DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-1 and nrxn2b

DIOPT Version :9

Sequence 1:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster
Sequence 2:	NP_001073453.1	Gene:	nrxn2b / 560420	ZFINID:	ZDB-GENE-070206-7	Length:	1586	Species:	Danio rerio

Alignment Length:	1817	Identity:	572/1817 - (31%)
Similarity:	843/1817 - (46%)	Gaps:	383/1817 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 SYRVLIVSALLVSLAASFVTLSAGFQLDGSQNSFYTFRKWYTGLNGTLELEFKTEQPNGLVLYTD 145
            |.||..|..||:    |.|.:.|..:..|:...:..:.:|..|..|.|....||.....||||.|
Zfish     3 SRRVFWVCVLLL----SGVCVCASLEFGGAPGQWARYSRWEAGSVGELSFSLKTNISKALVLYLD 63

  Fly   146 DGGTYDFFELKLVEGALRLRYNLGGGAQIITVGRE--LHDGHWHKVQVLRNDEQTSLIVDGVSQQ 208
            |||..||.||.:..|.|.||:.: ..|:..|:..|  :.|..||.|.:.||..||.|:|||.::.
Zfish    64 DGGNCDFLELLISGGVLHLRFAI-HCAEPATLQTETRVSDDRWHMVLLTRNYRQTLLMVDGEARA 127

  Fly   209 RSTKGKEFQFGKFASNSDVYVGGMPNWYSSKLALLALPSVIFEPRFRGAIRNLVYADQPGGSTRR 273
            ...:.|.   .:.|..||::|||:|.  ..:|:.|...:|.:||.|.|.|.||
Zfish   128 AEVRSKR---REMAVVSDLFVGGIPP--DVRLSALTSSTVKYEPPFLGLISNL------------ 175

  Fly   274 QEIKQQRDIKCGDVP----CDHG-----ELPARERPLRGVRGGNTTDACERNDPCQHGGICISTD 329
                     |.|::|    ..||     ||                 .|.:.:||.:||:| |..
Zfish   176 ---------KLGEIPPALINSHGIHSDLEL-----------------LCSKQNPCLNGGVC-SVQ 213

  Fly   330 SGPI-CECRNLEYDGQYCEKEKAPSEATFRGTQFLSYDLGQTGAEPIVSAQDAISFYFRTRQPNG 393
            .|.: |:|.:..:.|:||   |.|.                  ::||.|:.|.|:..|||.|.||
Zfish   214 FGEVQCDCSHTRFRGKYC---KEPV------------------SDPIQSSTDEITLSFRTLQRNG 257

  Fly   394 LLFYTGHGTDYLNLALRDGGVSLTMGLANGKQEMHIKPSKVRFDDHQWHKVTVHRRIQEISSI-- 456
            |:.:||...||:||:|:.|.|.|.:.|.:|..|..::|...:|:|:.||.|.|.|.:::.|.|
Zfish   258 LMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGH 322

  Fly   457 ---TSFCRLVTV-VDDVYTDHSHIAGKFTMLSSSR-VYVGGAVNPRALLGARVHTNFVGCLRKVE 516
               .....:||: ||.:.|...:....:|||.|.. .|:||:.|...|.|:.|..||:|||:.|.
Zfish   323 AMVNKLHYMVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVV 387

  Fly   517 FSADTLNLNLIDLAKSGSKLIQVAGNLEYQCPSGDPQDPVTFTTRESHLVLPPWETGKQSSISFK 581
            :..:...|.|..||......|.:.|.|.::|......|||||.|.:|.:.||.|:|.|.|||||.
Zfish   388 YKNNDFKLELSRLAIERDPKISLHGELVFRCEDVAALDPVTFETPDSFISLPRWDTKKTSSISFD 452

  Fly   582 FRTKEPNGIIVLA----TGSKQPRAKNPV---LIAIELLNGHIYIHLDLGSGASKVRASRRRVDD 639
            |||.||:|:::.:    .|||:.|.....   ..|:|||:|.:|:.:|:|||:.|::||.::|:|
Zfish   453 FRTSEPSGLLLFSHGRPQGSKETRPGRETKSDYFAMELLDGFLYLLMDMGSGSIKIKASNKKVND 517

  Fly   640 GDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTILELDGHMYLGGVGPAYNSVSWPAAIWTATLR 704
            |:|..:..:|.||...:||:.....|.|.....||:||..|||||:......:..|..:|||.|.
Zfish   518 GEWCHVDFQREGRRGSISVNSRSMPFSTNEGSEILDLDSDMYLGGLPEMRQGLVLPPEVWTALLN 582

