DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nrx-1 and Nrxn2

DIOPT Version :9

Sequence 1:NP_001262840.1 Gene:Nrx-1 / 42646 FlyBaseID:FBgn0038975 Length:1847 Species:Drosophila melanogaster
Sequence 2:XP_017444150.1 Gene:Nrxn2 / 116595 RGDID:620211 Length:1715 Species:Rattus norvegicus


Alignment Length:1883 Identity:597/1883 - (31%)
Similarity:877/1883 - (46%) Gaps:390/1883 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 RRRRSEQVPPVVVEYRRSYRVLIVSALLVSLAASFVTLSAGFQLDGSQNSFYTFRKWYTGLNGTL 128
            |.|...|:||::              ||::|.|..    .|.:..|....:..:.:| .|...|.
  Rat     6 RWRPPPQLPPLL--------------LLLALVAGV----RGLEFGGGPGQWARYARW-AGAASTG 51

  Fly   129 ELEF--KTEQPNGLVLYTDDGGTYDFFELKLVEGALRLRYNLG-GGAQIITVGRELHDGHWHKVQ 190
            ||.|  :|.....|:||.||||..||.||.||:|.||||:.|. .....:.:...:.|..||.|.
  Rat    52 ELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVL 116

  Fly   191 VLRNDEQTSLIVDGVSQQRSTKGK--EFQFGKFASNSDVYVGGMPNWYSSKLALLALPSVIFEPR 253
            :.|:..:|:|.|||.::....:.|  |.|..     ||::|||:|.  ..:|:.|.|.:|.:||.
  Rat   117 LTRDARRTALAVDGEARAAEVRSKRREMQVA-----SDLFVGGIPP--DVRLSALTLSTVKYEPP 174

  Fly   254 FRGAIRNLVYADQPGGSTRRQEIKQQRDIKCGDVPCDHGELPARERPLRGVRGGNTTDAC--ERN 316
            |||.:.||...::|                    |...|.        :|:||......|  .||
  Rat   175 FRGLLANLKLGERP--------------------PALLGS--------QGLRGAAADPLCAPARN 211

  Fly   317 DPCQHGGICISTDSGPI-CECRNLEYDGQYCEKEKAPSE-------------------------- 354
             ||.:||:|.....|.: |:|.:..:.|::|.:|:.|.|                          
  Rat   212 -PCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGA 275

  Fly   355 --------------ATFRGTQFLSYDLGQTGAEPIVSAQDAISFYFRTRQPNGLLFYTGHGTDYL 405
                          |||:|.:|..|||..   .||.|:.|.|:..|||.|.|||:.:||...||:
  Rat   276 GDVHQPTKGKEEFVATFKGNEFFCYDLSH---NPIQSSTDEITLAFRTLQRNGLMLHTGKSADYV 337

  Fly   406 NLALRDGGVSLTMGLANGKQEMHIKPSKVRFDDHQWHKVTVHRRIQEISSI-----TSFCRLVTV 465
            ||:|:.|.|.|.:.|.:|..|..::|...:|:|:.||.|.|.|.:::.:.|     .....|||:
  Rat   338 NLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTI 402

  Fly   466 -VDDVYTDHSHIAGKFTMLSSSR-VYVGGAVNPRALLGARVHTNFVGCLRKVEFSADTLNLNLID 528
             ||.:.|...:....:|||.|.. .|:||:.|...|.|:.|..||:|||:.|.:..:...|.|..
  Rat   403 SVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSR 467

  Fly   529 LAKSGSKLIQVAGNLEYQCPSGDPQDPVTFTTRESHLVLPPWETGKQSSISFKFRTKEPNGIIVL 593
            |||.|...:::.|:|.::|......|||||.:.|:.:.||.|...:..|||..|||.||||:::.
  Rat   468 LAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLF 532

  Fly   594 ATG----------SKQPRAKNPVLIAIELLNGHIYIHLDLGSGASKVRASRRRVDDGDWHDLILR 648
            :.|          |...||.   ..|:|||:|::|:.||:|||..|:|||.|:|:||:|..:..:
  Rat   533 SQGRRAGAGVGSHSSSQRAD---YFAMELLDGYLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQ 594

