DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-1 and Cntnap4

DIOPT Version :9

Sequence 1:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster
Sequence 2:	NP_001100902.1	Gene:	Cntnap4 / 307865	RGDID:	1306459	Length:	1310	Species:	Rattus norvegicus

Alignment Length:	1133	Identity:	262/1133 - (23%)
Similarity:	447/1133 - (39%)	Gaps:	237/1133 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   359 GTQFLSYDLGQTGAEPIVSAQDAISFYFRTRQPNGLLFY-TGHGTDYLNLALRDGGVSLTMGLAN 422
            |...|.|...|....||   :|.||..|:|.:.:|:|.: .|.|.|::.|.||.|.:.|.:....
  Rat   190 GKSSLLYRFDQNSLSPI---RDIISLKFKTMESDGILLHRAGPGGDHITLELRRGKLFLLIHSGE 251

  Fly   423 GKQEMHIKPSKVR----FDDHQWHKVTVHRRIQEISSITSFCRLVTVVDDVYTDHSHIAGKFTML 483
            .:.....:|..:.    .||..||.|.:.|..::::        .||  |.:..|.|..|:|..|
  Rat   252 ARLTSSSRPINLTLGSLLDDQHWHSVLIQRLGKQVN--------FTV--DEHRRHFHAQGEFNYL 306

  Fly   484 SSSRVYVGGAVNPRALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQCP 548
            ........|.::..|...:..:..|.|||..:.::    .:::|.|||..|..|...||..:.|
  Rat   307 DLDYEISFGGISAPAKSVSLPYKYFRGCLENLFYN----GVDVIGLAKQHSPQIITMGNTSFSC- 366

  Fly   549 SGDPQD-PVTFTTRESHLVLPPWETGKQSSISFKFRTKEPNGIIV-----LATGSKQPRAKNPVL 607
             ..||. |:||.:..|:||||.....:..|:||:|||....|:::     |.:||
  Rat   367 -SQPQSMPLTFLSTRSYLVLPASSKEEAISVSFQFRTWNKAGLLLFSELWLMSGS---------- 420

  Fly   608 IAIELLNGHIYIHL--------DLGSGASKVRASRRRVDDGDWHDLILRRNGRDAKVSVDG---- 660
            :.:.|.:|.:.::|        |:.:||.        :|||.||.:.|........|.|||
  Rat   421 LLLSLSDGRLKLNLHQPGKSPSDITAGAG--------LDDGQWHSVSLSAKRNHLTVVVDGHISP 477

  Fly   661 --VWNDFRTPGDGTILELDGHMYLGGVGPAYNSVSWPAAIWTATLRQ---GFVGCLRDLVLSGKA 720
              .|........|      |..|.||.         |...:.:..:.   ||.||:|.:.:..|.
  Rat   478 ASPWLGPEQVNSG------GIFYFGGC---------PDKSFGSRCKSPLGGFQGCMRLISIQDKM 527

  Fly   721 IDIAA--------FARVQ-DSASVKPSCHVQANVCNGNPCLNGGTCLEGWNRPICDCSATLYGGP 776
            :|:.|        |:.:| ||..:       ::.|..|.|.:||.|.:.|:...|:|:.|.|.|.
  Rat   528 VDLLAVQQGSLGNFSDLQIDSCGI-------SDRCLPNSCEHGGECSQSWSTFHCNCTNTGYTGA 585

  Fly   777 TCGRELATLAFNGSQHMTIWLGNGQG-------------------TKTQTEELVIRFKTSRPAGL 822
            ||...:...:....:|.    ||..|                   ..|:|...||....|   .|
  Rat   586 TCHSSVYEQSCEAYKHR----GNASGFYYIDSDGSGPLRPFLLYCNMTETAWTVIHHNGS---DL 643

  Fly   823 LLLTSAESNSPDR--LEIALVAGRVRASVRLSDR---------EKNLLAGQSVLNDNNWHTIRFS 876
            :.:.:|.|.:...  .|.....|:::||:..::.         :|:.|..|...:..:|    :.
  Rat   644 MRVRNAHSENVHTGVFEYVASMGQLQASINRAEHCQQELVYYCKKSRLVNQQDGSPRSW----WV 704

  Fly   877 RRASNLRLQVDGAPPVRGMLSETILGRHSTMEIRSVHLG------------GLFHAEEEIQMTST 929
            .|.:..:....|:.|   |..:...|..........|..            |....:|.:.:|..
  Rat   705 GRTNETQTYWGGSLP---MPQKCTCGLEGNCIDAQYHCNCDADRNEWTNDTGFLSYKEHLPVTKI 766

