DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nrx-1 and Nrxn2

DIOPT Version :9

Sequence 1:NP_001262840.1 Gene:Nrx-1 / 42646 FlyBaseID:FBgn0038975 Length:1847 Species:Drosophila melanogaster
Sequence 2:NP_001356292.1 Gene:Nrxn2 / 18190 MGIID:1096362 Length:1710 Species:Mus musculus


Alignment Length:1874 Identity:596/1874 - (31%)
Similarity:874/1874 - (46%) Gaps:389/1874 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 QVPPVVVEYRRSYRVLIVSALLVSLAASFVTLSAGFQLDGSQNSFYTFRKWYTGLNGTLELEF-- 132
            |:||::              ||::|||..    .|.:..|....:..:.:| .|...|.||.|  
Mouse    12 QLPPLL--------------LLLALAAGV----RGLEFGGGPGQWARYARW-AGAASTGELSFSL 57

  Fly   133 KTEQPNGLVLYTDDGGTYDFFELKLVEGALRLRYNLG-GGAQIITVGRELHDGHWHKVQVLRNDE 196
            :|.....|:||.||||..||.||.||:|.||||:.|. .....:.:...:.|..||.|.:.|:..
Mouse    58 RTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDAR 122

  Fly   197 QTSLIVDGVSQQRSTKGK--EFQFGKFASNSDVYVGGMPNWYSSKLALLALPSVIFEPRFRGAIR 259
            :|:|.|||.::....:.|  |.|..     ||::|||:|.  ..:|:.|.|.:|.:||.|||.:.
Mouse   123 RTALAVDGEARAAEVRSKRREMQVA-----SDLFVGGIPP--DVRLSALTLSTVKYEPPFRGLLA 180

  Fly   260 NLVYADQPGGSTRRQEIKQQRDIKCGDVPCDHGELPARERPLRGVRGGNTTDAC--ERNDPCQHG 322
            ||...::|                    |...|.        :|:||......|  .|| ||.:|
Mouse   181 NLKLGERP--------------------PALLGS--------QGLRGAAADPLCAPARN-PCANG 216

  Fly   323 GICISTDSGPI-CECRNLEYDGQYCEKEKAPSE-------------------------------- 354
            |:|.....|.: |:|.:..:.|::|.:|:.|.|                                
Mouse   217 GLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQP 281

  Fly   355 --------ATFRGTQFLSYDLGQTGAEPIVSAQDAISFYFRTRQPNGLLFYTGHGTDYLNLALRD 411
                    |||:|.:|..|||..   .||.|:.|.|:..|||.|.|||:.:||...||:||:|:.
Mouse   282 TKGKEEFVATFKGNEFFCYDLSH---NPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKS 343

  Fly   412 GGVSLTMGLANGKQEMHIKPSKVRFDDHQWHKVTVHRRIQEISSI-----TSFCRLVTV-VDDVY 470
            |.|.|.:.|.:|..|..::|...:|:|:.||.|.|.|.:::.:.|     .....|||: ||.:.
Mouse   344 GAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGIL 408

  Fly   471 TDHSHIAGKFTMLSSSR-VYVGGAVNPRALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGS 534
            |...:....:|||.|.. .|:||:.|...|.|:.|..||:|||:.|.:..:...|.|..|||.|.
Mouse   409 TTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGD 473

  Fly   535 KLIQVAGNLEYQCPSGDPQDPVTFTTRESHLVLPPWETGKQSSISFKFRTKEPNGIIVLATG--- 596
            ..:::.|:|.::|......|||||.:.|:.:.||.|...:..|||..|||.||||:::.:.|   
Mouse   474 PKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRA 538

  Fly   597 -------SKQPRAKNPVLIAIELLNGHIYIHLDLGSGASKVRASRRRVDDGDWHDLILRRNGRDA 654
                   |...||.   ..|:|||:|::|:.||:|||..|:|||.|:|:||:|..:..:|:||..
Mouse   539 GAGVGSHSSTQRAD---YFAMELLDGYLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKG 600

  Fly   655 KVSVDGVWNDFRTPGDGTILELDGHMYLGGVGPAYNSVS--WPAAIWTATLRQGFVGCLRDLVLS 717
            .:||:.....|...|:..:|:|:..:||||: |....|.  .|..:|||.||.|:|||:|||.:.
Mouse   601 SISVNSRSTPFLATGESEVLDLESELYLGGL-PEGGRVDLPLPPEVWTAALRAGYVGCVRDLFID 664

