DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-1 and tld

DIOPT Version :9

Sequence 1:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster
Sequence 2:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster

Alignment Length:	1195	Identity:	228/1195 - (19%)
Similarity:	372/1195 - (31%)	Gaps:	378/1195 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KAPHSATYQDNYADAAMTARTRPSMDMDQ-QRNRNQAELRLLPAQRTSTSAFE------SPDLRF 59
            |.|....||      ..|.|........| .:::|:|.|||.|....:..|.:      ||.|..
  Fly    70 KEPKDDIYQ------LKTTRQHSGRRRKQSHKSQNKAALRLPPPFLWTDDAVDVLQHSHSPTLNG 128

  Fly    60 NKARRRRRSEQVPPVVVEYRRSYRVLIVSALLVSLAASFVTLSAGFQLD----GSQNSFY--TFR 118
            ...:||||:     |.|...|::...::.                :::|    |:..:.:  ..|
  Fly   129 QPIQRRRRA-----VTVRKERTWDYGVIP----------------YEIDTIFSGAHKALFKQAMR 172

  Fly   119 KWYTGLNGTLELEFKTEQPNGLVLYTDDGGTYDFFELKLVEGALRLRYNLGGGAQIITVGRE--- 180
            .|.   |.|. ::|....||   |:.:    |.:|.:|.. |........|.|.|.|::||.
  Fly   173 HWE---NFTC-IKFVERDPN---LHAN----YIYFTVKNC-GCCSFLGKNGNGRQPISIGRNCEK 225

  Fly   181 ----LHD-GH---WHKVQVLRNDEQTSLIVDGVSQQRSTKGKEFQFGKFASNSDVYVGGMPNWYS 237
                :|: ||   :|. :..|.|....::   :::....:|:|:.|       ||.   .|....
  Fly   226 FGIIIHELGHTIGFHH-EHARGDRDKHIV---INKGNIMRGQEYNF-------DVL---SPEEVD 276

  Fly   238 SKLALLALPSVIFEPRFRGAIRNLVYAD--QPGGSTRRQEIKQQRDIKCGDVPCDHGELPARERP 300
            ..|....|.|::...  :.:.....|.|  .|                .|..|..|.||..|:|.
  Fly   277 LPLLPYDLNSIMHYA--KNSFSKSPYLDTITP----------------IGIPPGTHLELGQRKRL 323

  Fly   301 LRG-VRGGNTTDACERNDPC-----QHGGICIS-----TDSGPICECRNLEYDGQYCEKEKAPSE 354
            .|| :...|....|.   .|     |:.|..:|     :.:|.:.|   .|..|...|...|.||
  Fly   324 SRGDIVQANLLYKCA---SCGRTYQQNSGHIVSPHFIYSGNGVLSE---FEGSGDAGEDPSAESE 382

  Fly   355 ATFRGTQFLSYDLGQTGAEPIVSAQDAISFYFRTRQPNGLLFYTGHGTDYLNLALRDGGVSLTMG 419
                      :|...|..|..::|.:........:|.: |:.......|||.  :|||
  Fly   383 ----------FDASLTNCEWRITATNGEKVILHLQQLH-LMSSDDCTQDYLE--IRDG------- 427

  Fly   420 LANGKQEMHIKPSKVRFDDHQWHKVTVHRRIQEISSITSFCRLVTVVDDVYTDHSHIAGKFTMLS 484
                                .|||..:.|||         |             .:::|:.....
  Fly   428 --------------------YWHKSPLVRRI---------C-------------GNVSGEVITTQ 450

  Fly   485 SSRVYVGGAVNPRALLGAR-VHTNF-VGCLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQC 547
            :||:.: ..||..|..|.| ....| |.|...::.:.|    ..||
  Fly   451 TSRMLL-NYVNRNAAKGYRGFKARFEVVCGGDLKLTKD----QSID------------------- 491

  Fly   548 PSGDPQDPVTF----------TTRESH---LVLPPWETGKQSSISFKF-RTKEPN----GIIVLA 594
               .|..|:.:          |..::|   |....:|..|....::.| ..::.|    .:|...
  Fly   492 ---SPNYPMDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIGRF 553

