Protein Alignment AP-2mu and APM2

DIOPT Version :10

• Sequence 1: NP_651049.3
• Gene: AP-2mu / 42642
• FlyBaseID: FBgn0263351
• Length: 437
• Species: Drosophila melanogaster
• Sequence 2: NP_011844.1
• Gene: APM2 / 856367
• SGDID: S000001011
• Length: 605
• Species: Saccharomyces cerevisiae
• Alignment Length: 627
• Identity: 141/627 - (22%)
• Similarity: 223/627 - (35%)
• Gaps: 235/627 - (37%)

  Fly     1 MIGGLFVYNHKGEVLISRVYRDDIGRNAV-DAFRVNVIHARQQVRSPVTNIARTSFFHIKRANIW 64
            |...||:.:...|.|:|:..|.....::| .:|:    ........|:.:.....|.|:||..:.
Yeast     1 MSSSLFILDENLEPLVSKNIRALPNLSSVLSSFK----QCYHDGSPPILSQNDWFFIHLKRDFLH 61

  Fly    65 LAAV----TKQNVNAAMVFEFLLKIIEVMQSYF--GKISEENIKNNFVLIYELLDEILDFGYPQN 123
            ..:|    .|.|::...:..||.:...::|.||  ..:::..|.:|.:|:.||:||.:|||..|.
Yeast    62 FVSVIHTTDKPNIDLMTILAFLEQFYHLLQKYFEIEVLTKNVILDNILLVLELIDECIDFGIVQV 126

  Fly   124 TDSGTLKTFI------------------------------------------------------- 133
            ||...:|.:|
Yeast   127 TDPSIIKDYIRVKVNVPRVTVDNEEWSPGEESSSSSGSDSDSEYSNTNKRKDKKKKRKKKKGTKG 191

  Fly   134 ----------------TQQGI-----------------KSATKEE----------QMQITSQVTG 155
                            ..:||                 |.|..:|          ...|...:..
Yeast   192 KSVGKSKLKSIMVNNKENRGINVVETVKETLRNKNDTGKEAANDELPNDGNDLYINGDIAKTIIM 256

  Fly   156 QIGWRREGIKYRRNELFLDVLEYVNLLMS-PQGQVLSAHVAGKVVMKSYLSGMPECKFGINDKIV 219
            .|.||.:||.|.:||.||||:|.|..||. .:|.:....:.|::|.:.||||||:.|..||.  :
Yeast   257 PISWRTKGIHYAKNEFFLDVIERVQYLMDFEKGVIRKNLIHGEIVCRCYLSGMPKLKISINK--I 319

  Fly   220 MESKGRGLSGNSEAETSRSGKPVVVIDDCQFHQCVKLSKFET--------------------EHS 264
            :....:.:|.:|                  |||||.|....|                    ...
Yeast   320 LNRDPQFMSNSS------------------FHQCVSLDSINTIEKDEEKNSDDDAGLQAATDARE 366

  Fly   265 ISFIPPDGEFELMRY---RTTKDISLPFRVIPLVR--------EVGRTKMEVKVVLKSNFKPSLL 318
            |.||||||||.|.:|   |..||       .|:||        ::.:.|:::...:::||||:..
Yeast   367 IEFIPPDGEFVLCQYELKRHVKD-------APMVRLKDFEIKPKLKKFKIQIVTKIQTNFKPTNS 424

  Fly   319 GQKIEVKIPTPLNTSGVQLICLK--------GKAKYKASENAIVWKIKRMAGMKE--TQLSA--- 370
            ..|:.|:||........::...|        ||..:..|::.::|:|:.|.|.:|  |..|:
Yeast   425 TSKLNVRIPLTKVFQEYKIDLSKQIRFKANIGKVVFNLSDDFLLWEIQTMKGHREHSTNKSSQYN 489

  Fly   371 ----------------------EIELLETDTKKKWTRPP-------------------------- 387
                                  |.:.|:.:.|.....||
Yeast   490 SDEDDPNTCASMVAEFPLFNQEEYDRLQEEMKTSMNPPPLRTGPRLEELYRQVHDQQTSHVTPRD 554

  Fly   388 --ISMNFEVPFAP-SGFKVRYLKVFEPKLNYSDHDVVKWVRY 426
              ::::||:|:.. ||.||.||||.||:|.|..   ..||||
Yeast   555 KLVNIDFEIPYCTCSGLKVEYLKVEEPQLQYQS---FPWVRY 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-2mu	NP_651049.3	AP2_Mu_N	1..140	CDD:341440	39/233 (17%)
		AP-2_Mu2_Cterm	166..436	CDD:271159	93/357 (26%)
APM2	NP_011844.1	AP_Mu_N	3..138	CDD:341432	36/138 (26%)
		AP-1_Mu1_Cterm	256..603	CDD:271158	98/368 (27%)