DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-1 and nrxn1b

DIOPT Version :9

Sequence 1:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster
Sequence 2:	NP_001277105.1	Gene:	nrxn1b / 555686	ZFINID:	ZDB-GENE-070206-3	Length:	1475	Species:	Danio rerio

Alignment Length:	1449	Identity:	494/1449 - (34%)
Similarity:	746/1449 - (51%)	Gaps:	166/1449 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 LLVSLAASFVTLSAGFQLDGSQNSFYTFRKWYTGLNGTLELEFKTEQPNGLVLYTDDGGTYDFFE 154
            |.:.|........:..:..||...:..|..|.......:....||...|||::|.||.|..||.|
Zfish    16 LFIGLIVCKANAGSSLRFTGSDEQWVAFPMWNACCESEMSFSVKTTHLNGLLVYFDDEGFCDFLE 80

  Fly   155 LKLVEGALRLRYNL-GGGAQIITVGRELHDGHWHKVQVLRNDEQTSLIVDGVSQQRSTKGKEFQF 218
            |.:..|.|||.::: ...:..:.....::|..||.|.::||...|:||||...:....|.:....
Zfish    81 LHVHVGKLRLCFSIFCAESTCVLSDVAINDNRWHSVSIMRNFRNTTLIVDDEVKWEEVKSQRRDM 145

  Fly   219 GKFASNSDVYVGGMPNWYSSKLALLALPSVIFEPRFRGAIRNLVYADQPGGSTRRQEIKQQRDIK 283
            ..|   |.:::||:|:...|....|...:|.....|.|.|                     .|:|
Zfish   146 TVF---SHLFLGGIPSELRSVSLQLTSKTVKDHTSFTGWI---------------------MDVK 186

  Fly   284 CGDVPCDHGELPARERPLRGVRGGNTTDACERNDPCQHGGICISTDSGPICECRNLEYDGQYCEK 348
            ..|           ..|......|...|.|...:.|.:||:|...:..|.|:|....|.|:.|.:
Zfish   187 VND-----------SEPAIISSAGVHEDLCGSENTCLNGGVCSVVEDKPTCDCSQTGYQGKDCSE 240

  Fly   349 --------EKAPSE--ATFRGTQFLSYDLGQTGAEPIVSAQDAISFYFRTRQPNGLLFYTGHGTD 403
                    ::...|  |||||:::..|||   ...||.|:.|.|:..|||.|.|||:.:||...|
Zfish   241 GLAHLMMLDRGMEEYVATFRGSEYFCYDL---SLNPIQSSSDEITLSFRTLQRNGLMLHTGKIAD 302

  Fly   404 YLNLALRDGGVSLTMGLANGKQEMHIKPSKVRFDDHQWHKVTVHRRIQEISSITSFCRLVTVVDD 468
            |:||||::|.|||.:.|.:|..|..::|...:|:|::||.|.|.|.:::.|.: .:..:...||.
Zfish   303 YVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNEWHDVKVLRNLRQHSGV-GYAMVTISVDG 366

  Fly   469 VYTDHSHIAGKFTMLSSSR-VYVGGAVNPRALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKS 532
            :.|...:...::|||.|.. :||||:.:...|..:.|..||:||||:|.:..:...|.|..||..
Zfish   367 ILTTTGYTQEEYTMLGSDDFLYVGGSPSTADLPESPVSNNFMGCLREVVYKNNDAELELSRLAYQ 431

  Fly   533 GSKLIQVAGNLEYQCPSGDPQDPVTFTTRESHLVLPPWETGKQSSISFKFRTKEPNGIIVLATG- 596
            |...:|:.|.:.::|.|....|.:||.|.||.|.||.|...|..||||.|||.||||:::.:.|
Zfish   432 GDPKLQIHGVVAFKCESVATLDAITFETPESFLTLPKWNAKKSGSISFDFRTTEPNGLLLFSCGR 496