  Fly   718 GKAIDIAAFARVQDSASVKPSCHVQA-NVCNGNPCLNGGTCLEGWNRPICDCSATLYGGPTCGRE 781
            |::.|:...|..|.:..|.|.|..:. ..|...||.|||.|.|||||.:|||..|.:.|..|.||
Mouse   665 GRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGICREGWNRFVCDCIGTGFLGRVCERE 729

  Fly   782 LATLAFNGSQHMTIWLGNGQGTKTQTEELVIRFKTSRPAGLLLLTSAESNSPDRLEIALVAGRVR 846
            ...|:::||.:|.|.|....  .|:.|::.:||.:.|..||::.|::. .|.|.|.:.|..|::|
Mouse   730 ATVLSYDGSMYMKIMLPTAM--HTEAEDVSLRFMSQRAYGLMMATTSR-ESADTLRLELDGGQMR 791

  Fly   847 ASVRL---------SDREKNLLAGQSVLNDNNWHTIRFSRRASNLRLQVDGAPPVRGMLSETILG 902
            .:|.|         |...:.|.||.. ||||.|||:|..||..:|:|.||.. .|.|.::    |
Mouse   792 LTVNLDCLRVGCAPSKGPETLFAGHK-LNDNEWHTVRVVRRGKSLQLSVDNV-TVEGQMA----G 850

  Fly   903 RHSTMEIRSVHLGGLFHAEEEIQMTSTMP-NFVGQMQGLVFNGQRYLDIVKSLGPELSALPSATF 966
            .|:.:|..::..|.:    .|.:..|.:| ||:|.:.|||||||.|:|..|.        ...|:
Mouse   851 AHTRLEFHNIETGIM----TERRFISVVPSNFIGHLSGLVFNGQPYMDQCKD--------GDITY 903

  Fly   967 -KLTARF-VNSPAGQPYHAATFRSKHSYVGLAMLKAYNSISIDFRFKTVEPNGLLVFNGGRRNDF 1029
             :|.||| :.:....|   .||:|:.||:.||.|:||.|:.:.|:|||..|:|||:||.|..|||
Mouse   904 CELNARFGLRAIVADP---VTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDF 965

  Fly  1030 VAVELVNGHIHYTFDLGDGPVTMRDKSRIHMNDNRWHQVSIRRPGPKTHTLTVDDSFEIISLTGN 1094
            :.:|||.|:|||.||||:||..|:..|...:|||:||.|.:.|.....|||.: ||..:...:..
Mouse   966 IVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKI-DSRTVTQHSNG 1029

  Fly  1095 NMHLELAGILYIGGVFKDMYSKLPASISSRSGFEGCLASLDLGDASPSLTSDAVVPSSLVVSGCE 1159
            ..:|:|.|.|||||:.|:|:|.||..::||.||:|||||:||....|.|.:||:.....|..||:
Mouse  1030 ARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCD 1094

  Fly  1160 GP-TKCSQNACANRGNCVQQWNAYACECDMTSYTGPTCYDESIAYEFGNNKGMVQYTFPENAQAD 1223
            || |.|::.:|||:|.|:|||:.:.|:|.||||.||.|.|....|.||....::.||:|.|.:..
Mouse  1095 GPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPS 1159

  Fly  1224 TEEDNIALGFITTRPDAVLLRVESAT-TQDYMELEIVEGNIFMVYNIGSVDLPLGEIGTKVNDNA 1287
            |..|.:|:||.|.:..|||:||:||: ..||::|.|.:|.:.:::|:|:.|:.:.|....|:|..
Mouse  1160 TRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGK 1224

  Fly  1288 YHVVRFQRKGGNATLQLDDYNVQALTP------------------------------QSHHSTVF 1322
            ||||||.|.|||||||:|.:.|....|                              :....|:|
Mouse  1225 YHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIF 1289

  Fly  1323 NTMSNVQVGGKFSRNGRNRIERPFAGVIAGLSVNKLRILDLAVERDPHITIRGDVQLV------- 1380
            |:.:.:::||:..       .|||.|.::||..|.|::|.||.|.||::...|.::||       
Mouse  1290 NSQAAIKIGGRDQ-------GRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVL 1347

