341 KFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHYMVTISVDGILTTTGYTQEDYTMLGSDDFFYIGG 405

  Fly   493 AVNPRALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQCPSGDPQDPVT 557
            :.|...|.|:.|..||:|||:.|.:..:...|.|..||......|.:.|.|.::|......||||
Zfish   406 SPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAIERDPKISLHGELVFRCEDVAALDPVT 470

  Fly   558 FTTRESHLVLPPWETGKQSSISFKFRTKEPNGIIVLA----TGSKQPRAKNPV---LIAIELLNG 615
            |.|.:|.:.||.|:|.|.|||||.|||.||:|:::.:    .|||:.|.....   ..|:|||:|
Zfish   471 FETPDSFISLPRWDTKKTSSISFDFRTSEPSGLLLFSHGRPQGSKETRPGRETKSDYFAMELLDG 535

  Fly   616 HIYIHLDLGSGASKVRASRRRVDDGDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTILELDGHM 680
            .:|:.:|:|||:.|::||.::|:||:|..:..:|.||...:||:.....|.|.....||:||..|
Zfish   536 FLYLLMDMGSGSIKIKASNKKVNDGEWCHVDFQREGRRGSISVNSRSMPFSTNEGSEILDLDSDM 600

  Fly   681 YLGGVGPAYNSVSWPAAIWTATLRQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSC--HVQA 743
            ||||:......:..|..:|||.|..|:|||:|||.:.||:.|:...|.:|.:..|...|  .:|.
Zfish   601 YLGGLPEMRQGLVLPPEVWTALLNYGYVGCVRDLFIDGKSRDVRRLAEIQSAPGVSSFCTRELQK 665

  Fly   744 NVCNGNPCLNGGTCLEGWNRPICDCSATLYGGPTCGRELATLAFNGSQHMTIWLGNGQGTKTQTE 808
            . |:..||.|||.|.|||||.||||:.|.|.|..|..|...|:::||.::.|.|.:  ...|:.|
Zfish   666 R-CSSAPCANGGQCKEGWNRYICDCTGTGYMGSNCEIEATVLSYDGSMYLKILLPS--TLHTEAE 727

  Fly   809 ELVIRFKTSRPAGLLLLTSAESNSPDRLEIALVAGRVRASV---------RLSDREKNLLAGQSV 864
            ::.:||.:.|..|||:.|::: .|.|.|.:.|..|||:.:|         .||...:.|.|||.
Zfish   728 DVSLRFMSQRAYGLLMATTSK-ESADTLRLELDGGRVKLTVNLDCIRIDCNLSKGPEMLTAGQK- 790

  Fly   865 LNDNNWHTIRFSRRASNLRLQVDGAPPVRGMLSETILGRHSTMEIRSVHLGGLFHAEEEIQMTST 929
            ||||.||:::..||..||:|.||.. .|.|.::    |.|:.:|..|:..|.:    .|.:..|.
Zfish   791 LNDNEWHSVKVVRRGRNLQLSVDNV-TVEGQMT----GDHTRLEFHSIETGIM----TERRFISV 846

  Fly   930 MP-NFVGQMQGLVFNGQRYLDIVKSLGPELSALPSATFKLTARF-----VNSPAGQPYHAATFRS 988
            :| ||:|.:|||:.||..|||..|:  .::|..     :|.|||     :..|       .||||
Zfish   847 VPSNFIGHLQGLLLNGVPYLDQCKN--GDISYC-----ELNARFGLRHIIADP-------ITFRS 897

  Fly   989 KHSYVGLAMLKAYNSISIDFRFKTVEPNGLLVFNGGRRNDFVAVELVNGHIHYTFDLGDGPVTMR 1053
            |.||:.||.|:||.|:.:.|:|||...:||::||.|..:||:.||||.|.:||.||||:||..|:
Zfish   898 KGSYLALATLQAYASMHLFFQFKTTGSDGLMLFNSGDGSDFIVVELVKGFVHYVFDLGNGPSLMK 962

  Fly  1054 DKSRIHMNDNRWHQVSIRRPGPKTHTLTVDDSFEIISLTGNNMHLELAGILYIGGVFKDMYSKLP 1118
            ..|...:|||:||.|.:.|.....|||.: ||..:...:....:|:|.|.||||||.|.||:.||
Zfish   963 GNSEKPLNDNQWHNVVVSRDTNNVHTLKI-DSRTVTQHSNGARNLDLKGELYIGGVAKSMYNSLP 1026

  Fly  1119 ASISSRSGFEGCLASLDLGDASPSLTSDAVVPSSLVVSGCEGPTK-CSQNACANRGNCVQQWNAY 1182
            ..|:||.|::|||||:||....|.|.:||:.....|..||:||:. ||:::|.::|.|:|||..:
Zfish  1027 KLIASRDGYQGCLASIDLNGRLPDLLADALHKVGQVDRGCDGPSSTCSEDSCLHQGVCLQQWEGF 1091

