DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-1 and LOC101883589

DIOPT Version :9

Sequence 1:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster
Sequence 2:	XP_005157778.2	Gene:	LOC101883589 / 101883589	-ID:	-	Length:	3016	Species:	Danio rerio

Alignment Length:	1778	Identity:	362/1778 - (20%)
Similarity:	598/1778 - (33%)	Gaps:	537/1778 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 RSEQVPPVVVEYRRSYRVLIVSALLVSLAASFVTLSAGFQLDGSQNSFYTFRKWYTG-LNGTLEL 130
            :.:.:||:..:...|:.|:..:    ..|..|:         .||..|:.......| :.|.::.
Zfish  1285 KDKGLPPIAAQTEISFEVIQEN----QFAPQFL---------NSQVEFFVPEDLPVGSVIGKIQG 1336

  Fly   131 EFKTEQPNGLVLYTDDGGTYD-FFELKLVEGALRLRYNLGGGAQIITVGRELHDGHWHKVQVLRN 194
            :.|....||::.|:.|||..: .|.::...|.:           ::..|.:......|.:.|:..
Zfish  1337 KDKDVGSNGVISYSFDGGNENGLFSIEHFSGLI-----------MLVKGLDFEKSETHHLSVIAK 1390

  Fly   195 DEQTSLIVDGVSQQRSTKGKEFQFGKFASNSDVYVGGM---PNWYSSKLALLALPSVIFEPRFRG 256
            |          ...|..||:        .|..|||..:   |..::||..:.:    :.|..|.|
Zfish  1391 D----------GGWRPKKGR--------LNVTVYVTDLNDNPPIFTSKDYVAS----VLENAFIG 1433

  Fly   257 AIRNLVYA-DQPGGSTRRQEIKQQ--RDIKCGDVPCDHGELPARERPLRGVRGGNTTDACERNDP 318
            .:...|:| |...|      |..|  ..:..||         |:...|....|..||......:.
Zfish  1434 TLVLQVWAKDSDTG------IHSQITYSVIAGD---------AQLFSLDSKNGSITTLEIFDYEQ 1483

  Fly   319 CQHGGICI-STDSGP--ICECRNLEYDGQYCE----KEKAP-----------SEATFRGTQFLS- 364
            .||..:.: :|:.||  :.:...:     |.:    .|..|           |||....|:..|
Zfish  1484 NQHFELTVKATNIGPPFLFDIARI-----YIQVVGVNEFIPAFQRHLYNFSVSEALMPQTEIGSI 1543

  Fly   365 ----YDLGQTGAEPIVSAQDAISFYFRTRQPNGLLF----YTG------------HGTDYLNLAL 409
                ||||..|.          .||....|.....|    :||            ...|.|::..
Zfish  1544 LATDYDLGPDGE----------VFYILVGQSKKSNFVVDKHTGKIYIAKDLKTRLKNEDVLHVLA 1598

  Fly   410 RDGGVSLTMGLANGKQEMHIK------PSKVRFDDHQWHKVTVHRRIQEISSITSFCRLVTVVDD 468
            ::.| ::| |....:..:|:.      |.:.   |...:.|.|.   ::||..||..::..|..|
Zfish  1599 KNRG-AIT-GFNVDEALIHLSILDENDPPEF---DSMLYIVAVS---EDISIGTSIAKVKAVDPD 1655

  Fly   469 V--------YT-DHSHIAGKFTMLSSSRVYVGGAVNPRALLGARVHTNFVGCLRKVEFSADTLN- 523
            |        |: :|.:|...|.:..     |.|.::..:.|...:...:...:..|:..:.::.
Zfish  1656 VILEWSRFSYSIEHGNINSSFIIDP-----VSGVISVNSHLDREIWAIYNLTVIAVDEGSPSVTG 1715

  Fly   524 -----LNLIDLAKSGSKLIQVAGNLEYQCPSGDPQDPVTFTTRESHLVLPP-------WETGKQS 576
                 :.:.|:..|..||:...|.:.    ...|.|.:..|...:...|||       |......
Zfish  1716 STKVAITVNDINDSPPKLLTTEGFIR----ENQPADTLVSTLTATDDDLPPNQGPFTYWMMRPAE 1776

  Fly   577 SISFKFRTKEPNGIIVLATGSKQPRAKNPVLIAIELLNGHIYIHLDLGSGASKVRASRRRVDDGD 641
            ..|.   |.|.    ||.|.....|..:|      |.:.||.:     ..|.|...|...:
Zfish  1777 GFSL---TTEG----VLVTSKPFDREHDP------LFHMHIVV-----QDAGKPPMSSTTL---- 1819

