DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-1 and nrxn2a

DIOPT Version :9

Sequence 1:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster
Sequence 2:	NP_001073439.1	Gene:	nrxn2a / 558326	ZFINID:	ZDB-GENE-070206-5	Length:	1670	Species:	Danio rerio

Alignment Length:	1873	Identity:	579/1873 - (30%)
Similarity:	870/1873 - (46%)	Gaps:	388/1873 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 RSYRVLIVSALLVSLAASFVTLSAGFQLDGSQNSFYTFRKWYTGLNGTLELEFKTEQPNGLVLYT 144
            |.:|.:.:|...|.|....::::...:.||....:..:..|..|..|.|....||.....:|||.
Zfish     4 RKWRCVKLSPAFVWLGLVVLSVTTALEFDGLPGQWVRYGPWEAGATGELSFTMKTNISKAIVLYL 68

  Fly   145 DDGGTYDFFELKLVEGALRLRYNLGGGAQIITVGRELH--DGHWHKVQVLRNDEQTSLIVDGVSQ 207
            ||||..||.||.:.:|.|:||:.:..| :..::..|.|  |..||:|.:.||..:|.|::||.|:
Zfish    69 DDGGNCDFLELLINDGRLQLRFAIHCG-EPASLHMETHISDERWHRVLLTRNYRETMLVMDGESK 132

  Fly   208 QRSTKGKEFQFGKFASNSDVYVGGMPNWYSSKLALLALPSVIFEPRFRGAIRNLVYADQPGGSTR 272
            ....|.|.   .:....||:||||:|.  ..:|:.|...:|.:||.|||.|.||...:.......
Zfish   133 VAEVKSKR---REMMVASDLYVGGIPP--DVRLSALTSSTVKYEPPFRGLIANLKLGETAPALLD 192

  Fly   273 RQEIKQQRDIKCGDVPCDHGELPARERPLRGVRGGNTTDACERNDPCQHGGICISTDSGPICECR 337
            .|.:|...|.                             .|.:.:||.:||.|....|..:|:|.
Zfish   193 SQGVKNDLDY-----------------------------LCTKQNPCSNGGRCSIQGSEVLCDCS 228

  Fly   338 NLEYDGQYCE---------------KEKAP--------------------SEATFRGTQFLSYDL 367
            |..|.|:||.               |.:||                    |.|||:|.:|.||||
Zfish   229 NTGYKGKYCTEVLQQVLGGLAHLTLKSQAPGAAPLMATPAAGDPKSGQVESVATFKGNEFFSYDL 293

  Fly   368 GQTGAEPIVSAQDAISFYFRTRQPNGLLFYTGHGTDYLNLALRDGGVSLTMGLANGKQEMHIKPS 432
            .|   :||.|:.|.|:..|||.|.||||.:||...||:||:|:.|.|.|.:.|.:|..|..::||
Zfish   294 SQ---KPIQSSTDEITLSFRTLQRNGLLLHTGKSADYVNLSLKSGAVCLVINLGSGAFEALVEPS 355

  Fly   433 KVRFDDHQWHKVTVHRRIQE-----ISSITSFCRLVTV-VDDVYTDHSHIAGKFTMLSSSR-VYV 490
            ..:|:|:.||.|.|.|.:::     :.::.....:||: ||.:.|...:....:|||.|.. .||
Zfish   356 DGKFNDNAWHAVRVSRNLRQRAGVGLPTVNKLHYMVTISVDGLLTTTGYTQEDYTMLGSDDFFYV 420

  Fly   491 GGAVNPRALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQCPSGDPQDP 555
            ||:.|...|.|:.|..||:|||:.|.::.:...|.|..||:.....:.:.|:|.::|......||
Zfish   421 GGSPNTADLPGSPVSNNFMGCLKDVVYTNNEFRLELSHLAELRDPKVTLHGDLTFRCEDVAALDP 485

  Fly   556 VTFTTRESHLVLPPWETGKQSSISFKFRTKEPNGIIVLATGSKQ------PRAKNPVLIAIELLN 614
            |:|....:::.||.|...|..|:||.|||.||||:::.:.|..|      ||..   ..|:|||:
Zfish   486 VSFDAPTAYVTLPRWNGKKAGSVSFDFRTTEPNGLLLFSHGRPQGSKDHRPRVD---FFAMELLD 547

  Fly   615 GHIYIHLDLGSGASKVRASRRRVDDGDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTILELDGH 679
            |.:::.:|:|||:.|::...::|:||:|..:..:|.||...:||:|....|.|.....||:|||.
Zfish   548 GFLHLLMDMGSGSIKIKVGNKKVNDGEWCHVDFQREGRKGSISVNGRSLPFSTNEGSEILDLDGE 612

