DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-1 and Nrxn3

DIOPT Version :9

Sequence 1:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster
Sequence 2:	XP_038967552.1	Gene:	Nrxn3 / 116508	RGDID:	620212	Length:	1696	Species:	Rattus norvegicus

Alignment Length:	1854	Identity:	600/1854 - (32%)
Similarity:	907/1854 - (48%)	Gaps:	326/1854 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 LIVSALLVSLAASFVTLSAGFQLDGSQNSFYTFRKWYTGLNGTLELEFKTEQPNGLVLYTDDGGT 149
            |.||..|.||    |.|..|.:..|..|.:..:.:|.......|..:|||....||:||.||||.
  Rat    12 LKVSIFLGSL----VGLCLGLEFMGLPNQWARYLRWDASTRSDLSFQFKTNVSTGLLLYLDDGGV 72

  Fly   150 YDFFELKLVEGALRLRYNLGGGAQIITVGRELHDGHWHKVQVLRNDEQTSLIVDGVSQQRSTKGK 214
            .||..|.||:|.::||:::......:...::::|..||.:.|.|:..:|.|::||
  Rat    73 CDFLCLSLVDGRVQLRFSMDCAETTVLSNKQVNDSSWHFLMVSRDRVRTGLVIDG---------- 127

  Fly   215 EFQFGKFASN-------SDVYVGGMPNWYSSKLALLALPSVIFEPRFRGAIRNLVYADQPGGSTR 272
            |.|.|:....       ||:::||:|  ...:.:.|.|..|...|.|:|.:.:|.|.:.......
  Rat   128 EGQSGELRPQRPYMDVVSDLFLGGVP--ADIRPSALTLDGVQNMPGFKGLMLDLKYGNSEPRLLG 190

  Fly   273 RQEIKQQRDIKCGDVPCDHGELPARERPLRGVRGGNTTDACERNDPCQHGGICISTDSGPICECR 337
            .|.::.:.:..||                            ||  ||::||||...|..|.|:|.
  Rat   191 SQSVQLEAEGPCG----------------------------ER--PCENGGICFLLDGHPTCDCS 225

  Fly   338 NLEYDGQYCEKE------------------KAPSE--ATFRGTQFLSYDLGQTGAEPIVSAQDAI 382
            ...|.|..|.::                  ||..|  |||||:::|.|||.|   .||.|:.|.|
  Rat   226 TTGYGGTLCSEDVSQGPGLSHLMMSEQGRSKAREENVATFRGSEYLCYDLSQ---NPIQSSSDEI 287

  Fly   383 SFYFRTRQPNGLLFYTGHGTDYLNLALRDGGVSLTMGLANGKQEMHIKPSKVRFDDHQWHKVTVH 447
            :..|:|.|.|||:.:||...||:||||:||.|||.:.|.:|..|..::|...:|:|:.||.|.|.
  Rat   288 TLSFKTWQRNGLILHTGKSADYVNLALKDGAVSLVINLGSGAFEAIVEPVNGKFNDNAWHDVKVT 352

  Fly   448 RRIQEISSITSFCRLVTV-VDDVYTDHSHIAGKFTMLSSSR-VYVGGAVNPRALLGARVHTNFVG 510
            |.:::.|.|..  .:||: ||.:.|...:....:|||.|.. .||||:.:...|.|:.|..||:|
  Rat   353 RNLRQHSGIGH--AMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMG 415

  Fly   511 CLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQCPSGDPQDPVTFTTRESHLVLPPWETGKQ 575
            ||::|.:..:.:.|.|..||:.|...:::.|.:.::|.:....||:.|.|.|:::.||.|.|.:.
  Rat   416 CLKEVVYKNNDIRLELSRLARIGDTKMKIYGEVVFKCENVATLDPINFETPEAYISLPKWNTKRM 480

  Fly   576 SSISFKFRTKEPNGIIVLATGSKQPR-----AKNPVL--IAIELLNGHIYIHLDLGSGASKVRAS 633
            .||||.|||.||||:|:...|..|.|     .||..:  .|:|||:|::|:.||:|||..||:|:
  Rat   481 GSISFDFRTTEPNGLILFTHGKPQERKDVRSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKAT 545

  Fly   634 RRRVDDGDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTILELDGHMYLGGVGPAYNSVSWPAAI 698
            :::.:||:|:.:.::|:||...:||:.....|...|:..||:|:|.|||||:......:..|..:
  Rat   546 QKKANDGEWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTEL 610

