DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrx-1 and LanB1

DIOPT Version :9

Sequence 1:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster
Sequence 2:	NP_476618.1	Gene:	LanB1 / 34068	FlyBaseID:	FBgn0261800	Length:	1788	Species:	Drosophila melanogaster

Alignment Length:	365	Identity:	77/365 - (21%)
Similarity:	120/365 - (32%)	Gaps:	115/365 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1154 VVSGCEGPTKCSQNACANRGNCVQQWNAYA--CECDMTSYTGPTCYDESIAYEFGNNKGMVQYTF 1216
            :.|| ||...|:   |...|...:|.|:|.  |:| ...:.|..| ::..|:.:||.....|
  Fly  1085 IASG-EGCESCN---CDPIGALHEQCNSYTGQCQC-KPGFGGRAC-NQCQAHYWGNPNEKCQ--- 1140

  Fly  1217 P--------ENAQADTEEDN--------------IALGFITTRP------------DAVLLRVES 1247
            |        .:.|.|.|..|              .|.|:|...|            |.:|..:|.
  Fly  1141 PCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPCGECFNNWDLILSALED 1205

  Fly  1248 ATTQDYMELEIVEGNIFMVYNIGSVDLPLGEIGTKVNDNAYHVVRFQRKGGNATLQLD--DYNVQ 1310
            |||...:..:    .|..|...|:......|:..|:.    |:....:....:.:.::  ||..|
  Fly  1206 ATTATILRAK----EIKQVGATGAYTSEFSELDKKLQ----HIRNLLQNTSVSLVDIEKLDYETQ 1262

  Fly  1311 ALTP--QSHHSTVFNTMSNV-------------------------QVGGKFSRNG---------- 1338
            :|..  |:.|..:..|..|:                         |:..:...||
  Fly  1263 SLRDQLQASHGRLSETEQNLDDIYNSLSLSGVELESLQNHSRLVQQLSKELKENGIQLQESNIEG 1327

  Fly  1339 -----RNRIERPFAGVIAGLSVNKLRILDLAVERDPHI----TIRGDVQLVTGVLDRND--LQRM 1392
                 |:..||     ::.||..|....:||...|.:.    .:...:|.....|..|:  ::..
  Fly  1328 ALNLTRHAYER-----VSNLSTLKDEANELASNTDRNCKRVENLSNKIQAEADDLANNNKLIEDY 1387

  Fly  1393 QQTLNS-TRQTP-----ASGYPGALDDLIFSGAGSG-CRG 1425
            :..|.| |.|.|     ..|.||...|.:..|||.| |.|
  Fly  1388 RAELTSLTSQIPELNNQVCGKPGDPCDSLCGGAGCGHCGG 1427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058
		EGF_CA	311..347	CDD:238011
		Laminin_G_2	386..517	CDD:280389
		LamG	555..716	CDD:238058
		EGF	746..777	CDD:278437
		Laminin_G_2	814..945	CDD:280389
		LamG	988..1136	CDD:238058
		EGF	1164..1195	CDD:278437	9/32 (28%)
		Laminin_G_2	1233..1356	CDD:280389	30/178 (17%)
LanB1	NP_476618.1	Laminin_N	63..286	CDD:278484
		EGF_Lam	287..343	CDD:238012
		Laminin_EGF	355..415	CDD:278482
		Laminin_EGF	418..475	CDD:278482
		EGF_Lam	477..526	CDD:238012
		EGF_Lam	529..567	CDD:214543
		EGF_Lam	789..834	CDD:214543
		Laminin_EGF	837..885	CDD:278482
		Laminin_EGF	883..930	CDD:278482
		Laminin_EGF	933..988	CDD:278482
		Laminin_EGF	991..1043	CDD:278482
		Laminin_EGF	1043..1091	CDD:278482	3/6 (50%)
		Laminin_EGF	1094..1142	CDD:278482	14/55 (25%)
		Laminin_EGF	1142..1190	CDD:278482	8/47 (17%)
		COG6	1212..>1398	CDD:303003	32/198 (16%)
		TelA	1439..1782	CDD:226371
		ApoLp-III_like	1545..1702	CDD:304399
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910