  Fly   597 SKQ--PRAKNPVLI-----AIELLNGHIYIHLDLGSGASKVRASRRRVDDGDWHDLILRRNGRDA 654
            :||  ..||:||.:     |||:|:|.:|:.||:|||.:|..|..::|:||:|:.:..:|:|:..
Zfish   497 AKQHNKEAKSPVTLKVDFFAIEMLDGLLYLLLDMGSGTTKTLALNKKVNDGEWYHVDFQRDGKSG 561

  Fly   655 KVSVDGVWNDFRTPGDGTILELDGHMYLGGVGPAYNSVSWPAAIWTATLRQGFVGCLRDLVLSGK 719
            .:|::.|...:..|||..:|:||..:|||||..:.:...:|...|:|.|..|:|||:|||.:.|:
Zfish   562 TISINSVRTPYLCPGDSELLDLDDPLYLGGVPESSSGTVFPTGAWSALLNYGYVGCVRDLFIDGR 626

  Fly   720 AIDIAAFARVQDSASVKPSCHVQ-ANVCNGNPCLNGGTCLEGWNRPICDCSATLYGGPTCGRELA 783
            ::|:...|.:|.:|.|||||..: ...|...||||.|.|.|||:|.||||:.|.:.|.:|.|:..
Zfish   627 SVDVRRAAELQRAAGVKPSCGKEPPGKCVSEPCLNRGVCREGWSRYICDCTGTGFLGHSCERDAT 691

  Fly   784 TLAFNGSQHMTIWLGNGQGTKTQTEELVIRFKTSRPAGLLLLTSAESNSPDRLEIALVAGRVRAS 848
            .|:|:||:.:.:..  .....|:.|::.:||::.|..| :|:.|..:::.|.|.:.|.|||||.:
Zfish   692 ILSFDGSKFLKVQF--SAAMHTEAEDVSLRFRSLRAYG-VLMASTSTHTTDTLRLELEAGRVRLT 753

  Fly   849 VRL---------SDREKNLLAGQSVLNDNNWHTIRFSRRASNLRLQVDGAPPVRGMLSETILGRH 904
            |.|         |...::|.|||: |||:.|||:|..||..:|:|.||..|.|.|    .|.|.|
Zfish   754 VNLDCNRINCTTSKGPESLFAGQN-LNDDEWHTVRVIRRGKSLKLSVDDLPTVDG----EIPGDH 813

  Fly   905 STMEIRSVHLGGLFHAEEEIQMTSTMP-NFVGQMQGLVFNGQRYLDIVKSLGPELSALPSATFKL 968
            :.:|..::.. |:...:.::   .||| ||:|.:|.|:|||:.|:|:.|:...:...
Zfish   814 TQLEFHNIET-GIITGKRQL---PTMPSNFIGHLQSLMFNGKPYIDLCKNGDIDYCQ-------- 866

  Fly   969 TARFVNSPAG------QPYHAATFRSKHSYVGLAMLKAYNSISIDFRFKTVEPNGLLVFNGGRRN 1027
                .|:|.|      .|   .||:|..|||.|..|:||..:.:.|:|||...:||:::|.|..|
Zfish   867 ----TNAPIGFKSIIADP---VTFKSCSSYVTLPSLQAYYYMYLFFQFKTTSADGLILYNSGDGN 924

  Fly  1028 DFVAVELVNGHIHYTFDLGDGPVTMRDKSRIHMNDNRWHQVSIRRPGPKTHTLTVDDSFEIISLT 1092
            ||:|||||.|::||..|||:|...::..|...:|||.||.|.|.|.....||:.:|......:..
Zfish   925 DFIAVELVKGYLHYISDLGNGAHLIKGNSIKPLNDNHWHNVMISRDPNNLHTVRIDTKTTSQTTL 989

  Fly  1093 GNNMHLELAGILYIGGVFKDMYSKLPASISSRSGFEGCLASLDLGDASPSLTSDAVVPSSLVVSG 1157
            |.. :|:|.|.|::|||.:.||..||..:.::.||:|||||:||....|.|.::|:|....:..|
Zfish   990 GAK-NLDLKGDLFVGGVPEQMYKDLPKLVHAKEGFQGCLASVDLNGRLPDLMTEALVCVGQIERG 1053

