DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nrx-1 and HSPG2

DIOPT Version :9

Sequence 1:NP_001262840.1 Gene:Nrx-1 / 42646 FlyBaseID:FBgn0038975 Length:1847 Species:Drosophila melanogaster
Sequence 2:XP_011539620.1 Gene:HSPG2 / 3339 HGNCID:5273 Length:4574 Species:Homo sapiens


Alignment Length:1519 Identity:301/1519 - (19%)
Similarity:480/1519 - (31%) Gaps:570/1519 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 NKARRRRRSEQVPPVVVEYRR-----SYRVLIVSALLVSLAASFVTLSAGFQLDGSQNSFYTFRK 119
            :.||..|.|.  .|..:|.|.     |:.||.:|:...|.|.::|.|        :||:..|.:|
Human  3325 SSARWTRISS--TPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCL--------AQNALGTAQK 3379

  Fly   120 WY-----TGLNGTLELEFKTEQPNGLVLYTDDGGTYDFFELKLVEGALRLRYNLGGGAQIITVGR 179
            ..     ||.......:.:.|:..   |..:.|.|          ..||..   ..|:...|:  
Human  3380 QVEVIVDTGAMAPGAPQVQAEEAE---LTVEAGHT----------ATLRCS---ATGSPAPTI-- 3426

  Fly   180 ELHDGHWHKVQVLRND-------EQTSLIVDGVSQQRSTKGKEFQFGKFASN------------- 224
                 ||.|   ||:.       |..:||:..|:||.|        |::..|             
Human  3427 -----HWSK---LRSPLPWQHRLEGDTLIIPRVAQQDS--------GQYICNATSPAGHAEATII 3475

  Fly   225 ----SDVYVGGMPNWYS------SKLALLA--LPSVIFE-------------------------- 251
                |..|...:|...|      .:|..||  .|.:.|:                          
Human  3476 LHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAP 3540

  Fly   252 ---PRFRGAIRNLVYADQ-------------------PGGSTRRQEIKQQRDIK---------CG 285
               .|:|..:.|.|.:.:                   |.|||...::..|.:.|         |.
Human  3541 EDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCA 3605

  Fly   286 DVPCDH----------GELPARERPLRGVRGG-----NTTDACERNDPCQ-HGGICISTDSGPIC 334
             ||.|.          |:||    |...|:.|     |...:|:....|| ||            
Human  3606 -VPSDRGTQLRWFKEGGQLP----PGHSVQDGVLRIQNLDQSCQGTYICQAHG------------ 3653

  Fly   335 ECRNLEYDGQYCEKEKAPSEATFRGTQFLSYDLGQTGAEPIVSAQDAISFYFRTRQPNGLLFYTG 399
                                         .:...|..|:.::.|..::....||.....::   |
Human  3654 -----------------------------PWGKAQASAQLVIQALPSVLINIRTSVQTVVV---G 3686

  Fly   400 HGTDYLNLALRDGGVSLTMGLANGKQEMHIKPSKVRFDDHQWHKVTVHRRIQEISSITSFCRLVT 464
            |..::..|||.|....:|.....|    |::|..|     |...|.   ||..:....:.....|
Human  3687 HAVEFECLALGDPKPQVTWSKVGG----HLRPGIV-----QSGGVV---RIAHVELADAGQYRCT 3739

  Fly   465 VVDDVYTDHSHI------AGKFTMLSSSRVYVG-GAVNPRALLGARVHTNFVGCLRKVEFSADTL 522
            ..:...|..||:      ..:.:|....||..| .||.|....|               :....:
Human  3740 ATNAAGTTQSHVLLLVQALPQISMPQEVRVPAGSAAVFPCIASG---------------YPTPDI 3789

  Fly   523 NLNLIDLAKSGSKLIQVAGNLEYQCPSGDPQDPVTF----TTRE------SHLVLP--------- 568
            :.:.:|.:......::   |.....||..|||..|:    |.|:      :||.:|         
Human  3790 SWSKLDGSLPPDSRLE---NNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERVVPYFTQ 3851

  Fly   569 ------PWETGKQS----SISFKFRTKEPNGIIVLATGSKQPRA------KNPVLIAIELLNGHI 617
                  |..|.|.:    .|...||....:|:::.....:.|.:      :.|..|:..|:.|..
Human  3852 TPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDFISFGLVGGRP 3916

