Protein Alignment Nrx-1 and lam-3

DIOPT Version :9

• Sequence 1: NP_001262840.1
• Gene: Nrx-1 / 42646
• FlyBaseID: FBgn0038975
• Length: 1847
• Species: Drosophila melanogaster
• Sequence 2: NP_492775.2
• Gene: lam-3 / 172952
• WormBaseID: WBGene00002248
• Length: 3102
• Species: Caenorhabditis elegans
• Alignment Length: 875
• Identity: 184/875 - (21%)
• Similarity: 305/875 - (34%)
• Gaps: 227/875 - (25%)

  Fly   164 LRYNLGGGAQIITVGRELHDGH------------WHKVQVLRNDEQTSLIVDGVSQQRSTKGKEF 216
            :.:::|.|.::||      :.|            |:.:.|||.....:|.|
 Worm  2328 VHWDIGSGKKMIT------NSHPINYVPSNDRVTWYHIDVLRIGNAVNLTV-------------- 2372

  Fly   217 QFGKFASNSDVYVGGMPNWYSSKLALLALPSVIFEPR------FRGAIR--NLVYADQPGGSTRR 273
                  :..:.|.||                  |:||      |.|..:  |.::...||.:|.
 Worm  2373 ------ALKESYDGG------------------FKPRGAPVSVFVGNSKDDNSIFNTIPGETTI- 2412

  Fly   274 QEIKQQRDIKCGDVPCDH---GELPARERPLRGVRGGNTTDACERNDPCQHGGICISTDSGPICE 335
                        ||..|.   .::........|:.||                  :..|..|: .
 Worm  2413 ------------DVGTDETVASDIGLTTHKFSGIVGG------------------LRIDEVPL-P 2446

  Fly   336 CRNLEYDGQYCEKEKAPSEATFRGTQFLSYDLGQTGAEPIVS--AQDAISFYFRTRQPNGLLFYT 398
            ..:.|.....||...:|.:.:.||..|..   |.......||  ...||:..|....|||||::.
 Worm  2447 LWSFESTTGECEGATSPPKTSQRGHLFRD---GFANVSMSVSERTMSAITVIFNAFSPNGLLYFR 2508

  Fly   399 GH--GTDYLNLALRDGGVSLTMGLANGK-QEMHIKPSKVRFDDHQWHKVTVHRRIQEISSITSFC 460
            |.  ..|::.:.|.||.|...:.|..|. .|:   .|:..::|.:.|.|...|...|:
 Worm  2509 GSEASGDFVAIYLNDGKVMFKINLGGGSVAEL---TSQNVYNDGKEHTVKAIRTGSEM------- 2563

  Fly   461 RLVTVVDDVYTDHSHIAGKFTMLS--SSRVYVGG---AVNPRALLGARVHTNFVGCLRKVEFSAD 520
             .:.|..|....::.|.|:.|.|:  :...||.|   .:| :.:.|......|:||:..|: .:.
 Worm  2564 -YLQVDSDADRFNTVITGENTALNIENENHYVAGVPMTLN-KEVFGDINWNGFIGCILTVK-PSQ 2625

  Fly   521 TLNLNLIDLAKSGSK---LIQVAGNLEYQCPSGDPQDPVTFTTRESHLVLPPWETGKQSSISFKF 582
            ...|:|.....|..|   ..||:|          ..|.:....:..:|:.........|:.:|.|
 Worm  2626 VGELDLDHPEHSQGKTDGCSQVSG----------VTDKIIGFPKPGYLITKGISIDNSSTFAFSF 2680

  Fly   583 RTKEPNGIIVLATGSKQPRAKNPV------LIAIELLNGHIYIHLDLGSGASKVRASRRRV---- 637
            ||:|.||.:|..:...|..:|...      .||..|..|::.:|  .|..||    ||:.|
 Worm  2681 RTREENGTLVYQSSKLQKVSKRDSEDDGKGYIAFYLFRGYLVLH--FGKDAS----SRKEVVTFR 2739

  Fly   638 -----DDGDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTILE-------LDGHMYLGG----VG 686
                 :||..|.:.:.|||:...|.||.     :..||...|.       ..|.:.|||    :.
 Worm  2740 SSHPYNDGQVHAVFMERNGKIISVKVDD-----KEIGDSQSLSDETSVGTTSGRLILGGFSDDLK 2799

