Protein Alignment Nrx-1 and GAS6

DIOPT Version :9

• Sequence 1: NP_001262840.1
• Gene: Nrx-1 / 42646
• FlyBaseID: FBgn0038975
• Length: 1847
• Species: Drosophila melanogaster
• Sequence 2: NP_000811.1
• Gene: GAS6 / 2621
• HGNCID: 4168
• Length: 678
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 116/541 - (21%)
• Similarity: 193/541 - (35%)
• Gaps: 134/541 - (24%)

  Fly   274 QEIKQQRDIK-CGDVPCDHGELPARERPL--RGVRGGNTTDACERNDPCQHG---GICISTDSGP 332
            |:|.:..|.: ||:..|.:  ||.....|  .|....:...||...|.|..|   .:|:::....
Human   196 QDIDECADSEACGEARCKN--LPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSY 258

  Fly   333 ICEC-----RNLEYDGQYCEK-------EKAPS-EATFRGTQFLSYDLGQTGAEPIVSAQDAISF 384
            .|.|     ..|..|...||.       ..|.| ::.:.|..|....:.:...:.:...:....|
Human   259 TCHCDGRGGLKLSQDMDTCEDILPCVPFSVAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLVAEF 323

  Fly   385 YFRTRQPNGLLFYTGHGTD--YLNLALRDGGVSLTMGLANGKQEMHIKPSKVRFDDHQWHKVTVH 447
            .|||..|.|:|.:.|...|  ::.||||.|.:.|.:.. ||..  .:..|....:...|..::|
Human   324 DFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRY-NGVG--RVTSSGPVINHGMWQTISV- 384

  Fly   448 RRIQEISSITSFCRLVTVVDDVYTDHSHIAGKFTM----LSSSRVYVGG----------AVNPRA 498
               :|::.     .||..|:........:||....    |....:.|||          .:|||
Human   385 ---EELAR-----NLVIKVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPR- 440

  Fly   499 LLGARVHTNFVGCLRKVEF-------SADTLNLN----LIDLAKSGSKLIQVAG----NLEYQCP 548
                     ..||:|...:       ..:|:.:|    ...:.:.|| ....:|    :|:|.
Human   441 ---------LDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGS-FYPGSGFAFYSLDYM-- 493

  Fly   549 SGDPQDPVTFTTRESHLVL---PPWETGKQSSISFKFRTKEPNGIIVLATGSKQPRAKNPVLIAI 610
             ..|.|..|.:|.|..:|.   |..:||...::........|..:.::...|.:...|..|::|:
Human   494 -RTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALVDYHSTKKLKKQLVVLAV 557

  Fly   611 ELLNGHIYIHLDLGSGASKVRASRRRVDDGDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTI-- 673
            |    |..:.|           ...:|.||..|.:.:.....:|.:.|||      |.|...:
Human   558 E----HTALAL-----------MEIKVCDGQEHVVTVSLRDGEATLEVDG------TRGQSEVSA 601

  Fly   674 -------LELDGHM------YLGGVGPAYNSVSWPAAIWTATLRQGFVGCLRDLVLSGKAIDIAA 725
                   ..|:.|:      :.||: |.....|.|.   ||..|    ||: .|.::.:.:|:
Human   602 AQLQERLAVLERHLRSPVLTFAGGL-PDVPVTSAPV---TAFYR----GCM-TLEVNRRLLDL-- 655

  Fly   726 FARVQDSASVKPSCHVQANVC 746
                 |.|:.|.| .:.|:.|
Human   656 -----DEAAYKHS-DITAHSC 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058
		EGF_CA	311..347	CDD:238011	10/43 (23%)
		Laminin_G_2	386..517	CDD:280389	35/146 (24%)
		LamG	555..716	CDD:238058	38/178 (21%)
		EGF	746..777	CDD:278437	1/1 (100%)
		Laminin_G_2	814..945	CDD:280389
		LamG	988..1136	CDD:238058
		EGF	1164..1195	CDD:278437
		Laminin_G_2	1233..1356	CDD:280389
GAS6	NP_000811.1	Gla	53..92	CDD:306960
		EGF_CA	118..153	CDD:238011
		FXa_inhibition	160..195	CDD:317114
		EGF_CA	197..>227	CDD:214542	8/31 (26%)
		vWFA	<232..273	CDD:320736	9/40 (23%)
		LamG	298..450	CDD:238058	38/173 (22%)
		Laminin_G_2	513..651	CDD:308045	34/167 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910