  Fly   618 YIHLDLGSGASKVRASRRRVDDGDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTI------LEL 676
            ....|.|||.:.:| ....:..|.:|.:.|.|:.....:.|..:     .|.:||.      |:|
Human  3917 EFRFDAGSGMATIR-HPTPLALGHFHTVTLLRSLTQGSLIVGDL-----APVNGTSQGKFQGLDL 3975

  Fly   677 DGHMYLGGVGPAYNSVSWPAAIWTATLRQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSCHV 741
            :..:||||. |.|      .||..|.|..||:||:|:|.:.|:.|   .|..:..:|.....|  
Human  3976 NEELYLGGY-PDY------GAIPKAGLSSGFIGCVRELRIQGEEI---VFHDLNLTAHGISHC-- 4028

  Fly   742 QANVCNGNPCLNGGTCLEGWNRP-ICDCSATLYGGPTCGRELATLAFNGSQHMTIWLGNGQGTKT 805
              ..|...||.|||.|.:..:.. :|.|.|               .|.||               
Human  4029 --PTCRDRPCQNGGQCHDSESSSYVCVCPA---------------GFTGS--------------- 4061

  Fly   806 QTEELVIRFKTSRPAGLLLLTSAESNSPDRLEIALVAGRVRASVRLSDREKNLLAGQSVLNDNNW 870
                   |.:.|:    .|....|:..||    |....|                          
Human  4062 -------RCEHSQ----ALHCHPEACGPD----ATCVNR-------------------------- 4085

  Fly   871 HTIRFSRRASNLRLQVDGAPPVRGMLSETILGRHSTMEIRSVHLGGLFHAEEEIQMTSTMPNFVG 935
                               |..||......|||           .|| ..||.:.:|:       
Human  4086 -------------------PDGRGYTCRCHLGR-----------SGL-RCEEGVTVTT------- 4112

  Fly   936 QMQGLVFNGQRYLDIVKSLGPELSALPSATFKLTARFVNSPAGQPYHAATFRSKHSYVGL-AMLK 999
                                |.||.                ||            ||:.| |:..
Human  4113 --------------------PSLSG----------------AG------------SYLALPALTN 4129

  Fly  1000 AYNSISIDFRFKTVEPNGLLVFNGGRR---NDFVAVELVNGHIHYTFDLGDGPVTMRDKSRIHMN 1061
            .::.:.:|..||.:.|:|:|:|:||:.   .|||::.:|.||:.:.::||.|...:|....:.: 
Human  4130 THHELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLAL- 4193

  Fly  1062 DNRWHQVSIRRPGPKTHTLTVDDSFEII-SLTGNNMHLELAGILYIGGVFKDMYSKLPASISSRS 1125
             .|||:||..|.. |..:|.|:....:: |..|.:..|.|..:||:|||...:  .|..:.:..:
Human  4194 -GRWHRVSAERLN-KDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSV--PLSPATNMSA 4254

  Fly  1126 GFEGCLASLDLGDASPSLTSDAVVPSSLVVSGCEGPTKCSQNACANRGNCVQQWN-AYACECD-- 1187
            .|.||:..:.:......||...:  .|..:..|...:.|.:..|.:...|:.... .:.|.|.  
Human  4255 HFRGCVGEVSVNGKRLDLTYSFL--GSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCLCRDG 4317

  Fly  1188 --------------------------------MTSYTGPTCYDES---IAYE------FGNNKGM 1211
                                            :..::||.|...|   ||..      .|.|...
Human  4318 FKGDLCEHEENPCQLREPCLHGGTCQGTRCLCLPGFSGPRCQQGSGHGIAESDWHLEGSGGNDAP 4382

  Fly  1212 VQY----------TFPENAQADTEEDNIALGFITTR-----PDAVLLRVESATT----------- 1250
            .||          .||              |.:.:|     |:.:.|.|.::|.           
Human  4383 GQYGAYFHDDGFLAFP--------------GHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEV 4433

  Fly  1251 ------QDYMELEIVEGNIFMVYNIGSVDLPLGEIGTKVNDNAYHVVRFQRKGGNATLQLD-DYN 1308
                  :|::.|.:.:|::...|.:||.:..|.. ...:||..:|.|...|:|...::|:| :..
Human  4434 GEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVS-EDPINDGEWHRVTALREGRRGSIQVDGEEL 4497

