DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nrx-1 and Nrxn3

DIOPT Version :9

Sequence 1:NP_001262840.1 Gene:Nrx-1 / 42646 FlyBaseID:FBgn0038975 Length:1847 Species:Drosophila melanogaster
Sequence 2:XP_036013122.1 Gene:Nrxn3 / 18191 MGIID:1096389 Length:1584 Species:Mus musculus


Alignment Length:1798 Identity:564/1798 - (31%)
Similarity:871/1798 - (48%) Gaps:326/1798 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 LIVSALLVSLAASFVTLSAGFQLDGSQNSFYTFRKWYTGLNGTLELEFKTEQPNGLVLYTDDGGT 149
            |.||..|.||    |.|..|.:..|..|.:..:.:|.......|..:|||....||:||.||||.
Mouse    12 LKVSIFLGSL----VGLCLGLEFMGLPNQWARYLRWDASTRSDLSFQFKTNVSTGLLLYLDDGGV 72

  Fly   150 YDFFELKLVEGALRLRYNLGGGAQIITVGRELHDGHWHKVQVLRNDEQTSLIVDGVSQQRSTKGK 214
            .||..|.||:|.::||:::......:...::::|..||.:.|.|:..:|.|::||          
Mouse    73 CDFLCLSLVDGRVQLRFSMDCAETTVLSNKQVNDSSWHFLMVSRDRVRTGLVIDG---------- 127

  Fly   215 EFQFGKFASN-------SDVYVGGMPNWYSSKLALLALPSVIFEPRFRGAIRNLVYADQPGGSTR 272
            |.|.|:....       ||:::||:|  ...:.:.|.|..|...|.|:|.:.:|.|.:.......
Mouse   128 EGQSGELRPQRPYMDVVSDLFLGGVP--ADIRPSALTLDGVQSMPGFKGLMLDLKYGNSEPRLLG 190

  Fly   273 RQEIKQQRDIKCGDVPCDHGELPARERPLRGVRGGNTTDACERNDPCQHGGICISTDSGPICECR 337
            .|.::.:.:..||                            ||  ||::||||...|..|.|:|.
Mouse   191 SQSVQLEAEGPCG----------------------------ER--PCENGGICFLLDGHPTCDCS 225

  Fly   338 NLEYDGQYCEKE------------------KAPSE--ATFRGTQFLSYDLGQTGAEPIVSAQDAI 382
            ...|.|..|.::                  ||..|  |||||:::|.|||.|   .||.|:.|.|
Mouse   226 TTGYGGTLCSEDVSQGPGLSHLMMSEQGRSKAREENVATFRGSEYLCYDLSQ---NPIQSSSDEI 287

  Fly   383 SFYFRTRQPNGLLFYTGHGTDYLNLALRDGGVSLTMGLANGKQEMHIKPSKVRFDDHQWHKVTVH 447
            :..|:|.|.|||:.:||...||:||||:||.|||.:.|.:|..|..::|...:|:|:.||.|.|.
Mouse   288 TLSFKTWQRNGLILHTGKSADYVNLALKDGAVSLVINLGSGAFEAIVEPVNGKFNDNAWHDVKVT 352

  Fly   448 RRIQEISSITSFCRLVTV-VDDVYTDHSHIAGKFTMLSSSR-VYVGGAVNPRALLGARVHTNFVG 510
            |.:          |.||: ||.:.|...:....:|||.|.. .||||:.:...|.|:.|..||:|
Mouse   353 RNL----------RQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMG 407

  Fly   511 CLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQCPSGDPQDPVTFTTRESHLVLPPWETGKQ 575
            ||::|.:..:.:.|.|..||:.|...:::.|.:.::|.:....||:.|.|.|:::.||.|.|.:.
Mouse   408 CLKEVVYKNNDIRLELSRLARIGDTKMKIYGEVVFKCENVATLDPINFETPEAYISLPKWNTKRM 472

  Fly   576 SSISFKFRTKEPNGIIVLATGSKQPR-----AKNPVL--IAIELLNGHIYIHLDLGSGASKVRAS 633
            .||||.|||.||||:|:...|..|.|     .||..:  .|:|||:|::|:.||:|||..||:|:
Mouse   473 GSISFDFRTTEPNGLILFTHGKPQERKDVRSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKAT 537