  Fly   649 RNGRDAKVSVDGVWNDFRTPGDGTILELDGHMYLGGVGPAYNSVS--WPAAIWTATLRQGFVGCL 711
            |:||...:||:.....|...|:..:|:|:..:||||: |....|.  .|..:|||.||.|:|||:
  Rat   595 RDGRKGSISVNSRSTPFLATGESEVLDLESELYLGGL-PEGGRVDLPLPPEVWTAALRAGYVGCV 658

  Fly   712 RDLVLSGKAIDIAAFARVQDSASVKPSCHVQA-NVCNGNPCLNGGTCLEGWNRPICDCSATLYGG 775
            |||.:.|::.|:...|..|.:..|.|.|..:. ..|...||.|||.|.|||||.:|||..|.:.|
  Rat   659 RDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGICREGWNRFVCDCIGTGFLG 723

  Fly   776 PTCGRELATLAFNGSQHMTIWLGNGQGTKTQTEELVIRFKTSRPAGLLLLTSAESNSPDRLEIAL 840
            ..|.||...|:::||.:|.|.|.|..  .|:.|::.:||.:.|..||::.|::. .|.|.|.:.|
  Rat   724 RVCEREATVLSYDGSMYMKIMLPNAM--HTEAEDVSLRFMSQRAYGLMMATTSR-ESADTLRLEL 785

  Fly   841 VAGRVRASVRL------------SDREKNLLAGQSVLNDNNWHTIRFSRRASNLRLQVDGAPPVR 893
            ..|:::.:|.|            ....:.|.||.. ||||.|||:|..||..:|:|.||.. .|.
  Rat   786 DGGQMKLTVNLDCLRVGCAPSAAGKGPETLFAGHK-LNDNEWHTVRVVRRGKSLQLSVDNV-TVE 848

  Fly   894 GMLSETILGRHSTMEIRSVHLGGLFHAEEEIQMTSTMP-NFVGQMQGLVFNGQRYLDIVKSLGPE 957
            |.::    |.|:.:|..::..|.:    .|.:..|.:| ||:|.:.|||||||.|:|..|.    
  Rat   849 GQMA----GAHTRLEFHNIETGIM----TERRFISVVPSNFIGHLSGLVFNGQPYMDQCKD---- 901

  Fly   958 LSALPSATF-KLTARF-VNSPAGQPYHAATFRSKHSYVGLAMLKAYNSISIDFRFKTVEPNGLLV 1020
                ...|: :|.||| :.:....|   .||:|:.||:.||.|:||.|:.:.|:|||..|:|||:
  Rat   902 ----GDITYCELNARFGLRAIVADP---VTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLL 959

  Fly  1021 FNGGRRNDFVAVELVNGHIHYTFDLGDGPVTMRDKSRIHMNDNRWHQVSIRRPGPKTHTLTVDDS 1085
            ||.|..|||:.:|||.|:|||.||||:||..|:..|...:|||:||.|.:.|.....|||.: ||
  Rat   960 FNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKI-DS 1023

  Fly  1086 FEIISLTGNNMHLELAGILYIGGVFKDMYSKLPASISSRSGFEGCLASLDLGDASPSLTSDAVVP 1150
            ..:...:....:|:|.|.|||||:.|:|:|.||..::||.||:|||||:||....|.|.:||:..
  Rat  1024 RTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHR 1088

  Fly  1151 SSLVVSGCEGP-TKCSQNACANRGNCVQQWNAYACECDMTSYTGPTCYDESIAYEFGNNKGMVQY 1214
            ...|..||:|| |.|::.:|||:|.|:|||:.:.|:|.||||.||.|.|....|.||....::.|
  Rat  1089 IGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITY 1153

  Fly  1215 TFPENAQADTEEDNIALGFITTRPDAVLLRVESAT-TQDYMELEIVEGNIFMVYNIGSVDLPLGE 1278
            |:|.|.:..|..|.:|:||.|.:..|||:||:||: ..||::|.|.:|.:.:::|:|:.|:.:.|
  Rat  1154 TWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDE 1218

  Fly  1279 IGTKVNDNAYHVVRFQRKGGNATLQLDDYNVQALTP----------------------------- 1314
            ....|:|..||||||.|.|||||||:|.:.|....|                             
  Rat  1219 PNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVDEWLL 1283

