DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-1 and itx-1

DIOPT Version :9

Sequence 1:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster
Sequence 2:	NP_001249244.2	Gene:	itx-1 / 171846	WormBaseID:	WBGene00002174	Length:	1645	Species:	Caenorhabditis elegans

Alignment Length:	1375	Identity:	269/1375 - (19%)
Similarity:	490/1375 - (35%)	Gaps:	388/1375 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 NSFYTFRKWYTGLN-GTLELEFK---TEQPNGLVLYTDDGGTYDFFELKLVEGALRLRYNLGGGA 172
            :::..::.|....: ..|.::|:   ::...|:::|.:..           :|.:...|.:|...
Worm   254 SAYLRYKPWEMDSHFSRLSMDFRFSDSDAKEGILVYGETS-----------QGKIFKIYVVGTKG 307

  Fly   173 QII-----TVGRELHDGH--WHKVQVLRNDEQTSLIVDGVSQQRSTKGKE------FQFGK---- 220
            :::     ....||.:.|  :|.:.|...|...:::||....:|:....:      .|||.
Worm   308 KVMLDTTNVADFELREDHSIFHSIIVKIVDGIFNMLVDDNVHRRAFNESDALVFDTIQFGAPIPT 372

  Fly   221 -------FASNSDVYVGGMPNWYSSKLALLALPSVIFEPRFRGAIRNLVYADQPGGSTRRQE--- 275
                   .|...:|||..:.   ..:||:|...|.....|.| :..|....:..|.|....:
Worm   373 DVSEVGVTACVKNVYVDHVD---IIELAVLTNDSRTTASRVR-SCNNEDLTEFQGPSLFSADPLA 433

  Fly   276 ---IKQQRDIKC--GD--VPCDHGELPARERPLRGVRGGNTTDACERNDP--CQHGGIC-ISTDS 330
               ::...|||.  |:  :..|...:|:.::|..     ....:||:.:.  ||:|..| ..:::
Worm   434 EILVEDPSDIKSEFGESVIGADMFPVPSNKKPKT-----QPLSSCEKANAYMCQNGAGCKKESET 493

  Fly   331 GPICECRNLEYDGQYCEKEKAPSEATFRGTQFLSYDLGQTGAE---------PIVSAQDAISFYF 386
            ...|.|:. .|.|::|:....|.... ....||....|.|..:         .:....|.
Worm   494 EFTCFCKE-GYIGKFCQFTTIPRSCA-EAYDFLKLPNGATWVDVDGNRKLDPSVTMCTDG----- 551

  Fly   387 RTRQPNGLL-FYTGHGTDYLN-----LALRD-------------GGVSLTMGLANGKQEMHIKPS 432
            :|..|:.:. .|....|.|.|     |:.||             |..|.|:.....|..:..|..
Worm   552 QTEIPHDMKPGYVVRDTTYQNHSLFVLSYRDFNSWQLAKYIKNSGSCSQTVNYRCNKAPLRFKEG 616

  Fly   433 KVRFDDHQWHKVTVH--RRIQEISSITSFCRLVTVVDDVYTDHSHIAGKFTMLSSSRVYVGGAVN 495
            |.      |.|...:  .:|::|..:.:.|..:        |....:|:.....|      ||:
Worm   617 KT------WFKSVSNATEKIKQIGMLPNSCPCL--------DRGCQSGEKCNCDS------GAI- 660

  Fly   496 PRALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQCPSGDPQDPVTFTT 560
                      :..:|.|.. .:|.....:.|.|.|...:::.    ..|.:|...:.:.|:.||.
Worm   661 ----------SEDIGELTG-RYSGICEVVTLFDEADVRAEMT----ISELKCSGYENEKPIRFTE 710

  Fly   561 RESHLVLPPWETGKQSSISFKFRTKEPNGIIVLATGSKQPRAKNPVLIAIELLNGHIYIHLDLGS 625
            | :.|.:..| ||:  ||..:|||.|....:|...|:...:     :|::.|.:||. :.:. ..
Worm   711 R-TELKISDW-TGE--SIDLQFRTTETPASLVTVQGNYGEK-----IISVSLTDGHT-VQIS-NF 764

  Fly   626 GASKVRASRRRVDDGDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTILELDGHMYLGGVGPAYN 690
            .|.|:..|:.:::|.:||.:::.....:.:|:||.. :...|.||..:||  |.:.|||.|
Worm   765 EALKIIESQTKLNDSNWHHVLIELADGEIRVTVDAT-HVLMTIGDNAVLE--GSVVLGGEG---- 822

  Fly   691 SVSWPAAIWTATLRQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSCHVQANVCNGNPCLNGG 755
                          .|.:||:|:::::.:.:::....:..:...:..:|..:   |..:.|.||.
Worm   823 --------------DGLIGCVRNVLINDEPVNLQEIVKTSEKTGITETCDTR---CTADFCQNGA 870