  Fly  1381 -------TGVLDRNDLQRMQQTLNSTRQTPASGYPGAL--------DDLIFSGAGSGCRGDDED- 1429
                   |.:|.......|:.|......|...|....:        |||:.  |.:.|..|||| 
Mouse  1348 LSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTMRDSTTQNTDDLLV--ASAECPSDDEDL 1410

  Fly  1430 -ECTPPFESGSGDDLITPV----------------YVPP-------------TKQTTTSQQGNSL 1464
             ||.|    .:|.:||.|:                :|||             |:.|.........
Mouse  1411 EECEP----STGGELILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRP 1471

  Fly  1465 STGGSSSGGVITNGTERACDDEDC---VHGSGDYGETTEQFTSTSTARGSESNNEMVTITTTGRS 1526
            |:||...       .||  ||.||   |..||        |.|                      
Mouse  1472 SSGGPCQ-------AER--DDSDCEEPVEASG--------FAS---------------------- 1497

  Fly  1527 DVTTEQHQGSSSSSSSGSTPSYATTQSSSSSSSGGSAASTPGQVSTTSSVATSSTQRATSSSTST 1591
                                                     |:|..:|...|......|:....|
Mouse  1498 -----------------------------------------GEVFDSSLPPTDDEDFYTTFPLVT 1521

  Fly  1592 SSSTTSTTTTTTTTQATPPPEIRSTVTERETTPYDIYIAGGGMG---GSGRNDH-DRMQLPDEHH 1652
            .       .||..:...|.|.:|   |:..|....:..|.....   .:|:.:| |.:|      
Mouse  1522 D-------RTTLLSPRKPRPNLR---TDGATGAPGVLFAPSAPAPNLPAGKMNHRDPLQ------ 1570

  Fly  1653 PL---PPLPPPIP----PQDPPPYGPYGGNTY--------NTNMNNYRPKGKGGRINSIEE--ER 1700
            ||   |||.|.:|    |:.|||..|  |.|.        ..|......:|..|.:..|.|  ..
Mouse  1571 PLLENPPLGPGVPTAFEPRRPPPLRP--GVTSAPGFPRLPTANPTGPGERGPPGAVEVIRESSST 1633

  Fly  1701 TAMIIGIVAGILIAVVLVILLVLWLKSNGDRG-YKTESEKAAAYGSHNPNAALL 1753
            |.|::||||...:. :|::|..::...|.|.| |:.:..:.....|...|.|::
Mouse  1634 TGMVVGIVAAAALC-ILILLYAMYKYRNRDEGSYQVDQSRNYISNSAQSNGAVV 1686

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nrx-1NP_001262840.1 LamG 110..263 CDD:238058 56/157 (36%)
EGF_CA 311..347 CDD:238011 12/38 (32%)
Laminin_G_2 386..517 CDD:280389 52/137 (38%)
LamG 555..716 CDD:238058 70/172 (41%)
EGF 746..777 CDD:278437 17/30 (57%)
Laminin_G_2 814..945 CDD:280389 48/140 (34%)
LamG 988..1136 CDD:238058 72/147 (49%)
EGF 1164..1195 CDD:278437 16/30 (53%)
Laminin_G_2 1233..1356 CDD:280389 48/153 (31%)
Nrxn2NP_001356292.1 LamG 28..184 CDD:238058 58/163 (36%)
Laminin_G_2 318..456 CDD:308045 52/137 (38%)
LamG 516..666 CDD:214598 62/153 (41%)
EGF_CA 694..727 CDD:238011 17/32 (53%)
Laminin_G_2 760..890 CDD:308045 48/140 (34%)
Laminin_G_2 946..1074 CDD:308045 64/128 (50%)
Laminin_G_2 1169..1317 CDD:308045 48/154 (31%)
PHA03247 <1433..1630 CDD:223021 55/294 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1458..1508 19/129 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1587..1621 9/35 (26%)
Syndecan 1635..>1674 CDD:307260 11/39 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1677..1710 3/10 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167836760
Domainoid 1 1.000 134 1.000 Domainoid score I4986
eggNOG 1 0.900 - - E1_KOG3514
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 841 1.000 Inparanoid score I441
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46386
OrthoDB 1 1.010 - - D24127at33208
OrthoFinder 1 1.000 - - FOG0001168
OrthoInspector 1 1.000 - - otm44073
orthoMCL 1 0.900 - - OOG6_103392
Panther 1 1.100 - - LDO PTHR15036
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X794
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.770

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