  Fly   642 WHDLILRRNG-----RDAKVSVDGVWNDFRTPGDGTILELDGHMYLGGVGPA-YNSVSWPAAIWT 700
            :|..:|..|.     |:..:.|....:.|  ||.          .:|.|.|. .:.:.    ::.
Zfish  1820 FHIKVLDENDNAPVPRNINILVKYYGSSF--PGG----------LIGNVRPTDLDELD----VFN 1868

  Fly   701 ATLRQG--------FVGC-LRDLVLSGKA-IDIAAFARVQDSASVKPSCHVQANVCNGNPCLNGG 755
            .|:|.|        |..| |......|:| .:|:..|..|...||..|.:|.
Zfish  1869 CTIRNGQPRMFSFPFGMCNLWSSPYQGEATYNISVEASDQLHPSVNNSIYVN------------- 1920

  Fly   756 TCLEGWNRPICDCSATLYGGPTCGRELATLAFNGSQHMTIWLGNGQGTKTQTEELVIRFKTSRPA 820
              .:|:.....|.....|...:...|..:|.:.........|.|.|.:||....:.::...
Zfish  1921 --YKGFTNVSLDNCVLFYVSISTLEEFLSLKYLKFVKALDSLFNLQASKTHVFGMKLQGDK---- 1979

  Fly   821 GLLLLTSAESNSPDRLEIALVAGRVRASVRLSDREKNLLAGQSVLNDNNWHTIRFSRRASN---L 882
             :|||.:.:|.:...|...:.:|       :|...|.||..||        .:..|:..||   |
Zfish  1980 -MLLLAAVKSYNGQYLTGEVASG-------ISSMHKKLLEAQS--------NVTISQITSNPCML 2028

  Fly   883 RLQVDGAPPVRGMLSETILGRHSTMEIRSVHLGGLFHAEE---EIQMTSTMPNFVGQMQGLVF-- 942
            |...:||...|.:        |.:.|:..:....|.....   ||...:....|.|....|.|
Zfish  2029 RPCHNGATCNRNI--------HISQEVAVLESSSLIFVSPYFMEIFNCTCPTGFTGDACELDFDE 2085

  Fly   943 -------NGQR-------------------YLDIVKSLGPELSALPSATF--------------- 966
                   ||..                   :..||.:....:..|...|.
Zfish  2086 CAKEPCENGGNCYNNPGTYFCQCKEGFSGPHCTIVDNECQTVVCLNGGTCWNRQGGFICDCSPGY 2150

  Fly   967 ------KLTARFVNSPA--GQ------------PYHAATFRSKHSYVGLAMLK---------AYN 1002
                  ::....|:||.  |.            |:..:.........|...|.         .||
Zfish  2151 EGRFCDRIVDHCVSSPCVYGNCSSLFTGYSCQCPFGVSGVNCDEQSYGFQELSYIEYPPLDPQYN 2215

  Fly  1003 SISIDFRFKTVEPNGLLVFNGGR--RNDFVAVELVNGHIHYTFDLGDGPVTMRDKSRIHMNDNRW 1065
            .|.::  |.||:.|.||::|.|:  .:||:|:|:::|.:..::|||.|.:.: :..:| :.|..:
Zfish  2216 FIYLE--FATVQQNALLLYNHGKPSTSDFLALEILSGRLFLSYDLGSGVIRL-ETGKI-IADGLF 2276

  Fly  1066 HQVSIRRPGPKTHTLTVDDS--FE-------IISLTGNNMHLEL-AGILYIGGVFKDMYSKLPAS 1120
            |.:|:||.| ...:|.:|:.  :|       ....|||...||: :..:..||| |.:.:.|...
Zfish  2277 HNISVRRSG-NMASLEIDNCSVYEPQGFCTTQTGATGNQRTLEVSSNNMTFGGV-KSIDAILLRQ 2339

  Fly  1121 ISSRSGFEGCLASLDLGDASP----SLTSDAVVPSSLVVSGCEGP--TKCSQNACANRGNCVQQW 1179
            |.:.. |.||:.:|.:.:..|    ||.|..::|.      |...  ..|....|.|.|.|..||
Zfish  2340 IRTHD-FVGCMRNLQVNNIRPDSLKSLASHNILPR------CPRTDIPPCEAAVCLNEGVCQDQW 2397

  Fly  1180 NAYACECDMTSYTGPTCYDESIAYE---FGNNKGMVQYTFPEN--------AQADTEEDNIALGF 1233
            :.:.|:| ...:|||:| ..::|.:   |.|.:..|::...|:        |..|:.::..:|||
Zfish  2398 SHHRCQC-RDHFTGPSC-AMNLAEQHVLFLNGEAYVKFDVKESYRRNQLLQAILDSGKEGDSLGF 2460