  Fly   634 RRRVDDGDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTILELDGHMYLGGVGPAYNSVSWPAAI 698
            :::.:||:|:.:.::|:||...:||:.....|...|:..||:|:|.|||||:......:..|..:
Mouse   538 QKKANDGEWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTEL 602

  Fly   699 WTATLRQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSC-HVQANVCNGNPCLNGGTCLEGWN 762
            |||.|..|:|||:|||.:.|::.:|...|.:|::|.||.|| .:.|..|:..||.|...|.:|||
Mouse   603 WTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWN 667

  Fly   763 RPICDCSATLYGGPTCGRELATLAFNGSQHMTIWLGNGQGTKTQTEELVIRFKTSRPAGLLLLTS 827
            |.||||:.|.|.|.||.||.:.|:::||.:|.:.:  .....|:.|::..||.:.|..|||:.|:
Mouse   668 RFICDCTGTGYWGRTCEREASILSYDGSMYMKVIM--PMVMHTEAEDVSFRFMSQRAYGLLVATT 730

  Fly   828 AESNSPDRLEIALVAGRVRASVRL---------SDREKNLLAGQSVLNDNNWHTIRFSRRASNLR 883
            :. :|.|.|.:.|..|||:..|.|         |...:.|.|||. ||||.|||:|..||..:|:
Mouse   731 SR-DSADTLRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQK-LNDNEWHTVRVVRRGKSLK 793

  Fly   884 LQVDGAPPVRGMLSETILGRHSTMEIRSVHLGGLFHAEEEIQMTSTMP-NFVGQMQGLVFNGQRY 947
            |.||.     .:...|::|.|:.:|..::..|.:    .|.:..|.:| :|:|.:|.|:|||..|
Mouse   794 LTVDD-----DVAEGTMVGDHTRLEFHNIETGIM----TEKRYISVVPSSFIGHLQSLMFNGLLY 849

  Fly   948 LDIVKSLGPELSALPSATFKLTARF-VNSPAGQPYHAATFRSKHSYVGLAMLKAYNSISIDFRFK 1011
            :|:.|:...:..       :|.||| :.:....|   .||::|.||:.||.|:||.|:.:.|:||
Mouse   850 IDLCKNGDIDYC-------ELKARFGLRNIIADP---VTFKTKSSYLTLATLQAYTSMHLFFQFK 904

  Fly  1012 TVEPNGLLVFNGGRRNDFVAVELVNGHIHYTFDLGDGPVTMRDKSRIHMNDNRWHQVSIRRPGPK 1076
            |...:|.::||.|..|||:|||||.|:|||.||||:||..::..|...:|||:||.|.|.|....
Mouse   905 TTSADGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDSSN 969

  Fly  1077 THTLTVDDSFEIISLTGNNMHLELAGILYIGGVFKDMYSKLPASISSRSGFEGCLASLDLGDASP 1141
            ||:|.||... :..:.....:|:|.|.||:.|:.:.|||.||..::||.||:|||||:||....|
Mouse   970 THSLKVDTKV-VTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLP 1033

  Fly  1142 SLTSDAVVPSSLVVSGCE---------GP-TKCSQNACANRGNCVQQWNAYACECDMTSYTGPTC 1196
            .|.:||:..|..:..|||         || |.|.:::|||:|.|:|||..:.|:|.||||:|..|
Mouse  1034 DLINDALHRSGQIERGCEVALTKADLQGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQC 1098

  Fly  1197 YDESIAYEFGNNKGMVQYTFPENAQADTEEDNIALGFITTRPDAVLLRVESAT-TQDYMELEIVE 1260
            .|....|.||.:.|::.||:|.|.:..|..|.:|:||.||..|.:|:|::||. ..|:::|.|.:
Mouse  1099 NDPGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQ 1163

  Fly  1261 GNIFMVYNIGSVDLPLGEIGTKVNDNAYHVVRFQRKGGNATLQLDDYNV---------------- 1309
            |.|.:|:|||:||:.:.|..|.|||..||||||.|.|||||||:|::.|                
Mouse  1164 GKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGNTDNERLQM 1228

  Fly  1310 --------------QALTPQSHHSTVFNTMSNVQVGGKFSRNGRNRIERPFAGVIAGLSVNKLRI 1360
                          :.|..:....|:|||.:.:.:|||    .:.|:   |.|.::||..:.|::
Mouse  1229 VKQKIPFKYNRPVEEWLQEKGRQLTIFNTQAQIAIGGK----DKGRL---FQGQLSGLYYDGLKV 1286