  Fly  1183 ACECDMTSYTGPTCYDESIAYEFGNNKGMVQYTFPENAQADTEEDNIALGFITTRPDAVLLRVES 1247
            :|:|.||||.|..|.|....|.||....::.||:|.|.:..|..|.:|:||.:...:|||:||||
Zfish  1092 SCDCTMTSYGGSYCSDPGTTYIFGRGGALITYTWPPNDRPSTRADRLAVGFSSQLKEAVLVRVES 1156

  Fly  1248 AT-TQDYMELEIVEGNIFMVYNIGSVDLPLGEIGTKVNDNAYHVVRFQRKGGNATLQLDDYNV-- 1309
            |. ..||:||.|..|.:.:::|:|:.|:.:.|.|..|:|..||||||.|.|||||||:|:..|
Zfish  1157 AKGLGDYLELHIERGRVGVIFNVGTDDIVIEESGVMVSDGKYHVVRFTRSGGNATLQVDNLPVIE 1221

  Fly  1310 ----------------------------QALTPQSHHSTVFNTMSNVQVGGKFSRNGRNRIERPF 1346
                                        :.|..:....|:||:.:.::|||  ...|||     |
Zfish  1222 RFPAGNFDSERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAFIKVGG--GEKGRN-----F 1279

  Fly  1347 AGVIAGLSVNKLRILDLAVERDPHITIRGDVQLV--------TGVLDRNDLQRMQQTLNSTRQTP 1403
            .|.|:||..|.|::|.||.|.||::.|:|:::||        |.......|..|..|:..|..|.
Zfish  1280 QGQISGLYYNGLQVLKLAAEADPNVQIQGNLRLVGDTPSVMTTDTTSTTPLADMSTTIMETTTTM 1344

  Fly  1404 AS-------------GYPGALDDLIFSGAGSGCRGDDED--ECTPPFESGSGDDLITPVYV---- 1449
            |:             ......|||:.  |.:.|..||||  ||.|    |:|.:|:.|:..
Zfish  1345 ATTTTRKQRSPTMRDSVTQNTDDLLV--ASAECPSDDEDLEECEP----GNGGELVLPIITVDSL 1403

  Fly  1450 --------------PPTKQ---TTTSQQGNSLSTGGSSSGGVITNGTERAC--DDEDC------- 1488
                          |||.:   |.......|:...|           ...|  |.|||
Zfish  1404 EPPSIATRYPVIPPPPTYRPFLTLLETTKESVPLPG-----------RHPCPLDQEDCEEPMEVS 1457

  Fly  1489 VHGSGDYGETTEQFTSTSTARGSESNNEMVTITTT-----GRSDVTTEQHQGSSSSSSSGSTPSY 1548
            .:|||:..|:.::        ....|:.:||..|.     |..:...::......:|.....|..
Zfish  1458 AYGSGEMTESDDE--------DYYKNSPLVTDRTVLPPPPGAGNPRGDRPFARLPNSHRPPLPLT 1514

  Fly  1549 ATTQSSSSSSSGGSAASTP-GQVSTTSSVATSSTQRATSSSTSTSSSTTSTTTTTTTTQATPPPE 1612
            .|....|....|.:|.:.| |:::|...|                              ..||.:
Zfish  1515 PTAPPVSRLKPGINAPNIPAGKMNTRDQV------------------------------LLPPAQ 1549

  Fly  1613 IRSTVTERETTPYDIYIAGGGMGGSGRNDHDRMQLPDEHHPLPPLPPPIPPQDP--PPYGPYGGN 1675
                             ..|....|||:.|    :|...:  ||..|.:|..||  |..||
Zfish  1550 -----------------PSGDTDHSGRHRH----IPGITY--PPNFPHVPTTDPSSPDRGP---- 1587

  Fly  1676 TYNTNMNNYRPKGKGGRINSIEE--ERTAMIIGIVAGILIAVVLVILLVLWLKSNGDRG-YKTES 1737
                          .|.:..|.|  ..|.|::||||...:. :|::|..::...|.|.| |:.:.
Zfish  1588 --------------PGAVEVIRESSSTTGMVVGIVAAAALC-ILILLYAMYKYRNRDEGSYQVDQ 1637

  Fly  1738 EKAAAYGSHNPNAALLGNTSTNGSYHQQRQ 1767
            .:     ::..|:|    |.:||:..:::|
Zfish  1638 SR-----NYISNSA----TQSNGALVKEKQ 1658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058	55/154 (36%)
		EGF_CA	311..347	CDD:238011	12/36 (33%)
		Laminin_G_2	386..517	CDD:460494	52/137 (38%)
		LamG	555..716	CDD:238058	71/167 (43%)
		EGF	746..777	CDD:394967	19/30 (63%)
		Laminin_G_2	814..945	CDD:460494	50/140 (36%)
		Laminin_G_2	1010..1138	CDD:460494	62/127 (49%)
		Laminin_G_2	1233..1356	CDD:460494	53/153 (35%)
nrxn2b	XP_073762801.1	None