  Fly   705 QGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSC--HVQANVCNGNPCLNGGTCLEGWNRPICD 767
            .|:|||:|||.:.||:.|:...|.:|.:..|...|  .:|.. |:..||.|||.|.|||||.|||
Zfish   583 YGYVGCVRDLFIDGKSRDVRRLAEIQSAPGVSSFCTRELQKR-CSSAPCANGGQCKEGWNRYICD 646

  Fly   768 CSATLYGGPTCGRELATLAFNGSQHMTIWLGNGQGTKTQTEELVIRFKTSRPAGLLLLTSAESNS 832
            |:.|.|.|..|..|...|:::||.::.|.|.:  ...|:.|::.:||.:.|..|||:.|::: .|
Zfish   647 CTGTGYMGSNCEIEATVLSYDGSMYLKILLPS--TLHTEAEDVSLRFMSQRAYGLLMATTSK-ES 708

  Fly   833 PDRLEIALVAGRVRASVRLSDREKNLLAGQSVLNDNNWHTIRFSRRASNLRLQVDGAPPVRGMLS 897
            .|.|.:.|..|||:.:|.|         ||
Zfish   709 ADTLRLELDGGRVKLTVNL---------GQ----------------------------------- 729

  Fly   898 ETILGRHSTMEIRSVHLGGLFHAEEEIQMTSTMP-NFVGQMQGLVFNGQRYLDIVKSLGPELSAL 961
              :.|.|:.:|..|:..|.:    .|.:..|.:| ||:|.:|||:.||..|||..|:  .::|..
Zfish   730 --MTGDHTRLEFHSIETGIM----TERRFISVVPSNFIGHLQGLLLNGVPYLDQCKN--GDISYC 786

  Fly   962 PSATFKLTARF-----VNSPAGQPYHAATFRSKHSYVGLAMLKAYNSISIDFRFKTVEPNGLLVF 1021
                 :|.|||     :..|       .|||||.||:.||.|:||.|:.:.|:|||...:||::|
Zfish   787 -----ELNARFGLRHIIADP-------ITFRSKGSYLALATLQAYASMHLFFQFKTTGSDGLMLF 839

  Fly  1022 NGGRRNDFVAVELVNGHIHYTFDLGDGPVTMRDKSRIHMNDNRWHQVSIRRPGPKTHTLTVDDSF 1086
            |.|..:||:.||||.|.:||.||||:||..|:..|...:|||:||.|.:.|.....|||.: ||.
Zfish   840 NSGDGSDFIVVELVKGFVHYVFDLGNGPSLMKGNSEKPLNDNQWHNVVVSRDTNDVHTLKI-DSR 903

  Fly  1087 EIISLTGNNMHLELAGILYIGGVFKDMYSKLPASISSRSGFEGCLASLDLGDASPSLTSDAVVPS 1151
            .:...:....:|:|.. ||||||.|.||:.||..|:||.|::|||||:||....|.|.:||:...
Zfish   904 TVTQHSNGARNLDLRE-LYIGGVAKSMYNSLPKLIASRDGYQGCLASIDLNGRLPDLLADALHKV 967

  Fly  1152 SLVVSGCEGPTK-CSQNACANRGNCVQQWNAYACECDMTSYTGPTCYDESIAYEFGNNKGMVQYT 1215
            ..|..||:||:. ||:::|.::|.|:|||..::|:|.||||.|..|.|....|.||....::.||
Zfish   968 GQVDRGCDGPSSTCSEDSCLHQGVCLQQWEGFSCDCTMTSYGGSYCSDPGTTYIFGRGGALITYT 1032

  Fly  1216 FPENAQADTEEDNIALGFITTRPDAVLLRVESAT-TQDYMELEIVEGNIFMVYNIGSVDLPLGEI 1279
            :|.|.:..|..|.:|:||.:...:|||:|||||. ..||:||.|..|.:.:::|:|:.|:.:.|.
Zfish  1033 WPPNDRPSTRADRLAVGFSSQLKEAVLVRVESAKGLGDYLELHIERGRVGVIFNVGTDDIVIEES 1097

  Fly  1280 GTKVNDNAYHVVRFQRKGGNATLQLDDYNV------------------------------QALTP 1314
            |..|:|..||||||.|.|||||||:|:..|                              :.|..
Zfish  1098 GVMVSDGKYHVVRFTRSGGNATLQVDNLPVIERFPAGNFDSERLAIARQRIPYRLGRVVDEWLLD 1162