  Fly  1361 LDLAVERDPHITIRGDVQLVTGVLDRNDLQRMQQTLNSTRQTPASGYPGALDDLIFSGAGSGCRG 1425
            |::|.|.:|:|.|.|.|:||..|          .:::.|.||.:                     
Mouse  1287 LNMAAENNPNIKINGSVRLVGEV----------PSVSGTTQTTS--------------------- 1320

  Fly  1426 DDEDECTPPFESGSGDDLITPVYVPPTKQTTTSQQGNSLSTGGSSSGGVITNGTERACDDEDCVH 1490
                  .||       ::.|.|....|...||:.:.|..:.....:...:.:..|.:.||||.| 
Mouse  1321 ------MPP-------EMSTTVMETTTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFV- 1371

  Fly  1491 GSGDYGETTEQFTSTSTARGSESNNEMVTITTTGRSDVTTEQHQGSSSSSSSGSTPSYATTQSSS 1555
               :...:|::..|||...|                        |..:.:....:..:       
Mouse  1372 ---ECEPSTDKSLSTSIFEG------------------------GYKAHAPKWESKDF------- 1402

  Fly  1556 SSSSGGSAASTPGQVSTTSSVATSSTQRATSSSTSTSSS---TTSTTTTTTTTQATPPPEIRSTV 1617
                      .|.:||.||...|:|........|::|||   ..............|.|:|   |
Mouse  1403 ----------RPNKVSETSRTTTTSLSPELIRFTASSSSGMVPKLPAGKMNNRDLKPQPDI---V 1454

  Fly  1618 TERETTPYDIYIAGGGMGGSGRNDHDRMQLPDEHHPLPPLPPPIPPQDPPPYGPYGGNTYNTNMN 1682
            .....|.|::             |..:::.|....|:....|...|.:|                
Mouse  1455 LLPLPTAYEL-------------DSTKLKSPLITSPMFRNVPTANPTEP---------------- 1490

  Fly  1683 NYRPKGKGGRINSIEEERTAMIIGIVAGILIAVVLVILLVLWLKSNGDRG-YKTESEKAAAYGSH 1746
            ..|.......:.......|.|::||||...:. :|::|..::...|.|.| |:.:..:     ::
Mouse  1491 GIRRVPGASEVIRESSSTTGMVVGIVAAAALC-ILILLYAMYKYRNRDEGSYQVDETR-----NY 1549

  Fly  1747 NPNAALLGNTSTNGSYHQQRQHHMHGGGGGGGAGQQQHHAQQQ 1789
            ..|:|     .:||:..:::|           |..:..|.:|:
Mouse  1550 ISNSA-----QSNGTLMKEKQ-----------ASSKSGHKKQK 1576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nrx-1NP_001262840.1 LamG 110..263 CDD:238058 46/159 (29%)
EGF_CA 311..347 CDD:238011 14/35 (40%)
Laminin_G_2 386..517 CDD:280389 53/132 (40%)
LamG 555..716 CDD:238058 70/167 (42%)
EGF 746..777 CDD:278437 16/30 (53%)
Laminin_G_2 814..945 CDD:280389 48/140 (34%)
LamG 988..1136 CDD:238058 69/147 (47%)
EGF 1164..1195 CDD:278437 16/30 (53%)
Laminin_G_2 1233..1356 CDD:280389 53/153 (35%)
Nrxn3XP_036013122.1 LamG 27..181 CDD:238058 48/165 (29%)
EGF 202..231 CDD:394967 15/58 (26%)
LamG 286..417 CDD:214598 54/140 (39%)
LamG 474..623 CDD:214598 62/148 (42%)
EGF_CA 651..684 CDD:238011 17/32 (53%)
LamG 712..846 CDD:214598 48/144 (33%)
Laminin_G_2 903..1031 CDD:396680 61/128 (48%)
LamG 1104..1283 CDD:238058 65/185 (35%)
Syndecan 1510..>1545 CDD:395821 11/35 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 134 1.000 Domainoid score I4986
eggNOG 1 0.900 - - E1_KOG3514
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H83225
Inparanoid 1 1.050 841 1.000 Inparanoid score I441
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46386
OrthoDB 1 1.010 - - D24127at33208
OrthoFinder 1 1.000 - - FOG0001168
OrthoInspector 1 1.000 - - otm44073
orthoMCL 1 0.900 - - OOG6_103392
Panther 1 1.100 - - O PTHR15036
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X794
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.840

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