  Fly   699 WTATLRQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSC-HVQANVCNGNPCLNGGTCLEGWN 762
            |||.|..|:|||:|||.:.|::.:|...|.:|::|.||.|| .:.|..|:..||.|...|.:|||
  Rat   611 WTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWN 675

  Fly   763 RPICDCSATLYGGPTCGRELATLAFNGSQHMTIWLGNGQGTKTQTEELVIRFKTSRPAGLLLLTS 827
            |.||||:.|.|.|.||.||.:.|:::||.:|.:.:  .....|:.|::..||.:.|..|||:.|:
  Rat   676 RFICDCTGTGYWGRTCEREASILSYDGSMYMKVIM--PMVMHTEAEDVSFRFMSQRAYGLLVATT 738

  Fly   828 AESNSPDRLEIALVAGRVRASVRL---------SDREKNLLAGQSVLNDNNWHTIRFSRRASNLR 883
            :. :|.|.|.:.|..|||:..|.|         |...:.|.|||. ||||.|||:|..||..:|:
  Rat   739 SR-DSADTLRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQK-LNDNEWHTVRVVRRGKSLK 801

  Fly   884 LQVDGAPPVRGMLSETILGRHSTMEIRSVHLGGLFHAEEEIQMTSTMP-NFVGQMQGLVFNGQRY 947
            |.||.     .:...|::|.|:.:|..::..|.:    .|.:..|.:| :|:|.:|.|:|||..|
  Rat   802 LTVDD-----DVAEGTMVGDHTRLEFHNIETGIM----TEKRYISVVPSSFIGHLQSLMFNGLLY 857

  Fly   948 LDIVKSLGPELSALPSATFKLTARF-VNSPAGQPYHAATFRSKHSYVGLAMLKAYNSISIDFRFK 1011
            :|:.|:...:..       :|.||| :.:....|   .||::|.||:.||.|:||.|:.:.|:||
  Rat   858 IDLCKNGDIDYC-------ELKARFGLRNIIADP---VTFKTKSSYLTLATLQAYTSMHLFFQFK 912

  Fly  1012 TVEPNGLLVFNGGRRNDFVAVELVNGHIHYTFDLGDGPVTMRDKSRIHMNDNRWHQVSIRRPGPK 1076
            |...:|.::||.|..|||:|||||.|:|||.||||:||..::..|...:|||:||.|.|.|....
  Rat   913 TTSADGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSN 977

  Fly  1077 THTLTVDDSFEIISLTGNNMHLELAGILYIGGVFKDMYSKLPASISSRSGFEGCLASLDLGDASP 1141
            ||:|.||... :..:.....:|:|.|.||:.|:.:.|||.||..::||.||:|||||:||....|
  Rat   978 THSLKVDTKV-VTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLP 1041

  Fly  1142 SLTSDAVVPSSLVVSGCE---------GP-TKCSQNACANRGNCVQQWNAYACECDMTSYTGPTC 1196
            .|.:||:..|..:..|||         || |.|.:::|||:|.|:|||..:.|:|.||||:|..|
  Rat  1042 DLINDALHRSGQIDRGCEVALTKADLQGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQC 1106

  Fly  1197 YDESIAYEFGNNKGMVQYTFPENAQADTEEDNIALGFITTRPDAVLLRVESAT-TQDYMELEIVE 1260
            .|....|.||.:.|::.||:|.|.:..|..|.:|:||.||..|.:|:|::||. ..|:::|.|.:
  Rat  1107 NDPGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQ 1171

  Fly  1261 GNIFMVYNIGSVDLPLGEIGTKVNDNAYHVVRFQRKGGNATLQLDDYNV---------------- 1309
            |.|.:|:|||:||:.:.|..|.|||..||||||.|.|||||||:|::.|
  Rat  1172 GKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGNTDNERLQM 1236

  Fly  1310 --------------QALTPQSHHSTVFNTMSNVQVGGKFSRNGRNRIERPFAGVIAGLSVNKLRI 1360
                          :.|..:....|:|||.:.:.:|||    .:.|:   |.|.::||..:.|::
  Rat  1237 VKQKIPFKYNRPVEEWLQEKGRQLTIFNTQAQIAIGGK----DKGRL---FQGQLSGLYYDGLKV 1294

  Fly  1361 LDLAVERDPHITIRGDVQLV--------------------TGVLDRNDLQRMQQTLNSTRQTPAS 1405
            |::|.|.:|:|.|.|.|:||                    |.|::..  ..|..|.....::.||
  Rat  1295 LNMAAENNPNIKINGSVRLVGEVPSVSGTTQTTSMPPEMSTTVMETT--TTMATTTTRKNRSTAS 1357

