DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nrx-1 and Nrxn1

DIOPT Version :9

Sequence 1:NP_001262840.1 Gene:Nrx-1 / 42646 FlyBaseID:FBgn0038975 Length:1847 Species:Drosophila melanogaster
Sequence 2:XP_011244620.1 Gene:Nrxn1 / 18189 MGIID:1096391 Length:1516 Species:Mus musculus


Alignment Length:1479 Identity:514/1479 - (34%)
Similarity:775/1479 - (52%) Gaps:184/1479 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 VLIVSALLVSLAASFVTLSAGFQLDGSQNSFYTFRKWYTGLNGTLELEFKTEQPNGLVLYTDDGG 148
            :|.:|.||:...|.   |.:|.:..|::..:..|.||.......:..:.||....|||||.||.|
Mouse    13 LLCLSLLLLGCWAE---LGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEG 74

  Fly   149 TYDFFELKLVEGA-LRLRYNL-GGGAQIITVGRELHDGHWHKVQVLRNDEQTSLIVD-GVSQQRS 210
            ..||.||.|..|. |:|.::: ......:.....::||.||.|::.|....|:|.:| ..::...
Mouse    75 FCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDRAEAKWVE 139

  Fly   211 TKGKEFQFGKFASNSDVYVGGMPNWYSSKLALLALPSVIFEPRFRGAIRNL-VYADQPGGSTRRQ 274
            .|.|......|   |.::|||:|....:....|.|.||.....|:|.||:: |.:.|.       
Mouse   140 VKSKRRDMTVF---SGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQA------- 194

  Fly   275 EIKQQRDIKCGDVPCDHGELPARERPLRGVRGGNTTDACERND--PCQHGGICISTDSGPICECR 337
                        :|.|.||:...:.|... .||:..:|.|..:  .|.:||:|...|...:|:|.
Mouse   195 ------------LPVDGGEVKLDDEPPNS-GGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCS 246

  Fly   338 NLEYDGQYCEKE------------------KAPSE--ATFRGTQFLSYDLGQTGAEPIVSAQDAI 382
            ...:.|:.|.:|                  |...|  |||:|:::..|||.|   .||.|:.|.|
Mouse   247 RTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQ---NPIQSSSDEI 308

  Fly   383 SFYFRTRQPNGLLFYTGHGTDYLNLALRDGGVSLTMGLANGKQEMHIKPSKVRFDDHQWHKVTVH 447
            :..|:|.|.|||:.:||...||:||||::|.|||.:.|.:|..|..::|...:|:|:.||.|.|.
Mouse   309 TLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVT 373

  Fly   448 RRIQEISSITSFCRLVTV-VDDVYTDHSHIAGKFTMLSSSR-VYVGGAVNPRALLGARVHTNFVG 510
            |.:::.|.|..  .:||: ||.:.|...:....:|||.|.. .||||:.:...|.|:.|..||:|
Mouse   374 RNLRQHSGIGH--AMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMG 436

  Fly   511 CLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQCPSGDPQDPVTFTTRESHLVLPPWETGKQ 575
            ||::|.:..:.:.|.|..|||.|...:::.|.:.::|.:....||:||.|.||.:.||.|...|.
Mouse   437 CLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKT 501

  Fly   576 SSISFKFRTKEPNGIIVLATGSKQPR----AKNPVLI-----AIELLNGHIYIHLDLGSGASKVR 631
            .||||.|||.||||:|:.:.|  :||    ||:|.:|     |||:|:||:|:.||:|||..|::
Mouse   502 GSISFDFRTTEPNGLILFSHG--KPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIK 564

  Fly   632 ASRRRVDDGDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTILELDGHMYLGGVGPAYNSVSWPA 696
            |.:::|:||:|:.:..:|:||...:||:.:...:..||:..||:||..:||||:......:.:|.
Mouse   565 ALQKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPT 629

  Fly   697 AIWTATLRQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSCHVQ-ANVCNGNPCLNGGTCLEG 760
            .:|||.|..|:|||:|||.:.|::.||...|.:|.:|.|||||..: |..|..|||.|.|.|.:|
Mouse   630 EVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEIQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDG 694

  Fly   761 WNRPICDCSATLYGGPTCGRELATLAFNGSQHMTIWLGNGQGTKTQTEELVIRFKTSRPAGLLLL 825
            |||.:||||.|.|.|.:|.||...|:::||..|.|.|  .....|:.|::.:||::.|..|:|:.
Mouse   695 WNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQL--PVVMHTEAEDVSLRFRSQRAYGILMA 757

  Fly   826 TSAESNSPDRLEIALVAGRVRASVRL---------SDREKNLLAGQSVLNDNNWHTIRFSRRASN 881
            |::. :|.|.|.:.|.||||:.:|.|         |...:.|.||.: ||||.|||:|..||..:
Mouse   758 TTSR-DSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYN-LNDNEWHTVRVVRRGKS 820

  Fly   882 LRLQVDGAPPVRGMLSETILGRHSTMEIRSVHLGGLFHAEEEIQMTSTMPNFVGQMQGLVFNGQR 946
            |:|.||....:.|.::    |.|:.:|..::..|.:   .|...::|...||:|.:|.|.|||..
Mouse   821 LKLTVDDQQAMTGQMA----GDHTRLEFHNIETGII---TERRYLSSVPSNFIGHLQSLTFNGMA 878