  Fly   930 MPNFVGQMQGLVFNGQRYLDIVKSLGPELSALPSATFKLTARFVNSPAGQPY-HAATFRSKHSYV 993
            :         :...|:.:.:....|||.|..                ..:|: :||:|.::.||:
  Rat   767 V---------ITDTGRPHSEAAYKLGPLLCR----------------GDRPFWNAASFNTEASYL 806

  Fly   994 GLAMLKAYNSISIDFRFKTVEPNGLLVFNGGRRNDFVAVELVN-GHIHYTFDLGDGPVTMRDKSR 1057
            .........|..:.|.|||...:|:.:.|.| ..||:.:||.: ..:.::||:|:||..:...|.
  Rat   807 HFPTFHGELSADVSFYFKTTALSGVFLENLG-ITDFIRIELRSPTTVTFSFDVGNGPFELSVHSP 870

  Fly  1058 IHMNDNRWHQVSIRRPGPKTHTLTVDDSFEIISLTGNNMH--LELAGILYIGGVFKDMYSKLPAS 1120
            .|.|||:||.|.:.| ..|..:|.||:....|.....:.|  |:|...|::||           :
  Rat   871 THFNDNQWHHVRVER-NTKEASLQVDELPPKIQAAPTDGHVLLQLNSQLFVGG-----------T 923

  Fly  1121 ISSRSGFEGCLASLDLGDASPSLTSDAVVPSSLVVSGCEGPTKCSQNACANRGNCVQQWNAYACE 1185
            .:.:.||.||:.||.|...:..|...|.|... |..||.|........|.:.|.|.::.:.:.|:
  Rat   924 ATRQRGFLGCIRSLQLNGMALDLEERATVTPG-VQPGCRGHCGSYGKLCRHGGKCREKPSGFFCD 987

  Fly  1186 CDMTSYTGPTCYDESIAYEFGNNKGMVQYTFPENAQADTE---------------EDNIALGFIT 1235
            |..::|.||.|..|..|| ||:...:: |.|.||......               .:.:...|.|
  Rat   988 CSSSAYAGPFCSKEISAY-FGSGSSVI-YNFQENYSLSKNSSFHAASFHGDMKLGRETVKFNFRT 1050

  Fly  1236 TRPDAVLLRVESATTQDYMELEIVE-GNIFMVYNIG--------SVDLPLGEIGTKVNDNAYHVV 1291
            ||..::||.: |:..::|:.:.|.: |::.:.|.:.        |.||      ..:.|...|.:
  Rat  1051 TRAPSLLLYM-SSFYKEYLSVIIAKNGSLQIRYRLNKYHEPDVISFDL------KSMADGQLHHL 1108

  Fly  1292 RFQRKGGNATLQLDDYNVQALTPQSHHSTVFNTMSNVQVGGKFSRNGRNR-----IERPFAGVIA 1351
            :..|:.|...:::|: |.:..|..| ..|.|:.:.::.:|.....:..::     ....|.|.::
  Rat  1109 KISREEGMVFVEIDE-NTRRQTYLS-SGTEFSAVKSLVLGRMLEYSDVDQETALAAAHGFTGCLS 1171

  Fly  1352 GLSVNKLRILDLAVE--RDPHITIRGDV 1377
            .:..:.:..|..|::  |...:|:.|.|
  Rat  1172 AVQFSHIAPLKAALQPGRPAPVTVTGHV 1199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058
		EGF_CA	311..347	CDD:238011
		Laminin_G_2	386..517	CDD:280389	33/135 (24%)
		LamG	555..716	CDD:238058	46/182 (25%)
		EGF	746..777	CDD:278437	12/30 (40%)
		Laminin_G_2	814..945	CDD:280389	21/153 (14%)
		LamG	988..1136	CDD:238058	45/150 (30%)
		EGF	1164..1195	CDD:278437	7/30 (23%)
		Laminin_G_2	1233..1356	CDD:280389	27/136 (20%)
Cntnap4	NP_001100902.1	FA58C	56..178	CDD:238014
		FA58C	57..179	CDD:214572
		LamG	210..343	CDD:214598	35/146 (24%)
		Laminin_G_2	400..526	CDD:280389	35/158 (22%)
		EGF	555..586	CDD:278437	12/30 (40%)
		FReD	597..>645	CDD:294064	10/54 (19%)
		LamG	796..940	CDD:238058	48/156 (31%)
		Laminin_G_2	1048..1178	CDD:280389	27/138 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910