DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrx-1 and Lamc1

DIOPT Version :9

Sequence 1:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster
Sequence 2:	NP_446418.1	Gene:	Lamc1 / 117036	RGDID:	621052	Length:	1607	Species:	Rattus norvegicus

Alignment Length:	808	Identity:	161/808 - (19%)
Similarity:	240/808 - (29%)	Gaps:	292/808 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 TLSAGFQLDGSQNSFYTFRKWYTGLNGTL-----------ELEFKTEQPNGLVLY---TDDGG-- 148
            |:.||.|...|             :|.||           .|:|.|.:|....:|   .:||.
  Rat   120 TMLAGVQYPNS-------------INLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWI 171

  Fly   149 TYDFFELKLVEGALRLRYNLGGGAQIITVGRELHDGHWHKVQVLRNDEQTSLIVDGVSQQRSTKG 213
            .|.::     .|:....|:......|.|.|                |||.:|..|..|......|
  Rat   172 PYQYY-----SGSCENTYSKANRGFIRTGG----------------DEQQALCTDEFSDISPLTG 215

  Fly   214 KEFQFGKFA--------SNSDVYVGGMPNWYSS---KLALLAL----PSVIFEPRFRGAIRNLVY 263
            ....|....        .||.|    :..|.::   ::.|..|    ..|..:|:   .:::..|
  Rat   216 GNVAFSTLEGRPSAYNFDNSPV----LQEWVTATDIRVTLNRLNTFGDEVFNDPK---VLKSYYY 273

  Fly   264 ADQP---GGSTR-----RQEIKQQ-RDIKCGDVPCDHGE--------LP-ARERPLR--GVRGGN 308
            |...   ||..:     .:.:|.: ..:.|.   |.|..        || ..:||.|  .....|
  Rat   274 AISDFAVGGRCKCNGHASECVKNEFGKLVCN---CKHNTYGVDCEKCLPFFNDRPWRRATAESAN 335

  Fly   309 TTDACERNDPCQ-------------HGGICISTDSGPICECRNLEYDGQYCEKEKAPSEATFRGT 360
            ....|:.|...|             |||.|.:        ||: ..||..||:.:   |..||
  Rat   336 QCLPCDCNGRSQECYFDPELYRSTGHGGHCTN--------CRD-NTDGAKCERCR---ENFFR-- 386

  Fly   361 QFLSYDLGQTGA------EPIVSAQDAISFYFRTRQPNGLLFYTGHGTDYLNLALRDGGVSLTMG 419
                  ||.|.|      .|:.|.......|.|.....|::   |...|    ..:.|..|||
  Rat   387 ------LGNTEACSPCHCSPVGSLSTQCDSYGRCSCKPGVM---GDKCD----RCQPGFHSLT-- 436

  Fly   420 LANGKQEMHIKPSKVRFDDHQWHKVTVHRRIQEISSITSFCRLVT----VVDDV--YTDHSHIAG 478
                  |...:|...                 :.|..|..|.:.|    ..|:|  ::......|
  Rat   437 ------EAGCRPCSC-----------------DPSGSTDECNVETGRCVCKDNVEGFSCERCKPG 478

  Fly   479 KFTMLSSSRVYVGGAVNPRALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKLIQVAG-- 541
            .|.:.||         ||:.........:...|...|.:|...:: :...:.:.|.::.|..|
  Rat   479 FFNLESS---------NPKGCTPCFCFGHSSVCTNAVGYSVYDIS-STFQIDEDGWRVEQRDGSE 533

  Fly   542 -NLEYQCPSGDPQD--PVTFTTRESHLVLPPWETGKQ-----SSISFKFRTK------------- 585
             :||:   |.|.||  .::.|....:.|.|....|.|     .::||.||..
  Rat   534 ASLEW---SSDRQDIAVISDTYFPRYFVAPAKFLGNQVLSYGQNLSFSFRVDRRDTRLSAEDLVL 595

  Fly   586 EPNGIIV----LATGSKQPRAK----------------NPVLIAIE---LLNGHIYIHLDLGSGA 627
            |..|:.|    :|.|:..|...                .|.|...|   |||....|
  Rat   596 EGAGLRVSVPLIAQGNSYPSETTVKYIFRLHEATDYPWRPALSPFEFQKLLNNLTSI-------- 652

  Fly   628 SKVRASRRRVDDGDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTILELDGHMYLGGVGPAYNSV 692
             |:|.:......|...|:.|:.                ..||.|.              ||
  Rat   653 -KIRGTYSERSAGYLDDVTLQS----------------ARPGPGV--------------PA---- 682

  Fly   693 SWPAAIWTATLRQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSCHVQANVCNG-----NPCL 752
            :|   :.:.|...|:.|...:..|.|..         :::.|:.|........|||     :|..
  Rat   683 TW---VESCTCPVGYGGQFCETCLPGYR---------RETPSLGPYSPCVLCTCNGHSETCDPET 735

  Fly   753 NGGTCLEGWNRPICD-CSATLYGGPTCG 779
            ....|.:....|.|: ||...||..|.|
  Rat   736 GVCDCRDNTAGPHCEKCSDGYYGDSTLG 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058	33/183 (18%)
		EGF_CA	311..347	CDD:238011	11/48 (23%)
		Laminin_G_2	386..517	CDD:280389	24/136 (18%)
		LamG	555..716	CDD:238058	36/201 (18%)
		EGF	746..777	CDD:278437	11/36 (31%)
		Laminin_G_2	814..945	CDD:280389
		LamG	988..1136	CDD:238058
		EGF	1164..1195	CDD:278437
		Laminin_G_2	1233..1356	CDD:280389
Lamc1	NP_446418.1	LamNT	42..282	CDD:214532	39/202 (19%)
		EGF_Lam	283..328	CDD:238012	8/47 (17%)
		Laminin_EGF	340..394	CDD:278482	20/73 (27%)
		Laminin_EGF	396..443	CDD:278482	12/61 (20%)
		Laminin_EGF	443..490	CDD:278482	12/72 (17%)
		LamB	552..676	CDD:214597	26/148 (18%)
		Laminin_EGF	722..761	CDD:278482	11/38 (29%)
		EGF_Lam	770..818	CDD:238012
		Laminin_EGF	826..873	CDD:278482
		Laminin_EGF	882..930	CDD:278482
		EGF_Lam	933..978	CDD:214543
		EGF_Lam	980..1027	CDD:238012
		FlgN	<1048..1121	CDD:298847
		MA	1089..1300	CDD:214599
		Tropomyosin	1355..1586	CDD:278679
		Prefoldin	1416..1551	CDD:298833
		SPX	<1518..1588	CDD:271919
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910