  Fly  1315 QSHHSTVFNTMSNVQVGGKFSRNGRNRIERPFAGVIAGLSVNKLRILDLAVERDPHITIRGDVQL 1379
            :....|:||:.:.::|||  ...|||     |.|.|:||..|.|::|.||.|.||::.|:|:::|
Zfish  1163 KGRQLTIFNSQAFIKVGG--GEKGRN-----FQGQISGLYYNGLQVLKLAAEADPNVQIQGNLRL 1220

  Fly  1380 V--------TGVLDRNDLQRMQQTLNSTRQTPAS-------------GYPGALDDLIFSGAGSGC 1423
            |        |.......|..|..|:..|..|.|:             ......|||:.  |.:.|
Zfish  1221 VGDTPSVMTTDTTSTTPLADMSTTIMETTTTMATTTTRKQRSPTMRDSVTQNTDDLLV--ASAEC 1283

  Fly  1424 RGDDED--ECTPPFESGSGDDLITPVYV------------------PPTKQ---TTTSQQGNSLS 1465
            ..||||  ||.|    |:|.:|:.|:..                  |||.:   |.......|:.
Zfish  1284 PSDDEDLEECEP----GNGGELVLPIITVDSLEPPSIATRYPVIPPPPTYRPFLTLLETTKESVP 1344

  Fly  1466 TGGSSSGGVITNGTERAC--DDEDC-------VHGSGDYGETTEQFTSTSTARGSESNNEMVTIT 1521
            ..|           ...|  |.|||       .:|||:..|:.::        ....|:.:||..
Zfish  1345 LPG-----------RHPCPLDQEDCEEPMEVSAYGSGEMTESDDE--------DYYKNSPLVTDR 1390

  Fly  1522 TT-----GRSDVTTEQHQGSSSSSSSGSTPSYATTQSSSSSSSGGSAASTP-GQVSTTSSVATSS 1580
            |.     |..:...::......:|.....|...|....|....|.:|.:.| |:::|...|
Zfish  1391 TVLPPPPGAGNPRGDRPFARLPNSHRPPLPLTPTAPPVSRLKPGINAPNIPAGKMNTRDQV---- 1451

  Fly  1581 TQRATSSSTSTSSSTTSTTTTTTTTQATPPPEIRSTVTERETTPYDIYIAGGGMGGSGRNDHDRM 1645
                                      ..||.:                 ..|....|||:.|
Zfish  1452 --------------------------LLPPAQ-----------------PSGDTDHSGRHRH--- 1470

  Fly  1646 QLPDEHHPLPPLPPPIPPQDP--PPYGPYGGNTYNTNMNNYRPKGKGGRINSIEE--ERTAMIIG 1706
             :|...:  ||..|.:|..||  |..||                  .|.:..|.|  ..|.|::|
Zfish  1471 -IPGITY--PPNFPHVPTTDPSSPDRGP------------------PGAVEVIRESSSTTGMVVG 1514

  Fly  1707 IVAGILIAVVLVILLVLWLKSNGDRG-YKTESEKAAAYGSHNPNAALLGNTSTNGSYHQQRQ 1767
            |||...:. :|::|..::...|.|.| |:.:..:     ::..|:|    |.:||:..:::|
Zfish  1515 IVAAAALC-ILILLYAMYKYRNRDEGSYQVDQSR-----NYISNSA----TQSNGALVKEKQ 1566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058	55/154 (36%)
		EGF_CA	311..347	CDD:238011	12/36 (33%)
		Laminin_G_2	386..517	CDD:280389	52/137 (38%)
		LamG	555..716	CDD:238058	71/167 (43%)
		EGF	746..777	CDD:278437	19/30 (63%)
		Laminin_G_2	814..945	CDD:280389	32/131 (24%)
		LamG	988..1136	CDD:238058	70/147 (48%)
		EGF	1164..1195	CDD:278437	15/30 (50%)
		Laminin_G_2	1233..1356	CDD:280389	53/153 (35%)
nrxn2b	NP_001073453.1	LamG	22..177	CDD:238058	56/181 (31%)
		EGF_CA	198..232	CDD:238011	13/37 (35%)
		LamG	245..391	CDD:214598	53/145 (37%)
		LamG	426..595	CDD:238058	71/168 (42%)
		EGF_CA	625..658	CDD:238011	19/32 (59%)
		Laminin_G_2	828..955	CDD:280389	61/128 (48%)
		LamG	1019..1197	CDD:238058	64/184 (35%)
		Syndecan	1510..>1549	CDD:279386	11/44 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7806
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D24127at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820