DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-1 and Shbg

DIOPT Version :9

Sequence 1:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster
Sequence 2:	XP_006246648.1	Gene:	Shbg / 24775	RGDID:	3671	Length:	445	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	108/544 - (19%)
Similarity:	181/544 - (33%)	Gaps:	188/544 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 FRGAIRNLVYADQPGGSTRRQEIKQQRDIKCG--------DVPCDHGELPARERPLRGVRGGNTT 310
            ||||..: .|::..||.....|..:...::|.        .:|..|     :.|.||.:
  Rat    24 FRGAAWS-GYSEPLGGQLLTMEKGEVASLRCRLLLLLLLLTLPPTH-----QGRTLRHI------ 76

  Fly   311 DACERNDPCQHGGICISTDSGPICECRNLEYDGQYCEKEKAPSEATFRGTQFLSYDLGQTGAEPI 375
                  ||.|      |....|                           .::||...||   ||:
  Rat    77 ------DPIQ------SAQDSP---------------------------AKYLSNGPGQ---EPV 99

  Fly   376 V--------SAQDAISFYFRTRQPNGLLFY--TGHGTDYLNLALRDGGVSLTMGLANGKQEMHIK 430
            .        .::.:.||.|||..|.|::||  |....|:..|.||||.:.:.:.....:..:...
  Rat   100 TVLTIDLTKISKPSSSFEFRTWDPEGVIFYGDTNTEDDWFMLGLRDGQLEIQLHNLWARLTVGFG 164

  Fly   431 PSKVRFDDHQWHKVTVHRR----IQEISSITSFCRLVTVVDDVYTDHSHIAGKFTMLSSSRVYVG 491
            |   |.:|.:||.|.:...    :..:......|  :..|.....||..:        |.|:.:|
  Rat   165 P---RLNDGRWHPVELKMNGDSLLLWVDGKEMLC--LRQVSASLADHPQL--------SMRIALG 216

  Fly   492 GAVNPRALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQCPSGD----- 551
            |.:.|.:.|...:.....||:|:..:......|:.......|:..:.:...|.:  |.|.
  Rat   217 GLLLPTSKLRFPLVPALDGCIRRDIWLGHQAQLSTSARTSLGNCDVDLQPGLFF--PPGTHAEFS 279

  Fly   552 ----PQ---DPVTFTTRESHLVLPPWETGKQSSISFKFRTKEPNG-IIVLATGSK---------- 598
                ||   ||.||                  |:...|:..:..| ::.|.||:.
  Rat   280 LQDIPQPHTDPWTF------------------SLELGFKLVDGAGRLLTLGTGTNSSWLTLHLQD 326

  Fly   599 ---------QPRAKNPVLIAIELLNGHIYIHLDLGSGASKVRASRRRVDDGDWHDLILRRNGRDA 654
                     :|:...|:.:.:.|     .:.||:    .||..|:     |...:::     ..:
  Rat   327 QTVVLSSEAEPKLALPLAVGLPL-----QLKLDV----FKVALSQ-----GPKMEVL-----STS 372

  Fly   655 KVSVDGVWNDFRTPGDGTILELDGHMYLGGVGPAYNSVSWPAAIWTATLRQGFVGCLRDLVLSGK 719
            .:.:..:|..:..|        .||:.||.:....:|.|:               ||.||.:.|:
  Rat   373 LLRLASLWRLWSHP--------QGHLSLGALPGEDSSASF---------------CLSDLWVQGQ 414

  Fly   720 AIDI-AAFARVQD----SASVKPS 738
            .:|| .|.:|.||    |....||
  Rat   415 RLDIDKALSRSQDIWTHSCPQSPS 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058	4/8 (50%)
		EGF_CA	311..347	CDD:238011	5/35 (14%)
		Laminin_G_2	386..517	CDD:280389	33/136 (24%)
		LamG	555..716	CDD:238058	30/180 (17%)
		EGF	746..777	CDD:278437
		Laminin_G_2	814..945	CDD:280389
		LamG	988..1136	CDD:238058
		EGF	1164..1195	CDD:278437
		Laminin_G_2	1233..1356	CDD:280389
Shbg	XP_006246648.1	Laminin_G_1	118..248	CDD:278483	33/142 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910