  Fly  1315 -QSHHSTVFNTMSNVQVGGKFSRNGRNRIERPFAGVIAGLSVNKLRILDLAVERDPHITIRGDVQ 1378
             :....|:||:.:.:::||:..       .|||.|.::||..|.|::|.||.|.||::...|.::
  Rat  1284 DKGRQLTIFNSQAAIKIGGRDQ-------GRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLR 1341

  Fly  1379 LV--------------TGVLDRNDLQRMQQTLNSTRQTPASGYPGAL--------DDLIFSGAGS 1421
            ||              |.:|.......|:.|......|...|....:        |||:.  |.:
  Rat  1342 LVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTMRDSTTQNTDDLLV--ASA 1404

  Fly  1422 GCRGDDED--ECTPPFESGSGDDLITPV----------------YVPP-------------TKQT 1455
            .|..||||  ||.|    .:|.:||.|:                :|||             |:.|
  Rat  1405 ECPSDDEDLEECEP----STGGELILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDT 1465

  Fly  1456 TTSQQGNSLSTGGSSSGGVITNGTERACDDEDC---VHGSGDYGETTEQFTSTSTARGSESNNEM 1517
            .........|:||...       .||  ||.||   |..||        |.|             
  Rat  1466 LPPPAARRPSSGGPCQ-------AER--DDSDCEEPVEASG--------FAS------------- 1500

  Fly  1518 VTITTTGRSDVTTEQHQGSSSSSSSGSTPSYATTQSSSSSSSGGSAASTPGQVSTTSSVATSSTQ 1582
                                                              |:|..:|...|....
  Rat  1501 --------------------------------------------------GEVFDSSLPPTDDED 1515

  Fly  1583 RATSSSTSTSSSTTSTTTTTTTTQATPPPEIRSTVTERETTPYDIYIAGGGMG---GSGRNDH-D 1643
            ..|     |....|..||..:..:..|.|.:|   |:..|....:.:|.....   .:|:.:| |
  Rat  1516 FYT-----TFPLVTDRTTLLSPRKPAPRPNLR---TDGATGAPGVLLAPSAPAPNLPAGKMNHRD 1572

  Fly  1644 RMQLPDEHHPL---PPLPPPIP----PQDPPPYGPYGGNTY--------NTNMNNYRPKGKGGRI 1693
            .:|      ||   |||.|.:|    |:.|||..|  |.|.        ..|......:|..|.:
  Rat  1573 PLQ------PLLENPPLGPGVPTAFEPRRPPPLRP--GVTSVPGFPRLPTANPTGPGERGPPGAV 1629

  Fly  1694 NSIEE--ERTAMIIGIVAGILIAVVLVILLVLWLKSNGDRG-YKTESEKAAAYGSHNPNAALL 1753
            ..|.|  ..|.|::||||...:. :|::|..::...|.|.| |:.:..:.....|...|.|::
  Rat  1630 EVIRESSSTTGMVVGIVAAAALC-ILILLYAMYKYRNRDEGSYQVDQSRNYISNSAQSNGAVV 1691

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nrx-1NP_001262840.1 LamG 110..263 CDD:238058 56/157 (36%)
EGF_CA 311..347 CDD:238011 12/38 (32%)
Laminin_G_2 386..517 CDD:280389 52/137 (38%)
LamG 555..716 CDD:238058 70/172 (41%)
EGF 746..777 CDD:278437 17/30 (57%)
Laminin_G_2 814..945 CDD:280389 46/143 (32%)
LamG 988..1136 CDD:238058 72/147 (49%)
EGF 1164..1195 CDD:278437 16/30 (53%)
Laminin_G_2 1233..1356 CDD:280389 48/153 (31%)
Nrxn2XP_017444150.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166340464
Domainoid 1 1.000 134 1.000 Domainoid score I4871
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 831 1.000 Inparanoid score I428
OMA 1 1.010 - - QHG46386
OrthoDB 1 1.010 - - D24127at33208
OrthoFinder 1 1.000 - - FOG0001168
OrthoInspector 1 1.000 - - otm46164
orthoMCL 1 0.900 - - OOG6_103392
Panther 1 1.100 - - LDO PTHR15036
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X794
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.910

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