Protein Alignment AP-2mu and APM1

DIOPT Version :10

• Sequence 1: NP_651049.3
• Gene: AP-2mu / 42642
• FlyBaseID: FBgn0263351
• Length: 437
• Species: Drosophila melanogaster
• Sequence 2: NP_015064.1
• Gene: APM1 / 855869
• SGDID: S000006180
• Length: 475
• Species: Saccharomyces cerevisiae
• Alignment Length: 478
• Identity: 169/478 - (35%)
• Similarity: 259/478 - (54%)
• Gaps: 58/478 - (12%)

  Fly     1 MIGGLFVYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQ--VRSPVTNIARTSFFHIKRANI 63
            |...::..:|.|:.|:||.|||||..:|:|.|.:.:....:|  :..|..|.....:..|:..::
Yeast     1 MASAVYFCDHNGKPLLSRRYRDDIPLSAIDKFPILLSDLEEQSNLIPPCLNHNGLEYLFIQHNDL 65

  Fly    64 WLAA-VTKQNVNAAMVFEFLLKIIEVMQSYFGKISEENIKNNFVLIYELLDEILDFGYPQNTDSG 127
            ::.| ||..:.|||.:|.||.|::||:..|...:.||:|::|||:|||||||::|:|.||.|::.
Yeast    66 YVVAIVTSLSANAAAIFTFLHKLVEVLSDYLKTVEEESIRDNFVIIYELLDEVMDYGIPQITETK 130

  Fly   128 TLKTFITQQG---IKSATKEEQ-MQITSQVTGQIGWRREGIKYRRNELFLDVLEYVNLLMSPQGQ 188
            .||.:|||:.   :|||.|:.. .:....:|..:.||.|||.:::||.|||::|.:|:||:.:||
Yeast   131 MLKQYITQKSFKLVKSAKKKRNATRPPVALTNSVSWRPEGITHKKNEAFLDIVESINMLMTQKGQ 195

  Fly   189 VLSAHVAGKVVMKSYLSGMPECKFGINDKIVMES---------KGRGLSGNSEAETSRSGKPVVV 244
            ||.:.:.|.|.:.|.|||||:.|.|||||.:...         .....:.::..||.:  ||.:.
Yeast   196 VLRSEIIGDVKVNSKLSGMPDLKLGINDKGIFSKYLDDDTNIPSASATTSDNNTETDK--KPSIT 258

  Fly   245 -------------IDDCQFHQCVKLSKFETEHSISFIPPDGEFELMRYRTTKDISLPFRVIPL-- 294
                         ::|.:|||||:|||||.|..|:||||||:|:||.||.:..|.      ||
Yeast   259 SSSATNKKKVNIELEDLKFHQCVRLSKFENEKIITFIPPDGKFDLMNYRLSTTIK------PLIW 317

  Fly   295 ----VREVGRTKMEVKVVLKSNFKPSLLGQKIEVKIPTPLNTSGVQLICLKGKAKYKASENAIVW 355
                |:....:::|:....|:..|.......:|:.||.|.:..........|..||...::||:|
Yeast   318 CDVNVQVHSNSRIEIHCKAKAQIKRKSTATNVEILIPVPDDADTPTFKYSHGSLKYVPEKSAILW 382

  Fly   356 KIKRMAGMKETQLSAEIELLETDTKKKWTRP-----------PISMNFEVP-FAPSGFKVRYLKV 408
            ||:...|.||..:|||:.|......:...|.           |:.:.|::| |..||.:|||||:
Yeast   383 KIRSFPGGKEYSMSAELGLPSISNNEDGNRTMPKSNAEILKGPVQIKFQIPYFTTSGIQVRYLKI 447

  Fly   409 FEPKLNYSDHDVVKWVRYIGRSG 431
            .||||.|..:   .|||||.:||
Yeast   448 NEPKLQYKSY---PWVRYITQSG 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-2mu	NP_651049.3	AP2_Mu_N	1..140	CDD:341440	54/144 (38%)
		AP-2_Mu2_Cterm	166..436	CDD:271159	105/306 (34%)
APM1	NP_015064.1	AP1_Mu_N	3..143	CDD:341439	53/139 (38%)
		AP-1_Mu1_Cterm	161..471	CDD:271158	111/318 (35%)