Protein Alignment Nrx-1 and AgaP_AGAP007545

DIOPT Version :9

• Sequence 1: NP_001262840.1
• Gene: Nrx-1 / 42646
• FlyBaseID: FBgn0038975
• Length: 1847
• Species: Drosophila melanogaster
• Sequence 2: XP_308333.4
• Gene: AgaP_AGAP007545 / 1269688
• VectorBaseID: AGAP007545
• Length: 1245
• Species: Anopheles gambiae
• Alignment Length: 1126
• Identity: 286/1126 - (25%)
• Similarity: 446/1126 - (39%)
• Gaps: 254/1126 - (22%)

  Fly   357 FRGTQFLSYDLGQTGAEPIVSAQDAISFYFRTRQPNGLLFYTGHGT--DYLNLALRDGGVSLTMG 419
            |.||..:.|||.:   :||.:.:::|.|.|:|..|||:|.|: .||  ||..|.::|..:.|.:.
Mosquito   155 FNGTGLVRYDLLR---DPIAATRESIRFRFKTAHPNGVLLYS-RGTQGDYFALQIKDNRMVLNVD 215

  Fly   420 LANGKQEMHIKPSKVRFDDHQWHKVTVHRRIQEISSITSFCRLVTVVDDVYTDHSHIAGKFTMLS 484
            |  |.:.|.........||:.||.|.:.|..::|  |.|..|::.        ...|.|:|..|:
Mosquito   216 L--GAKIMTSLSVGSLLDDNIWHDVVISRNRRDI--IFSVDRVIV--------QRRIKGEFDKLN 268

  Fly   485 SSR-VYVGGAVNPRALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQCP 548
            .:| .|:||.  |....|..:..||.||:..:.|:|......:.|....|..|.....::.|.||
Mosquito   269 LNREFYIGGV--PNLQEGLVIQHNFTGCIENLHFNATNFIREMKDAFYDGEHLRYKMTHVTYNCP 331

  Fly   549 SGDPQDPVTFTTRESHLVLPPWETGKQSSISFKFRTKEPNGIIVLATGSKQPRAKNPVLIAIELL 613
            . .|.:||||.||.||..|..:.:.||.::||.|||.|..|:                ::..:.|
Mosquito   332 E-PPINPVTFLTRGSHAKLKGYYSSKQFNVSFAFRTYEEKGL----------------MLHHDFL 379

  Fly   614 NGHIYIHLDLGSGASKVRAS---------------RRRVDDGDWHDLILRRNGRDAKVSVDGVWN 663
            .|.:.:.|:  .|..|||..               ..:.:||:||.::|........:|:|.
Mosquito   380 QGSVQVFLE--EGKVKVRLKEDNYEHNPGTILDNYEEQFNDGNWHHMMLTIKKNSLVLSIDD--- 439

  Fly   664 DFRTPGDGTILELD---GHMYLGGVGPAYNSVSWPAAIWTATLRQGFVGCLRDLVLSG------- 718
               .|.:.|.| :|   |.:|..|.|..               :.|||||:|...:.|
Mosquito   440 ---RPMETTKL-IDITTGTLYYIGGGKT---------------KDGFVGCMRSFAIDGNYRIPTD 485

  Fly   719 -KAIDIAAFARVQDSASVKPSCHVQANVCNGNPCLNGGTCLEGWNRPICDCSATLYGGPTCGREL 782
             |..:......:...|     ||: .:.||.|||.:.|.|.:......|||:.|.|.|..|...:
Mosquito   486 WKEEEYCCKGEILFDA-----CHM-VDRCNPNPCKHSGICKQNSMEFTCDCAGTGYAGAVCHTPM 544

  Fly   783 ATLAFNGSQHMTIWLGNGQGTKTQTEELVIRFKTSRPAGLLLLTSAESNSPDRLEIALV-----A 842
            ..|:....:       |....| |.:.:.|....|.|.....:| .|..|..|:...|.     .
Mosquito   545 NALSCQAFK-------NVHDVK-QRQRIEIDVDGSGPLAPFPVT-CEFYSDGRVVTVLSHSSEHT 600

  Fly   843 GRVRASVRLSDREKNLLAG------QSVLNDNN--WHTIRFSRRASNL----------------- 882
            .||.........|:|::..      :::||.:.  |.|:.::.|:|.|
Mosquito   601 TRVDGFAEPGSFEQNIIYEADLPQIEALLNRSTECWQTLTYACRSSRLFNSPSDPENFRPYAWWV 665