  Fly   680 MYLGGVGPAYNSVSWPAAIWTATLRQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSCHVQAN 744
            |||||:......:|.|..:|||.||.|||||:|||.:.|::.|:...|.:|.:..|...|..:.:
Zfish   613 MYLGGLPENSGDLSLPPEVWTARLRLGFVGCVRDLFVDGRSKDLRRLAELQSAPGVSSFCTRETH 677

  Fly   745 -VCNGNPCLNGGTCLEGWNRPICDCSATLYGGPTCGRELATLAFNGSQHMTIWLGNGQGTKTQTE 808
             .|:..||::||.|.|||||.:|||:.|.|.||.|..|.|.|:::||..:.:.:.:  ...::.|
Zfish   678 RRCSSEPCVHGGRCREGWNRHVCDCTGTGYMGPNCEMESAVLSYDGSMFLKVLMPH--AAHSEAE 740

  Fly   809 ELVIRFKTSRPAGLLLLTSAESNSPDRLEIALVAGRVRASVRL------------SDREKNLLAG 861
            ::.:||.:.|..|||:.|::: .|.|.|.:.|..|||:.:|.|            ....:.|.||
Zfish   741 DVSLRFMSQRAYGLLMATTSK-ESADTLRLELDGGRVKLTVNLDCIGIDCNLISTGKGPETLFAG 804

  Fly   862 QSVLNDNNWHTIRFSRRASNLRLQVDGAPPVRGMLSETILGRHSTMEIRSVHLGGLFHAEEEIQM 926
            .. ||||.||:::..||..:|:|.||.. .|.|.:|    |.|:.:|...:..|.:    .|.:.
Zfish   805 HK-LNDNEWHSVKVVRRGKSLQLSVDNV-TVEGQMS----GAHTQLEFHHIETGIM----TERRF 859

  Fly   927 TSTMP-NFVGQMQGLVFNGQRYLDIVKSLGPELSALPSATFKLTARF-----VNSPAGQPYHAAT 985
            .|.|| ||:|.:|||.|||..|||..|:  .::|..     :|.|||     |..|       .:
Zfish   860 ISVMPSNFIGHLQGLSFNGMPYLDQCKN--GDISYC-----ELNARFGMRRIVADP-------VS 910

  Fly   986 FRSKHSYVGLAMLKAYNSISIDFRFKTVEPNGLLVFNGGRRNDFVAVELVNGHIHYTFDLGDGPV 1050
            ||::.|||.|:.|:||.|:.:.|:|||..|:||::||.|..:||:.:|||.|:|||.||||:||.
Zfish   911 FRNRASYVALSTLQAYASMHLFFQFKTTSPDGLILFNSGDGSDFIVIELVKGYIHYVFDLGNGPS 975

  Fly  1051 TMRDKSRIHMNDNRWHQVSIRRPGPKTHTLTVDDSFEIISLTGNNMHLELAGILYIGGVFKDMYS 1115
            .|:..|...:|||:||.|.:.|.....|||.: ||..:...:....:|:|.|.||||||.|.||:
Zfish   976 LMKGNSDKPLNDNQWHNVMVSRDDSNVHTLKI-DSRTVTQHSNGARNLDLKGELYIGGVGKSMYN 1039

  Fly  1116 KLPASISSRSGFEGCLASLDLGDASPSLTSDAVVPSSLVVSGCE-GP-TKCSQNACANRGNCVQQ 1178
            .||..|:||.|::||.||:||......|.:||:.....|..||| || |.|::::|:|:|.|:||
Zfish  1040 SLPKLIASRDGYQGCPASVDLNGRLSDLIADALHRVGQVERGCEAGPGTTCTEDSCSNQGVCLQQ 1104

  Fly  1179 WNAYACECDMTSYTGPTCYDESIAYEFGNNKGMVQYTFPENAQADTEEDNIALGFITTRPDAVLL 1243
            |..:.|:|.||:|.||.|.|....|.||....::.||:..|.:..|..|.:|:||.|.:.||:|:
Zfish  1105 WEGFTCDCTMTTYGGPLCSDPGTTYIFGRGGALITYTWAPNDRPSTRADRLAVGFSTQQSDAILV 1169

  Fly  1244 RVESAT-TQDYMELEIVEGNIFMVYNIGSVDLPLGEIGTKVNDNAYHVVRFQRKGGNATLQLDDY 1307
            :|||:. ..||::|.|.:|.:.:::|:|:.|:.:.|....|||..||||||.|.|||||||:|:.
Zfish  1170 QVESSQGLGDYLQLHIEQGKVGVIFNVGTDDITIDEPAVTVNDGKYHVVRFTRSGGNATLQVDNQ 1234

  Fly  1308 NV------------------------------QALTPQSHHSTVFNTMSNVQVGGKFSRNGRNRI 1342
            .|                              :.|..:....|:||:.:.::|||:..
Zfish  1235 PVIERFPSGNIDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKVGGQDK------- 1292