  Fly   756 TCLEGW--NRPICDCS-ATLYGGPTCGRELAT---LAFNGSQHMTIWLGNGQGTKTQTEELVIRF 814
            .|.|.:  ..|.|.|: ..::.|..|..::.|   ::|:|.     :|............:...|
Worm   871 KCYEDFVSGMPFCQCAFPDVHSGVNCEIDINTNSSVSFHGG-----YLKFDDVKNVLNAPIYFSF 930

  Fly   815 KTSRPAGLLLLTSAESNSPDRLEIALVAGRVRASVRLSDREKNLLAGQSVL--------NDNNWH 871
            :|.|...||.....::|  :.|::.| :..|..::.|::.:   :..|..:        .|..|.
Worm   931 RTDRTHALLFFAHDQNN--NFLQVHL-SEEVNVTLTLNNLD---IVSQCTVRAQPGTEYGDMRWI 989

  Fly   872 TIRFSRRASNLRLQVDGAPPVRGMLSETILGRHSTMEIRSVHLGGLFHAEEEIQMTSTMPNFVGQ 936
            .:..:..:.:.:||||.|       :.||    .|..:.|           ||.:|
Worm   990 QVAITHDSKSSQLQVDDA-------ACTI----RTSRVLS-----------EIPIT--------- 1023

  Fly   937 MQGLVFNGQRYLDIVKSLGPELSALPSATFKLTARFVNSPAGQPYHAATFRSKHSYVGLAMLKAY 1001
                     |.||:..|   ||..:|                              ||||
Worm  1024 ---------RLLDVYNS---ELVGMP------------------------------VGLA----- 1041

  Fly  1002 NSISIDFRFKTVEPNGLLVFNGGRRNDFVAVELVNGHIHYTFDLGDGPVTMRDKSRIHMNDNR-- 1064
                     ..|:||                       .|||.. .|.|...:|:    |..|
Worm  1042 ---------APVKPN-----------------------PYTFTF-IGNVNTGEKT----NGKRLL 1069

  Fly  1065 WHQVSIRRPGPKTHTLTV--DDSFEIISLTGNNMHLELAGILYIGGVFKDMY-SKLPASISSRSG 1126
            :.....||..|....:.:  |.||                      :....| |.:|.......|
Worm  1070 FSDCLPRRRSPSIFLMLIFPDGSF----------------------ILAPKYESPIPRFYGCIRG 1112

  Fly  1127 FEGCLASLDLGDASPSLTSDAVVPS---SLVVSGCEGPTKCSQNACANRGNCVQQW-------NA 1181
            |:.....:|:.:.:..|.:..:..:   :||..|||  ..||...|.|.|:|...|       ..
Worm  1113 FQINREMIDMREKTEHLATSEMYEAYGPALVKVGCE--VGCSSITCLNGGHCSVAWANTDPSAAT 1175

  Fly  1182 YACECDMTSYTGPTC-YDESI------AYEFGNNKGMVQYTFPENAQADTEEDNIALGFITTRPD 1239
            ..|:|..|||||.:| .||.:      ..||..:|.|.:|.|.|.   :::...:.....::.|:
Worm  1176 TTCDCSRTSYTGASCSLDEGVHMERSGFIEFDISKEMARYVFIEQ---NSKIPQLLKFAFSSSPE 1237

  Fly  1240 AVL-----LRVESATTQDYMELEIVEG---NIFMVYNIGSVDLPLGEIGTKVNDNAYHVVRFQRK 1296
            .||     |.:.....:..:|:||...   |:.:.|..|..|: |..:|..: |...|.|..|..
Worm  1238 IVLKDKSMLALVVFREKQKLEIEINPNRTINVAITYENGKSDV-LNFVGDFL-DGYRHFVVVQTN 1300

  Fly  1297 GGNAT-LQLD----DYNVQALTPQSHHSTVFNTMSNVQVGGKFSRNGRNR-------IERPFAGV 1349
            ..:|| :.:|    |:..:.   :..:..:||. ..:::||    ..|:|       ::..:.|.
Worm  1301 QASATAVMIDSLRQDFEYRG---KDKNIDLFNA-ERIRIGG----GPRDRYTETDGYLKAGYTGC 1357

  Fly  1350 IAGLSVNKLR 1359
            |:...|:..|
Worm  1358 ISNFIVDYQR 1367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058	31/178 (17%)
		EGF_CA	311..347	CDD:238011	10/38 (26%)
		Laminin_G_2	386..517	CDD:280389	27/151 (18%)
		LamG	555..716	CDD:238058	43/160 (27%)
		EGF	746..777	CDD:278437	10/33 (30%)
		Laminin_G_2	814..945	CDD:280389	25/138 (18%)
		LamG	988..1136	CDD:238058	26/152 (17%)
		EGF	1164..1195	CDD:278437	14/37 (38%)
		Laminin_G_2	1233..1356	CDD:280389	29/142 (20%)
itx-1	NP_001249244.2	LamG	254..389	CDD:238058	23/145 (16%)
		EGF	481..507	CDD:278437	8/26 (31%)
		LamG	705..835	CDD:238058	43/161 (27%)
		LamG	905..1052	CDD:238058	44/267 (16%)
		LamG	<1268..1364	CDD:304605	22/105 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910