DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrx-1 and slc7a14

DIOPT Version :9

Sequence 1:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster
Sequence 2:	XP_002931595.1	Gene:	slc7a14 / 100493085	XenbaseID:	XB-GENE-1010371	Length:	768	Species:	Xenopus tropicalis

Alignment Length:	299	Identity:	60/299 - (20%)
Similarity:	104/299 - (34%)	Gaps:	98/299 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   468 DVYTDHSHIAGKFTMLSSS----RVYVGGAVNPR-----------------ALLGARVHTNFVGC 511
            :::..|...|.||.:...|    .|.:.|::.|.                 |.:.:...|..|.|
Frog   323 EMFVVHGFYAAKFVVAVGSVAGLTVSLFGSLFPMPRVIYAMAGDGLLFKFLAHVSSYTETPVVAC 387

  Fly   512 LRKVEFSADTLNL-----NLIDLAKSGSKLIQVAGN-----LEYQCPSGDPQDPVTFTTRESHLV 566
            :.. .|.|..|:|     :||::...|:.|.....:     |.|| |..|....|.|.:.|:
Frog   388 VVS-GFLAGLLSLLVSLRDLIEMMSIGTLLAYTLVSVCVLLLRYQ-PESDIDGFVKFISEEN--- 447

  Fly   567 LPPWETGKQSSISFKFRTKEPNGIIVLATGSKQPRAKNPVLIAIELLNGHIYIHLDLGSGASKVR 631
                             ||:..||  ||...|.  |.:|      :.:|.     :....|:...
Frog   448 -----------------TKKKEGI--LADCEKD--ACSP------MSDGE-----EFSGPATNTC 480

  Fly   632 ASRRRVDDGDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTI-----LELDG--HMYL----GGV 685
            .::.....|| :::::.::        |....:...|..||:     :|.||  :.||    ..:
Frog   481 GAKNLPSLGD-NEMLIGKS--------DKSHYNINHPNYGTVDMTSGIEADGSENRYLFKIKKFI 536

  Fly   686 GPAYNSVSWPAAIWTATLRQGFVGCL-RDLVLSGKAIDI 723
            ||.|         :|..:|.|..|.: |....:|:.:.|
Frog   537 GPRY---------YTLRIRLGLPGKMDRPTAATGRTVTI 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058
		EGF_CA	311..347	CDD:238011
		Laminin_G_2	386..517	CDD:280389	12/69 (17%)
		LamG	555..716	CDD:238058	33/172 (19%)
		EGF	746..777	CDD:278437
		Laminin_G_2	814..945	CDD:280389
		LamG	988..1136	CDD:238058
		EGF	1164..1195	CDD:278437
		Laminin_G_2	1233..1356	CDD:280389
slc7a14	XP_002931595.1	2A0303	20..676	CDD:273330	60/299 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7419
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.890