  Fly   687 PAYNSVSWPAAIWTATLRQGFVGCLRDLVLSGKAIDIA--------AFARVQDSASVKP-SCHVQ 742
            |..|.:         .:...|:||:.|:.|:.|.:.:|        ....:.|:..:.| ...:.
 Worm  2800 PPNNEI---------PITSFFIGCISDVFLNMKRVSLAPEKHNAQIGMCSMDDTQGLSPIDDPID 2855

  Fly   743 ANVCNGNPCLNGGTCLEGWNR---PICDCSATLYGGP--------TCGRELATL------AFNGS 790
            .|..||:. .:.....|..||   .:...|:.|...|        ||...|.:|      ..:.|
 Worm  2856 GNGHNGHR-KSSKLSFEATNRNYYEVSTQSSHLVMNPNGEETVEKTCETSLGSLQGAVRYGLSKS 2919

  Fly   791 QHMTIWLGNGQGTKTQTEELVIR--FKTSRPAGLLLLTSAESNSPDRLEIALVAGRVRASVRLSD 853
            .|..|   |.:.......:..::  .:|....|::...:...|....:.:.::.|.....|:...
 Worm  2920 SHSRI---NFEAPYPNITDFTVKLSLQTETSNGMIWAWANYKNYTRYIFLDIIDGFATLEVKGHK 2981

  Fly   854 REKNLLAGQSVLNDNNWHTIRFSRRASNLRLQVDGAPPVRGMLSETILGRHSTMEIRSVHLGGLF 918
            :.|.|....:.:||..||.|...::..:|:|.:|...||    ..|.......|:.| |::||:.
 Worm  2982 QPKILKHLGNRINDGQWHDITVEKKNRSLKLIIDSLGPV----EMTDCPTPKVMKKR-VYVGGVI 3041

  Fly   919 HAEEEIQMTSTMPNFVG-----QMQGLVFN 943
             :....|...|.|...|     :|...:||
 Worm  3042 -SRHRRQFGLTTPGLDGCIRDFEMNNRIFN 3070

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058	20/118 (17%)
		EGF_CA	311..347	CDD:238011	3/35 (9%)
		Laminin_G_2	386..517	CDD:280389	36/138 (26%)
		LamG	555..716	CDD:238058	45/186 (24%)
		EGF	746..777	CDD:278437	8/41 (20%)
		Laminin_G_2	814..945	CDD:280389	30/135 (22%)
		LamG	988..1136	CDD:238058
		EGF	1164..1195	CDD:278437
		Laminin_G_2	1233..1356	CDD:280389
lam-3	NP_492775.2	LamNT	42..294	CDD:214532
		EGF_Lam	296..343	CDD:238012
		EGF_Lam	<384..411	CDD:214543
		Laminin_EGF	423..480	CDD:278482
		EGF_Lam	477..526	CDD:238012
		LamB	583..711	CDD:214597
		EGF_Lam	774..818	CDD:238012
		Laminin_EGF	889..943	CDD:278482
		EGF_Lam	941..985	CDD:214543
		EGF_Lam	988..1033	CDD:214543
		EGF_Lam	1036..1083	CDD:214543
		Laminin_EGF	1086..1134	CDD:278482
		EGF_Lam	1133..1179	CDD:238012
		Laminin_EGF	1181..1229	CDD:278482
		Laminin_EGF	1227..1281	CDD:278482
		LamB	1341..1478	CDD:214597
		EGF_Lam	1539..1583	CDD:238012
		EGF_Lam	1590..1637	CDD:214543
		EGF_Lam	1646..1694	CDD:238012
		BAR	1848..2058	CDD:299863
		PspA	1864..2121	CDD:224755
		Laminin_II	2157..2286	CDD:283628
		LamG	2285..2443	CDD:214598	30/189 (16%)
		LamG	2471..2622	CDD:238058	41/165 (25%)
		LamG	2655..2821	CDD:238058	45/185 (24%)
		LamG	2919..3065	CDD:238058	31/154 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910