  Fly   883 ---RLQVD---GAPPVRGMLSETILG------RHSTMEIRSVHL---GGLFHAEEEIQMTSTMPN 932
               ...:|   ||.|........::|      :....:..|:..   ||      :|:....:|
Mosquito   666 SRHNQPMDYWAGALPGSRKCQCGVVGDCIDPTKWCNCDANSLDWQEDGG------DIREKEYLP- 723

  Fly   933 FVGQMQGLVFNGQ---------RYLDIVKSLGPELSALPSATFKLTARFVNSPAGQPYHAATFRS 988
                ::||.|...         ||     :||| |.....:.|.              :..|||.
Mosquito   724 ----VRGLRFGDTGTPVDEKLGRY-----TLGP-LRCSGDSLFN--------------NEVTFRI 764

  Fly   989 KHSYVGLAMLKAYNSISIDFRFKTVEPNGLLVFNGGRRNDFVAVELVNG-HIHYTFDLGDGP--- 1049
            ..:.:.|......:|..|.|.|||...|.:|:...| ..||:.:::|.| .:.:.:..|.|.
Mosquito   765 ADATIDLPPFDMGHSGDIYFEFKTTIENAVLLHARG-PTDFIRLDIVGGTKLLFEYQAGTGTQKV 828

  Fly  1050 -VTMRDKSRIHMNDNRWHQVSIRRPGPKTHTLTVDDS--FEIISLTGNNMHLELAGILYIGGVFK 1111
             |.|.:|    :||:|||.||:.| ..|...|.||.|  .|:....|....|.|...|.||
Mosquito   829 YVEMSNK----LNDDRWHSVSVER-NRKEARLVVDGSTKAEVREPPGPVRALHLNSTLTIG---- 884

  Fly  1112 DMYSKLPASISSRSGFEGCLASLDLGDASPSLTSDAVVPSSLVVSGCEGPTKCSQNACANRGNCV 1176
                   |.:..|.|:.||:.:|.|......|.|.|......|..||.|  :|..:.|.|.|.|.
Mosquito   885 -------ARLDYRDGYVGCIRALLLNGEPVDLRSYAERGLYGVSVGCVG--RCESSPCLNNGTCT 940

  Fly  1177 QQWNAYACECDMTSYTGPTCYDESIAYEFGNN---KGMVQYTFPENAQADTEEDNIALGFITTRP 1238
            ::::.:.|:|..:|:.||.|.|     |.|.|   ..|::|.| :.|...|..:.|.:||.||.|
Mosquito   941 ERYDGFTCDCRWSSFKGPICAD-----EIGVNMRSSSMIKYDF-QGAFRSTLSERIRVGFTTTNP 999

  Fly  1239 DAVLLRVESATTQDYMELEIV-EGNIFMVYNIG----SVDLPLGEIGTKVNDNAYHVVRFQRK-- 1296
            ...|:.:.|..||:|:.|.:. .|::.:|::.|    .:..|:...|.    ..||.|||.||
Mosquito  1000 KGFLIGLFSNITQEYLTLMVSNSGHLKVVFDFGFERQELIYPVKHFGL----GQYHDVRFSRKNS 1060

  Fly  1297 GGNATLQLDDYNVQALTPQSHHSTV-------FNTMSNVQVGGKFS-RNGRNRIERPFAGVIAGL 1353
            |....|.:|:|.     ||.:|..:       ||.:..:.:|...| ::|       |.|.|:.:
Mosquito  1061 GSTVVLSVDNYE-----PQEYHFDIKGSADAQFNNVEYMYIGKNESMKDG-------FVGCISRV 1113

  Fly  1354 SVNKLRILDLAVERDPHITIR 1374
            ..:.:..|....:.:|...:|
Mosquito  1114 EFDDIYPLKFLFQENPPPNVR 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058
		EGF_CA	311..347	CDD:238011
		Laminin_G_2	386..517	CDD:280389	41/133 (31%)
		LamG	555..716	CDD:238058	46/178 (26%)
		EGF	746..777	CDD:278437	13/30 (43%)
		Laminin_G_2	814..945	CDD:280389	31/175 (18%)
		LamG	988..1136	CDD:238058	45/154 (29%)
		EGF	1164..1195	CDD:278437	9/30 (30%)
		Laminin_G_2	1233..1356	CDD:280389	37/137 (27%)
AgaP_AGAP007545	XP_308333.4	FA58C	7..146	CDD:214572
		FA58C	18..145	CDD:238014
		LamG	152..301	CDD:238058	51/163 (31%)
		LamG	337..477	CDD:238058	46/179 (26%)
		EGF	508..537	CDD:278437	12/28 (43%)
		LamG	772..903	CDD:238058	44/147 (30%)
		EGF_CA	928..960	CDD:238011	10/31 (32%)
		Laminin_G_2	994..1118	CDD:280389	37/139 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D7752at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920