DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrx-1 and Lamc1

DIOPT Version :9

Sequence 1:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster
Sequence 2:	NP_034813.2	Gene:	Lamc1 / 226519	MGIID:	99914	Length:	1607	Species:	Mus musculus

Alignment Length:	808	Identity:	159/808 - (19%)
Similarity:	240/808 - (29%)	Gaps:	292/808 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 TLSAGFQLDGSQNSFYTFRKWYTGLNGTL-----------ELEFKTEQPNGLVLY---TDDGG-- 148
            |:.||.|...|             :|.||           .|:|.|.:|....:|   .:||.
Mouse   120 TMLAGVQYPNS-------------INLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWI 171

  Fly   149 TYDFFELKLVEGALRLRYNLGGGAQIITVGRELHDGHWHKVQVLRNDEQTSLIVDGVSQQRSTKG 213
            .|.::     .|:....|:......|.|.|                |||.:|..|..|......|
Mouse   172 PYQYY-----SGSCENTYSKANRGFIRTGG----------------DEQQALCTDEFSDISPLTG 215

  Fly   214 KEFQFGKFA--------SNSDVYVGGMPNWYSS---KLALLAL----PSVIFEPRFRGAIRNLVY 263
            ....|....        .||.|    :..|.::   ::.|..|    ..|..:|:   .:::..|
Mouse   216 GNVAFSTLEGRPSAYNFDNSPV----LQEWVTATDIRVTLNRLNTFGDEVFNDPK---VLKSYYY 273

  Fly   264 ADQP---GGSTR-----RQEIKQQRD-IKCGDVPCDHGE--------LP-ARERPLRGVRGGNTT 310
            |...   ||..:     .:.:|.:.| :.|.   |.|..        || ..:||.|.....:.:
Mouse   274 AISDFAVGGRCKCNGHASECVKNEFDKLMCN---CKHNTYGVDCEKCLPFFNDRPWRRATAESAS 335

  Fly   311 DA--CERNDPCQ-------------HGGICISTDSGPICECRNLEYDGQYCEKEKAPSEATFRGT 360
            :.  |:.|...|             |||.|.:        ||: ..||..||:.:   |..||
Mouse   336 ECLPCDCNGRSQECYFDPELYRSTGHGGHCTN--------CRD-NTDGAKCERCR---ENFFR-- 386

  Fly   361 QFLSYDLGQTGA------EPIVSAQDAISFYFRTRQPNGLLFYTGHGTDYLNLALRDGGVSLTMG 419
                  ||.|.|      .|:.|.......|.|.....|::   |...|    ..:.|..|||
Mouse   387 ------LGNTEACSPCHCSPVGSLSTQCDSYGRCSCKPGVM---GDKCD----RCQPGFHSLT-- 436

  Fly   420 LANGKQEMHIKPSKVRFDDHQWHKVTVHRRIQEISSITSFCRLVT----VVDDV--YTDHSHIAG 478
                  |...:|...                 :.|..|..|.:.|    ..|:|  :.......|
Mouse   437 ------EAGCRPCSC-----------------DPSGSTDECNVETGRCVCKDNVEGFNCERCKPG 478

  Fly   479 KFTMLSSSRVYVGGAVNPRALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKLIQVAG-- 541
            .|.:.||         ||:.........:...|...|.:|...:: :...:.:.|.::.|..|
Mouse   479 FFNLESS---------NPKGCTPCFCFGHSSVCTNAVGYSVYDIS-STFQIDEDGWRVEQRDGSE 533

  Fly   542 -NLEYQCPSGDPQDPVTFTTR--ESHLVLPPWETGKQ-----SSISFKFRTK------------- 585
             :||:   |.|.||....:..  ..:.:.|....|.|     .::||.||..
Mouse   534 ASLEW---SSDRQDIAVISDSYFPRYFIAPVKFLGNQVLSYGQNLSFSFRVDRRDTRLSAEDLVL 595

  Fly   586 EPNGIIV----LATGSKQPRAK----------------NPVLIAIE---LLNGHIYIHLDLGSGA 627
            |..|:.|    :|.|:..|...                .|.|...|   |||....|
Mouse   596 EGAGLRVSVPLIAQGNSYPSETTVKYIFRLHEATDYPWRPALSPFEFQKLLNNLTSI-------- 652

  Fly   628 SKVRASRRRVDDGDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTILELDGHMYLGGVGPAYNSV 692
             |:|.:......|...|:.|:.                ..||.|.              ||
Mouse   653 -KIRGTYSERSAGYLDDVTLQS----------------ARPGPGV--------------PA---- 682

  Fly   693 SWPAAIWTATLRQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSCHVQANVCNG-----NPCL 752
            :|   :.:.|...|:.|...:..|.|..         :::.|:.|........|||     :|..
Mouse   683 TW---VESCTCPVGYGGQFCETCLPGYR---------RETPSLGPYSPCVLCTCNGHSETCDPET 735

  Fly   753 NGGTCLEGWNRPICD-CSATLYGGPTCG 779
            ....|.:....|.|: ||...||..|.|
Mouse   736 GVCDCRDNTAGPHCEKCSDGYYGDSTLG 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058	33/183 (18%)
		EGF_CA	311..347	CDD:238011	11/50 (22%)
		Laminin_G_2	386..517	CDD:280389	24/136 (18%)
		LamG	555..716	CDD:238058	34/203 (17%)
		EGF	746..777	CDD:278437	11/36 (31%)
		Laminin_G_2	814..945	CDD:280389
		LamG	988..1136	CDD:238058
		EGF	1164..1195	CDD:278437
		Laminin_G_2	1233..1356	CDD:280389
Lamc1	NP_034813.2	LamNT	42..282	CDD:214532	39/202 (19%)
		EGF_Lam	283..328	CDD:238012	9/47 (19%)
		Laminin_EGF	340..394	CDD:278482	20/73 (27%)
		Laminin_EGF	396..443	CDD:278482	12/61 (20%)
		Laminin_EGF	443..490	CDD:278482	12/72 (17%)
		LamB	551..676	CDD:214597	25/149 (17%)
		Laminin_EGF	722..761	CDD:278482	11/38 (29%)
		EGF_Lam	770..818	CDD:238012
		Laminin_EGF	826..873	CDD:278482
		Laminin_EGF	882..930	CDD:278482
		EGF_Lam	933..978	CDD:214543
		EGF_Lam	980..1027	CDD:238012
		Domain II and I	1029..1607
		SPEC	1047..1252	CDD:295325
		MA	1089..1300	CDD:214599
		V_Alix_like	1178..>1310	CDD:187408
		DUF5089	1198..1403	CDD:293607
		SH3BP5	1359..1585	CDD:283045
		ATP-synt_B	<1391..1503	CDD:304375
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910