  Fly  1234 -------ITTRPDAVLLRVESATTQDYMELEIVEGN-IFMVYNIGS-VDLPLGEIGTKVNDNAYH 1289
                   .|.|.:.||:...|.:.  |::|:|.:|. ::|..|:.| ..|.|...| .|:|..:|
Zfish  2461 DSVEIKMRTVRRNGVLVVCWSQSA--YLKLKISDGKPLYMFTNVTSGHQLELSVEG-NVSDGQWH 2522

  Fly  1290 VVRFQRKGGNATLQLDDYNVQALTPQS-HHS-----TVFNTMSNVQVGGKFSRNGRNRIERPFAG 1348
            |:..:|:|...:|.|||..|...|..: .||     |:|...|.|            |..|.|..
Zfish  2523 VLHLRRRGSLFSLFLDDRPVANTTNGTIAHSAFLVETIFLGSSPV------------RESREFPE 2575

  Fly  1349 VIAGLSVNKLRILDLAVERDPHITIRGDVQLVTGVLDRNDLQRMQQTLNSTRQ----------TP 1403
            :|..|....      .||   :|...|.:....|   .||:...:.:|::.:.          ||
Zfish  2576 IIQNLGFRG------CVE---YIKYNGHLLSFNG---HNDIVESRSSLSAFQTFCVSPSHCVLTP 2628

  Fly  1404 ASGYPGALDDLIFS-------GAGSGCRGD----------------------DEDECTPPFES-- 1437
                  .|:|...|       ..||..|.|                      ..|.|:|..::
Zfish  2629 ------CLEDSCLSEPCWNNTDCGSSSRDDYWCICLPNTPESSCGSCSSELIHSDPCSPSKKTAP 2687

  Fly  1438 -----------------------------GSGDDLITPVYVPPTK----------------QTTT 1457
                                         |.|:.......:||::                |.|:
Zfish  2688 LWIVAVVVPIALILLILVLCFVLRRHQNHGEGEKKSHNYLMPPSRPHGMDNLAFSLSPTEIQNTS 2752

  Fly  1458 SQ---QGNSLSTGGSSSGGVITNGTERACDDEDCVHGSGDYGETTEQFTSTSTARGSESNNEMVT 1519
            ::   |.:.:.|..|      |.|.|...:.....|.||..|...|.:...||     .:|.|.|
Zfish  2753 NEPNKQPDLIKTRDS------TQGVESFTESGPLCHVSGFAGSELEYYEIDST-----YSNVMKT 2806

  Fly  1520 ITTTGRSDV--TTEQHQGSSSSS 1540
            ......:.|  :|.|.|.:...|
Zfish  2807 EDEQANAKVPQSTMQPQNNHKPS 2829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058	31/157 (20%)
		EGF_CA	311..347	CDD:238011	6/38 (16%)
		Laminin_G_2	386..517	CDD:280389	29/161 (18%)
		LamG	555..716	CDD:238058	36/182 (20%)
		EGF	746..777	CDD:278437	3/30 (10%)
		Laminin_G_2	814..945	CDD:280389	30/145 (21%)
		LamG	988..1136	CDD:238058	47/168 (28%)
		EGF	1164..1195	CDD:278437	11/30 (37%)
		Laminin_G_2	1233..1356	CDD:280389	39/137 (28%)
LOC101883589	XP_005157778.2	Cadherin_repeat	76..169	CDD:206637
		Cadherin_repeat	178..276	CDD:206637
		Cadherin_repeat	285..379	CDD:206637
		Cadherin_repeat	387..479	CDD:206637
		Cadherin_repeat	498..585	CDD:206637
		Cadherin_repeat	593..689	CDD:206637
		Cadherin	698..783	CDD:278457
		Cadherin_repeat	798..892	CDD:206637
		Cadherin_repeat	900..996	CDD:206637
		Cadherin_repeat	1003..1097	CDD:206637
		Cadherin_repeat	1105..1194	CDD:206637
		Cadherin_repeat	1213..1306	CDD:206637	4/20 (20%)
		Cadherin_repeat	1318..1413	CDD:206637	23/123 (19%)
		Cadherin_repeat	1422..1516	CDD:206637	22/117 (19%)
		Cadherin_repeat	1526..1623	CDD:206637	22/108 (20%)
		Cadherin_repeat	1632..1728	CDD:206637	18/103 (17%)
		Cadherin_repeat	1737..1830	CDD:206637	25/118 (21%)
		EGF_CA	2082..2118	CDD:238011	3/35 (9%)
		EGF_CA	2122..2155	CDD:238011	2/32 (6%)
		LamG	2196..2355	CDD:238058	47/165 (28%)
		EGF_CA	2378..2413	CDD:238011	12/35 (34%)
		Laminin_G_2	2467..2594	CDD:280389	41/150 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910