  Fly   947 YLDIVKSLGPELSALPSATFKLTARF-----VNSPAGQPYHAATFRSKHSYVGLAMLKAYNSISI 1006
            |:|:.|:...:..       :|.|||     :..|       .||::|.|||.||.|:||.|:.:
Mouse   879 YIDLCKNGDIDYC-------ELNARFGFRNIIADP-------VTFKTKSSYVALATLQAYTSMHL 929

  Fly  1007 DFRFKTVEPNGLLVFNGGRRNDFVAVELVNGHIHYTFDLGDGPVTMRDKSRIHMNDNRWHQVSIR 1071
            .|:|||...:||:::|.|..|||:.||||.|::||.||||:|...::..|...:|||:||.|.|.
Mouse   930 FFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMIS 994

  Fly  1072 RPGPKTHTLTVDDSFEIISLTGNNMHLELAGILYIGGVFKDMYSKLPASISSRSGFEGCLASLDL 1136
            |.....||:.:|... ...:|....:|:|...||||||.|:.|..||..:.::.||:|||||:||
Mouse   995 RDTSNLHTVKIDTKI-TTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDL 1058

  Fly  1137 GDASPSLTSDAVVPSSLVVSGCE---------GP-TKCSQNACANRGNCVQQWNAYACECDMTSY 1191
            ....|.|.|||:..:..:..|||         || |.|.:::|:|:|.|:|||:.::|:|.|||:
Mouse  1059 NGRLPDLISDALFCNGQIERGCEVALMKADLQGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSF 1123

  Fly  1192 TGPTCYDESIAYEFGNNKGMVQYTFPENAQADTEEDNIALGFITTRPDAVLLRVESAT-TQDYME 1255
            :||.|.|....|.|....|.:.|.:|.|.:..|..|.:|:||.|.:.:|||:||:|:: ..||:|
Mouse  1124 SGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLE 1188

  Fly  1256 LEIVEGNIFMVYNIGSVDLPLGEIGTKVNDNAYHVVRFQRKGGNATLQLDDYNV----------- 1309
            |.|.:|.|.:.:|:|:.|:.:.|....:||..||||||.|.|||||||:|.:.|           
Mouse  1189 LHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDN 1253

  Fly  1310 -------------------QALTPQSHHSTVFNTMSNVQVGGKFSRNGRNRIERPFAGVIAGLSV 1355
                               :.|..:....|:||:.:.:.:|||  ..|     :||.|.::||..
Mouse  1254 ERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGK--EQG-----QPFQGQLSGLYY 1311

  Fly  1356 NKLRILDLAVERDPHITIRGDVQLV-------------TGVLDRNDLQRMQQTLNSTRQTPASGY 1407
            |.|::|::|.|.|.:|.|.|:|:||             |.:........|:.|......|...|.
Mouse  1312 NGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGK 1376

  Fly  1408 P-------GALDDLIFSGAGSGCRGDDEDECTPPFESGSGDDLITPVYV 1449
            |       ...||::.  |.:.|..||||  ..|.|..|| .|..|..|
Mouse  1377 PPTKEPISQTTDDILV--ASAECPSDDED--IDPCEPSSG-GLANPTRV 1420

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nrx-1NP_001262840.1 LamG 110..263 CDD:238058 46/156 (29%)
EGF_CA 311..347 CDD:238011 10/37 (27%)
Laminin_G_2 386..517 CDD:280389 53/132 (40%)
LamG 555..716 CDD:238058 74/169 (44%)
EGF 746..777 CDD:278437 18/30 (60%)
Laminin_G_2 814..945 CDD:280389 47/139 (34%)
LamG 988..1136 CDD:238058 65/147 (44%)
EGF 1164..1195 CDD:278437 14/30 (47%)
Laminin_G_2 1233..1356 CDD:280389 50/153 (33%)
Nrxn1XP_011244620.1 LamG 30..190 CDD:238058 48/162 (30%)
LamG 307..446 CDD:214598 54/140 (39%)
LamG 503..652 CDD:214598 64/150 (43%)
EGF_CA 680..713 CDD:238011 18/32 (56%)
Laminin_G_2 746..874 CDD:366983 45/136 (33%)
Laminin_G_2 933..1058 CDD:366983 54/125 (43%)
LamG 1134..>1253 CDD:238058 47/118 (40%)
Syndecan 1441..>1480 CDD:366429
4.1m 1461..1479 CDD:128590
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 134 1.000 Domainoid score I4986
eggNOG 1 0.900 - - E1_KOG3514
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 841 1.000 Inparanoid score I441
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46386
OrthoDB 1 1.010 - - D24127at33208
OrthoFinder 1 1.000 - - FOG0001168
OrthoInspector 1 1.000 - - otm44073
orthoMCL 1 0.900 - - OOG6_103392
Panther 1 1.100 - - O PTHR15036
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R7419
SonicParanoid 1 1.000 - - X794
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1312.910

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