  Fly  1309 VQALTPQSHHSTVFNTMSNVQVGG 1332
            |...:|..  :...|...:|.:||
Human  4498 VSGRSPGP--NVAVNAKGSVYIGG 4519

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nrx-1NP_001262840.1 LamG 110..263 CDD:238058 40/218 (18%)
EGF_CA 311..347 CDD:238011 5/36 (14%)
Laminin_G_2 386..517 CDD:280389 29/137 (21%)
LamG 555..716 CDD:238058 49/201 (24%)
EGF 746..777 CDD:278437 10/31 (32%)
Laminin_G_2 814..945 CDD:280389 18/130 (14%)
LamG 988..1136 CDD:238058 45/152 (30%)
EGF 1164..1195 CDD:278437 6/65 (9%)
Laminin_G_2 1233..1356 CDD:280389 26/123 (21%)
HSPG2XP_011539620.1 SEA 80..193 CDD:214554
LDLa 216..251 CDD:238060
LDLa 302..336 CDD:238060
LDLa 342..376 CDD:238060
LDLa 385..420 CDD:238060
IG 431..507 CDD:214652
Ig_Perlecan_D2_like 438..515 CDD:143220
LamB 608..734 CDD:214597
EGF_Lam 782..824 CDD:238012
EGF_Lam 831..888 CDD:238012
Laminin_EGF 897..939 CDD:278482
LamB 1003..1130 CDD:214597
EGF_Lam 1176..1225 CDD:238012
EGF_Lam 1227..1282 CDD:238012
Laminin_EGF 1293..1340 CDD:278482
LamB 1574..1699 CDD:214597
EGF_Lam 1746..1794 CDD:238012
Laminin_EGF 1796..1851 CDD:278482
Ig_2 1866..1958 CDD:290606
IG_like 1866..1946 CDD:214653
Ig3_Perlecan_like 1954..2039 CDD:143231
IG 1961..2040 CDD:214652
I-set 2049..2133 CDD:254352
Ig 2063..2133 CDD:299845
I-set 2139..2225 CDD:254352
IGc2 2153..2215 CDD:197706
IG_like 2240..2317 CDD:214653
IGc2 2247..2307 CDD:197706
IG 2341..2418 CDD:214652
IGc2 2348..2408 CDD:197706
IG_like 2434..2508 CDD:214653
IGc2 2441..2500 CDD:197706
IG_like 2530..2607 CDD:214653
IGc2 2537..2595 CDD:197706
I-set 2620..2703 CDD:254352
IGc2 2633..2693 CDD:197706
IG 2731..2800 CDD:214652
IGc2 2731..2790 CDD:197706
IG_like 2819..2896 CDD:214653
IGc2 2826..2885 CDD:197706
IG 2916..2993 CDD:214652
IGc2 2923..2983 CDD:197706
IG 3016..3093 CDD:214652
IGc2 3023..3083 CDD:197706
Ig_2 3112..3192 CDD:290606
IG_like 3115..3192 CDD:214653
I-set 3205..3291 CDD:254352
ig 3209..3289 CDD:278476
IG 3303..3385 CDD:214652 19/69 (28%)
Ig 3313..3382 CDD:143165 19/66 (29%)
IG 3404..3478 CDD:214652 21/104 (20%)
IGc2 3409..3468 CDD:197706 20/89 (22%)
I-set 3482..3565 CDD:254352 12/82 (15%)
IGc2 3496..3555 CDD:197706 8/58 (14%)
IG_like 3589..3666 CDD:214653 20/122 (16%)
Ig 3600..3666 CDD:299845 18/111 (16%)
I-set 3676..3755 CDD:254352 21/93 (23%)
IGc2 3686..3745 CDD:197706 16/70 (23%)
I-set 3764..3841 CDD:254352 19/94 (20%)
Ig 3779..3834 CDD:299845 11/72 (15%)
LamG 3848..4008 CDD:238058 43/172 (25%)
EGF_CA <4035..4064 CDD:238011 13/65 (20%)
LamG 4117..4266 CDD:238058 47/181 (26%)
EGF 4291..4321 CDD:278437 5/29 (17%)
EGF_CA 4328..4359 CDD:238011 2/30 (7%)
LamG 4386..4545 CDD:238058 29/151 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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