  Fly  1406 GYPGALDDLIFSGAGSGCRGDDED--ECTPPFESG-SGDDLITPVYV------------------ 1449
            ..|.: |||:.|   :.|..||||  ||.|  .:| ||.:|:.|:.|
  Rat  1358 IQPTS-DDLVSS---AECSSDDEDFVECEP--STGRSGGELVIPLLVEDPLATPPIATRVPSITL 1416

  Fly  1450 PPTKQ---TTTSQQGNSLSTGGSSSGGVITNGTERACDDEDCV---HGSGDYGETTEQFTSTSTA 1508
            |||.:   |......:|||....:....:::.....|||:..|   :|||      |.|.|
  Rat  1417 PPTFRPLLTIIETTKDSLSMTSEAGLPCLSDQGSDGCDDDGLVISGYGSG------ETFDS---- 1471

  Fly  1509 RGSESNNEMVTITTTGRSDVTTEQHQGSSSSSSSGSTPSYATTQS-SSSSSSGGSAASTPGQVST 1572
                      .:..|...|..|              |.|..|.:| |:|...||..|..|
  Rat  1472 ----------NLPPTDDEDFYT--------------TFSLVTDKSLSTSIFEGGYKAHAP----- 1507

  Fly  1573 TSSVATSSTQRATSSSTSTSSSTTSTTTTTTTTQATPPPEIRSTVTERETTPYDIYIAGGGM--- 1634
                     :..:........|.||.||||:.:    |..||.|.:           :..||
  Rat  1508 ---------KWESKDFRPNKVSETSRTTTTSLS----PELIRFTAS-----------SSSGMVPK 1548

  Fly  1635 -GGSGRNDHDRMQLPDEHHPLPPLPPPIPPQDPPPYGPYGGNTYNTNMNNYRPKGKG-----GRI 1693
             .....|:.|....||  ..|.|||............|...:....|:....|...|     |..
  Rat  1549 LPAGKMNNRDLKPQPD--IVLLPLPTAYELDSTKLKSPLITSPMFRNVPTANPTEPGIRRVPGAS 1611

  Fly  1694 NSIEE--ERTAMIIGIVAGILIAVVLVILLVLWLKSNGDRG-YKTESEKAAAYGSHNPNAALLGN 1755
            ..|.|  ..|.|::||||...:. :|::|..::...|.|.| |:.:..:     ::..|:|
  Rat  1612 EVIRESSSTTGMVVGIVAAAALC-ILILLYAMYKYRNRDEGSYQVDETR-----NYISNSA---- 1666

  Fly  1756 TSTNGSYHQQRQHHMHGGGGGGGAGQQQHHAQQQ 1789
             .:||:..:::|           |..:..|.:|:
  Rat  1667 -QSNGTLMKEKQ-----------ASSKSGHKKQK 1688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058	46/159 (29%)
		EGF_CA	311..347	CDD:238011	14/35 (40%)
		Laminin_G_2	386..517	CDD:280389	54/132 (41%)
		LamG	555..716	CDD:238058	70/167 (42%)
		EGF	746..777	CDD:278437	16/30 (53%)
		Laminin_G_2	814..945	CDD:280389	48/140 (34%)
		LamG	988..1136	CDD:238058	69/147 (47%)
		EGF	1164..1195	CDD:278437	16/30 (53%)
		Laminin_G_2	1233..1356	CDD:280389	53/153 (35%)
Nrxn3	XP_038967552.1	LamG	27..181	CDD:238058	48/165 (29%)
		EGF	202..231	CDD:394967	15/58 (26%)
		LamG	286..425	CDD:214598	55/140 (39%)
		LamG	482..631	CDD:214598	62/148 (42%)
		EGF_CA	659..692	CDD:238011	17/32 (53%)
		LamG	720..854	CDD:214598	48/144 (33%)
		Laminin_G_2	911..1039	CDD:396680	61/128 (48%)
		LamG	1112..1291	CDD:238058	65/185 (35%)
		Syndecan	1622..>1657	CDD:395821	11/35 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I4871
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H83225
Inparanoid	1	1.050	831	1.000	Inparanoid score	I428
OMA	1	1.010	-	-		QHG46386
OrthoDB	1	1.010	-	-		D24127at33208
OrthoFinder	1	1.000	-	-		FOG0001168
OrthoInspector	1	1.000	-	-		otm46164
orthoMCL	1	0.900	-	-		OOG6_103392
Panther	1	1.100	-	-	O	PTHR15036
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X794
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980