  Fly  1158 CEGP-TKCSQNACANRGNCVQQWNAYACECDMTSYTGPTCYDESIAYEFGNNKGMVQYTFPENAQ 1221
            |||| :.|.:::|||:|.|:|||..:.|:|.||:|.||.|.|....|.||...|::.|::|.:.:
Zfish  1054 CEGPSSSCEEDSCANQGVCLQQWENFTCDCSMTTYAGPLCADPGSTYVFGRQGGVITYSWPPHDR 1118

  Fly  1222 ADTEEDNIALGFITTRPDAVLLRVE-SATTQDYMELEIVEGNIFMVYNIGSVDLPLGEIGTKVND 1285
            ..|..|.:||||||...||.|:||: ||...||::|.||:||:..|:|:|:.|:.:.|.|..|||
Zfish  1119 PSTRVDRLALGFITLMEDATLVRVDSSAGLGDYLKLHIVKGNVVAVFNVGTYDINIEENGKLVND 1183

  Fly  1286 NAYHVVRFQRKGGNATLQLDDYNVQALTPQSH--------------------------HSTVFNT 1324
            ..||:|||.|.|||||||:||..|....|..|                          ..|:||:
Zfish  1184 GNYHIVRFTRSGGNATLQVDDLPVIERFPPGHIDSHRLGTGRLPYRRLVEESLPKNGRQLTIFNS 1248

  Fly  1325 MSNVQVGG--KFSRNGRNRIERPFAGVIAGLSVNKLRILDLAVERDPHITIRGDVQLVTGVLDRN 1387
            ...:::||  |...:|       |.|.::|...|.|::..:|.:.||::.:.|.|:|| |.|..:
Zfish  1249 QMTIRIGGWQKQQVSG-------FQGQMSGFYYNGLKVFSMAADGDPNVRMEGSVRLV-GELQSS 1305

  Fly  1388 DL----------------QRMQQTLNSTRQTPASGYPGALDDLIFSGAGSGCRGDDEDECTPPFE 1436
            ..                .....|:..|..|||.... ..|:|:.  |.:.|..||||  ..|.|
Zfish  1306 STPHGGATVYQSSVTEISSTTSNTITITYSTPADEQQ-TTDELLV--ASAECPSDDED--IDPCE 1365

  Fly  1437 SGSGDDLITPVYVPPTKQT 1455
            ..||   ....:|||...|
Zfish  1366 PSSG---TLCCFVPPAGPT 1381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058	43/153 (28%)
		EGF_CA	311..347	CDD:238011	11/35 (31%)
		Laminin_G_2	386..517	CDD:280389	51/131 (39%)
		LamG	555..716	CDD:238058	71/168 (42%)
		EGF	746..777	CDD:278437	17/30 (57%)
		Laminin_G_2	814..945	CDD:280389	51/140 (36%)
		LamG	988..1136	CDD:238058	62/147 (42%)
		EGF	1164..1195	CDD:278437	15/30 (50%)
		Laminin_G_2	1233..1356	CDD:280389	54/151 (36%)
nrxn1b	NP_001277105.1	LamG	30..188	CDD:238058	46/181 (25%)
		EGF	207..237	CDD:278437	9/29 (31%)
		LamG	280..419	CDD:214598	52/139 (37%)
		LamG	476..626	CDD:214598	61/149 (41%)
		EGF	654..>676	CDD:278437	13/21 (62%)
		LamG	715..851	CDD:214598	52/145 (36%)
		Laminin_G_2	907..1035	CDD:280389	55/128 (43%)
		Laminin_G_2	1130..1276	CDD:280389	54/152 (36%)
		Syndecan	1403..>1442	CDD:279386
		4.1m	1423..1441	CDD:128590
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5005
eggNOG	1	0.900	-	-		E1_KOG3514
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	862	1.000	Inparanoid score	I406
OMA	1	1.010	-	-		QHG46386
OrthoDB	1	1.010	-	-		D24127at33208
OrthoFinder	1	1.000	-	-		FOG0001168
OrthoInspector	1	1.000	-	-		otm24728
orthoMCL	1	0.900	-	-		OOG6_103392
Panther	1	1.100	-	-	O	PTHR15036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X794
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.880