  Fly  1343 ERPFAGVIAGLSVNKLRILDLAVERDPHITIRGDVQLV---TGVLDRNDLQR-------MQQTLN 1397
            .|||.|.|:||..|.|::|.||.|.||::.:.|:::||   ..||.......       |..|:.
Zfish  1293 GRPFQGQISGLYYNGLQVLKLAAEGDPNVQVAGNLRLVGDAPSVLSTETTSATPPAAADMSTTIM 1357

  Fly  1398 STRQTPAS-------------GYPGALDDLIFSGAGSGCRGDDED--ECTPPFESGSGDDLITPV 1447
            .|..|.|:             ......|||:.  |.:.|..||||  ||.|    |:|.:|:.|:
Zfish  1358 ETTTTMATTTTRRQRSPSLKDSITQNSDDLLV--ASAECPSDDEDLEECEP----GTGGELVLPI 1416

  Fly  1448 Y------------------VPPTKQTTTSQQGNSLSTGGSSSGGVITNGTERAC--DDEDC---- 1488
            .                  .|||..|.......||          |.:.....|  |.|||
Zfish  1417 ITVDTQDPISMATRYPAIPAPPTSLTPLQTTKESL----------ILSDPRPPCPPDQEDCGDPM 1471

  Fly  1489 ---VHGSGDYGETTEQFTSTSTARGSESNNEMVTITTTGRSDVTTEQHQGSSSSSSSGSTPSYAT 1550
               ..|||:..|:.::        ....|:.||
Zfish  1472 EVSAFGSGEMTESDDE--------DFNRNSPMV-------------------------------- 1496

  Fly  1551 TQSSSSSSSGGSAASTPGQVSTTSSVATSSTQRATSSSTSTSSSTTSTTTTTTTTQATPPPEI-- 1613
                                                               |..|...|||.:
Zfish  1497 ---------------------------------------------------TDRTVLPPPPGVGK 1510

  Fly  1614 ------RSTVTERETTPYDIYIAGGGMGGSGRNDHDRMQLP----DEHHP---LPPLPPPIPPQD 1665
                  |..|....|.|..::|..|.|     |..|::.||    ..|.|   .||..|.:|...
Zfish  1511 SGHGDHRPPVPAPTTHPNQLHIPAGKM-----NTRDQVLLPPVPSSRHTPGLTYPPDFPHVPTAH 1570

  Fly  1666 PPPYGPYGGNTYNTNMNNYRPKGKGGRINSIEE--ERTAMIIGIVAGILIAVVLVILLVLWLKSN 1728
            |               .:...||:.|.:..|.|  ..|.|::.|||...:. :|::|..::...|
Zfish  1571 P---------------TDLMEKGRPGAVEVIRESSSTTGMVVDIVAAAALC-ILILLYAMYKYRN 1619

  Fly  1729 GDRG-YKTESEKAAAYGSHNPNA----------ALLGNTSTNGSYHQQRQHHM 1770
            .|.| |:.:..:.:  ||.:..|          |.:..|:|.|...:.:::::
Zfish  1620 RDEGSYQVDQSRNS--GSESNGAVVKEKTPSTTAAVAKTTTKGKKDKDKEYYV 1670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058	55/154 (36%)
		EGF_CA	311..347	CDD:238011	13/35 (37%)
		Laminin_G_2	386..517	CDD:280389	53/137 (39%)
		LamG	555..716	CDD:238058	68/166 (41%)
		EGF	746..777	CDD:278437	17/30 (57%)
		Laminin_G_2	814..945	CDD:280389	49/143 (34%)
		LamG	988..1136	CDD:238058	69/147 (47%)
		EGF	1164..1195	CDD:278437	14/30 (47%)
		Laminin_G_2	1233..1356	CDD:280389	50/153 (33%)
nrxn2a	NP_001073439.1	LamG	28..183	CDD:238058	57/160 (36%)
		EGF	204..236	CDD:278437	12/31 (39%)
		LamG	304..450	CDD:214598	54/145 (37%)
		LamG	485..650	CDD:238058	68/167 (41%)
		EGF_CA	680..713	CDD:238011	18/32 (56%)
		Laminin_G_2	746..879	CDD:280389	49/143 (34%)
		Laminin_G_2	935..1063	CDD:280389	62/128 (48%)
		EGF	1090..>1114	CDD:278437	10/23 (43%)
		LamG	1128..1306	CDD:238058	60/184 (33%)
		Ten_N	<1435..>1569	CDD:284015	41/239 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5005
eggNOG	1	0.900	-	-		E1_KOG3514
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	862	1.000	Inparanoid score	I406
OMA	1	1.010	-	-		QHG46386
OrthoDB	1	1.010	-	-		D24127at33208
OrthoFinder	1	1.000	-	-		FOG0001168
OrthoInspector	1	1.000	-	-		otm24728
orthoMCL	1	0.900	-	-		OOG6_103392
Panther	1	1.100	-	-	O	PTHR15036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X794
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840