  Fly   595 TGSKQPRAKNPVLIAIELLNGHIYIHLDLGSGASKVRASR---------RRVDDGDWHDLI---- 646
            .|.|.|.       .|:..:..:||.....|...|:..|.         :..|.|..|..|
  Fly   554 CGDKLPP-------NIKTRSNQMYIRFVSDSSVQKLGFSAALMLDVDECKFTDHGCQHLCINTLG 611

  Fly   647 -----------LRRNGRDAKVSVDG--------------------------VWNDFRTPGDGTIL 674
                       |:.||:..:.:..|                          ||.....|.....|
  Fly   612 SYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFL 676

  Fly   675 ELDGHMYLGGVGPAYNSVSWPAAIWTATLRQG-----FVGC---LRDLVLSGKAIDIAAFARVQD 731
            .. .|..|.|....|...::...|..:.:|..     .:.|   |..:|.|.::|....|   ..
  Fly   677 NF-SHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGIYCGHELPPVVNSEQSILRLEF---YS 737

  Fly   732 SASVKPSCHVQANVCNGNPC-LNGGTCLEGWNRPICDCSATLYGGPTCG-RELATLAFNGSQHMT 794
            ..:|:.|..|...|.:.:.| :|.|.|..       .|..| :|...|. |...|||.||.
  Fly   738 DRTVQRSGFVAKFVIDVDECSMNNGGCQH-------RCRNT-FGSYQCSCRNGYTLAENGH---- 790

  Fly   795 IWLGNGQGTKTQTEELVIRFKTSRPAGLLLLTSAESNSPDRL----EIALVAGRVRASVRLSDRE 855
                    ..|:|.   .:|:.:...|:|...:...:.|..:    ....|.|.   .::|:..:
  Fly   791 --------NCTETR---CKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGH---RIQLTFHD 841

  Fly   856 KNLLAGQSVLNDNNWHTIRFSRRASN---LRLQVDGAPPVRGMLSET----ILGRHSTMEIRSV- 912
            ..:.:.|..:.|   :...:..|:.|   |.:...|..|...:.|..    :|...:.::.:..
  Fly   842 FEVESHQECIYD---YVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRKGFK 903

  Fly   913 -----HLGGLFHAEEEIQMTSTMPNFVGQMQGLVFNGQRYLDIVKSLGPELSALPSATFKLTARF 972
                 ..||...|....|...:.|.:..:    .:....|.|.      .:.|.|.::.|:  ||
  Fly   904 ATFVSECGGYLRATNHSQTFYSHPRYGSR----PYKRNMYCDW------RIQADPESSVKI--RF 956

  Fly   973 VN--------------SPAGQPYHAAT----FRSKHSYVGLAMLKAYNSISIDFRFKTVEPNGLL 1019
            ::              ....:.|...|    |..||.    ..:...||.::..||:|.|.|.|
  Fly   957 LHFEIEYSERCDYDYLEITEEGYSMNTIHGRFCGKHK----PPIIISNSDTLLLRFQTDESNSL- 1016

  Fly  1020 VFNGGRRNDFVAVELVNGHIHYTFD 1044
               .|....|:||:.....:...||
  Fly  1017 ---RGFAISFMAVDPPEDSVGEDFD 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058	33/165 (20%)
		EGF_CA	311..347	CDD:238011	9/45 (20%)
		Laminin_G_2	386..517	CDD:280389	26/132 (20%)
		LamG	555..716	CDD:238058	38/236 (16%)
		EGF	746..777	CDD:278437	7/31 (23%)
		Laminin_G_2	814..945	CDD:280389	21/147 (14%)
		LamG	988..1136	CDD:238058	16/57 (28%)
		EGF	1164..1195	CDD:278437
		Laminin_G_2	1233..1356	CDD:280389
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	51/265 (19%)
		Astacin	144..339	CDD:279708	50/257 (19%)
		CUB	388..474	CDD:214483	26/138 (19%)
		CUB	478..586	CDD:278839	22/140 (16%)
		FXa_inhibition	595..630	CDD:291342	7/34 (21%)
		CUB	634..750	CDD:278839	20/119 (17%)
		FXa_inhibition	757..792	CDD:291342	14/54 (26%)
		CUB	797..906	CDD:278839	16/114 (14%)
		CUB	910..1023	CDD:278839	26/132 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444945
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930