Protein Alignment Nrx-1 and agrn

DIOPT Version :10

• Sequence 1: NP_001262840.1
• Gene: Nrx-1 / 42646
• FlyBaseID: FBgn0038975
• Length: 1847
• Species: Drosophila melanogaster
• Sequence 2: XP_017951501.1
• Gene: agrn / 100492176
• XenbaseID: XB-GENE-953967
• Length: 2109
• Species: Xenopus tropicalis
• Alignment Length: 749
• Identity: 183/749 - (24%)
• Similarity: 293/749 - (39%)
• Gaps: 190/749 - (25%)

  Fly   113 SFYTFRKWYTGLNGTLELEFKTEQPNGLVLYTDDGGTYDFFELKLVEGALRLRYNLGGGAQIITV 177
            :::|.|         :.:||::.:.|||:||.......||..|.:..|.:.||:|.|.|..|||.
 Frog  1432 AYHTVR---------IAMEFRSSEQNGLLLYNGQSLGKDFISLAVNNGFVELRFNTGSGTGIITS 1487

  Fly   178 GRELHDGHWHKVQVLRNDEQTSLIVDGVS-----QQRSTKGKEFQFGKFASNSDVYVGGMPNWYS 237
            ...:..|.||::.|.||.....|.|||.|     ....|.|...       ::|:::||.|   .
 Frog  1488 KVPIEPGKWHQLVVNRNRRSGMLSVDGESHVNGESPSGTDGLNL-------DTDLFIGGAP---E 1542

  Fly   238 SKLALLALPSVIFEPRFRGAIR-----NLVYADQPGGSTRRQEIKQQRDI-------KCGDVPCD 290
            .::|::: .........:|.||     |.:|..|.||:          |:       :||:.||.
 Frog  1543 DQMAVVS-ERTSLSVGLKGCIRQLDVNNQLYNLQEGGA----------DVLYGSGVGECGNNPCQ 1596

  Fly   291 ----HGELPARERP--------LRGVRGGNTTDACERN----DPCQHGGIC-ISTDSGPICECRN 338
                |.....:.:.        |.|..|....|  |||    :||.....| :..:.|..||| .
 Frog  1597 PNPCHNGAACQVKEAEMFHCQCLSGYTGPTCAD--ERNPCDPNPCHVSATCLVLPEGGAKCEC-P 1658

  Fly   339 LEYDGQYCEKE-----KAPSEATFRGTQFLSYDLGQTGAEPIVSAQD--AISFYFRTRQPNGLLF 396
            :..:|::|||.     ..|....|.|..:|.....||.|..:   ||  |:...|....||||:|
 Frog  1659 MGREGEFCEKVSNQDLNLPFLPQFNGYSYLEMKGLQTFATDL---QDKLAMEVVFLASNPNGLIF 1720

  Fly   397 YTGHGT----DYLNLALRDGGVSLTMGLANGKQEMHIKPSKVRFDDHQWHKVTVHR-------RI 450
            |.|..|    |:::|:|.||.:.....|  ||....|| ||.:...:.|..|::.|       ||
 Frog  1721 YNGQKTDGKGDFVSLSLHDGNLEYRYDL--GKGAAVIK-SKEKIPLNTWLSVSLERSGRKGLMRI 1782

  Fly   451 QEISSITSFCRLVTVVDDVYTDHSHIAGKFTMLSSSRVYVGGAVN-PRALLGARVHTNFVGCLRK 514
            ..:..:|.           .:..|..|....:.....::||||.: .:....|...|:|.|.::|
 Frog  1783 NNMEQVTG-----------ESPKSRKAPHTALNLKEPLFVGGAPDFSKLARAAAASTSFEGAIQK 1836

  Fly   515 VEFSADTL----NL-NLIDLA--------------KSGSKLIQVAGNLEYQCP---SGDPQDPVT 557
            :......:    |: :.|:::              ::|.......||.|..|.   ||...:.||
 Frog  1837 ISIKGLPVLREENIRSAIEISTFRSHPCTKKPFPCQNGGLCSPNKGNYECVCQRGFSGSQCEKVT 1901

  Fly   558 F---------------TTRESHLV---------LPPWETG---------------KQSSISFKFR 583
            .               |..|.|:.         :|  |||               .|..:|.|
 Frog  1902 IEKAAGESEAVSFDGKTYLEYHIAVTKSQLTNEIP--ETGPVDNPDDPSEKALLVNQFELSIK-- 1962

  Fly   584 TKEPNGIIVLATGSKQPRAKNPVLIAIELLNGHIYIHLDLGSGASKVRASRRRVDDGDWHDLILR 648
            |:...|:| |.:|....||   ..||:.::.|::.:..||||....:| |...|:..:|..:...
 Frog  1963 TEATQGLI-LWSGKGTERA---YYIALAVVGGYVEMTYDLGSKPVVLR-STVPVNTNEWIHIKAV 2022

  Fly   649 RNGRDAKVSVDGVWNDFRTPGDGTI----LELDGHMYLGGVGPAYNSVSWPAAIWTATLRQGFVG 709
            |:.||..:.|.   |:....|....    |:.||.::|||:.....|...|.|..|     ||:|
 Frog  2023 RDNRDGILRVG---NEDPVHGSSPFGVKELDTDGALWLGGIEKLSASYKLPKAYST-----GFIG 2079

  Fly   710 CLRDLVLSGKAIDIAAFARVQDSASVKPSCHVQA 743
            |::|:::..:.:.:     |:|:.:..|..:..|
 Frog  2080 CMKDVLVDQQDLHL-----VEDALNKPPILYCSA 2108

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058	43/159 (27%)
		EGF_CA	311..347	CDD:238011	12/40 (30%)
		Laminin_G_2	386..517	CDD:460494	38/142 (27%)
		LamG	555..716	CDD:238058	51/203 (25%)
		EGF	746..777	CDD:394967
		Laminin_G_2	814..945	CDD:460494
		Laminin_G_2	1010..1138	CDD:460494
		Laminin_G_2	1233..1356	CDD:460494
agrn	XP_017951501.1	NtA	30..145	CDD:460825
		KAZAL	204..247	CDD:197624
		KAZAL	276..322	CDD:197624
		KAZAL	351..394	CDD:197624
		KAZAL	421..466	CDD:197624
		KAZAL	495..540	CDD:197624
		KAZAL	560..605	CDD:197624
		KAZAL	634..670	CDD:197624
		KAZAL	711..757	CDD:197624
		Laminin_EGF	798..840	CDD:395007
		Laminin_EGF	852..>888	CDD:395007
		KAZAL	<941..974	CDD:197624
		SEA	1147..1268	CDD:214554
		EGF	1377..1405	CDD:394967
		LamG	1419..1568	CDD:238058	42/155 (27%)
		EGF	1595..1626	CDD:394967	5/30 (17%)
		Laminin_G_1	1710..1845	CDD:395008	38/148 (26%)
		EGF_CA	<1870..1898	CDD:238011	7/27 (26%)
		Laminin_G_1	1961..2092	CDD:395008	40/145 (28%)