DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-2mu and ap2m1

DIOPT Version :9

Sequence 1:	NP_001163686.1	Gene:	AP-2mu / 42642	FlyBaseID:	FBgn0263351	Length:	437	Species:	Drosophila melanogaster
Sequence 2:	NP_988975.1	Gene:	ap2m1 / 394572	XenbaseID:	XB-GENE-6258427	Length:	435	Species:	Xenopus tropicalis

Alignment Length:	439	Identity:	379/439 - (86%)
Similarity:	411/439 - (93%)	Gaps:	6/439 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIGGLFVYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHIKRANIWL 65
            ||||||:||||||||||||||||||||||||||||||||||||||||||||||||||:||:||||
Frog     1 MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVKRSNIWL 65

  Fly    66 AAVTKQNVNAAMVFEFLLKIIEVMQSYFGKISEENIKNNFVLIYELLDEILDFGYPQNTDSGTLK 130
            |||||||||||||||||.|:.:||.:||||||||||||||||||||||||||||||||:::|.||
Frog    66 AAVTKQNVNAAMVFEFLYKMCDVMTAYFGKISEENIKNNFVLIYELLDEILDFGYPQNSETGALK 130

  Fly   131 TFITQQGIKS--ATKEEQMQITSQVTGQIGWRREGIKYRRNELFLDVLEYVNLLMSPQGQVLSAH 193
            ||||||||||  .|||||.||||||||||||||||||||||||||||||.|||||||||||||||
Frog   131 TFITQQGIKSQHQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLESVNLLMSPQGQVLSAH 195

  Fly   194 VAGKVVMKSYLSGMPECKFGINDKIVMESKGRGLSGNSEAETSRSGKPVVVIDDCQFHQCVKLSK 258
            |:|:||||||||||||||||:|||||:|.:|:|.:.    ||.::||..:.||||.|||||:|||
Frog   196 VSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTAD----ETGKTGKQSIAIDDCTFHQCVRLSK 256

  Fly   259 FETEHSISFIPPDGEFELMRYRTTKDISLPFRVIPLVREVGRTKMEVKVVLKSNFKPSLLGQKIE 323
            |::|.||||||||||||||||||||||.||||||||||||||||:|||||:|||||||||.||||
Frog   257 FDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTKLEVKVVIKSNFKPSLLAQKIE 321

  Fly   324 VKIPTPLNTSGVQLICLKGKAKYKASENAIVWKIKRMAGMKETQLSAEIELLETDTKKKWTRPPI 388
            |:|||||||||||:||:|||||||||||||||||||||||||:|:|||||||.|:.||||.||||
Frog   322 VRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMKESQISAEIELLPTNDKKKWARPPI 386

  Fly   389 SMNFEVPFAPSGFKVRYLKVFEPKLNYSDHDVVKWVRYIGRSGLYETRC 437
            ||||||||||||.|||||||||||||||||||:||||||||||:|||||
Frog   387 SMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIKWVRYIGRSGIYETRC 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-2mu	NP_001163686.1	AP2_Mu_N	1..140	CDD:341440	125/138 (91%)
AP-2mu	NP_001163686.1	AP-2_Mu2_Cterm	166..436	CDD:271159	226/269 (84%)
ap2m1	NP_988975.1	AP2_Mu_N	1..140	CDD:341440	125/138 (91%)
ap2m1	NP_988975.1	AP-2_Mu2_Cterm	168..434	CDD:271159	226/269 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	489	1.000	Domainoid score	I380
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3000
Inparanoid	1	1.050	766	1.000	Inparanoid score	I540
OMA	1	1.010	-	-		QHG53686
OrthoDB	1	1.010	-	-		D274992at33208
OrthoFinder	1	1.000	-	-		FOG0003937
OrthoInspector	1	1.000	-	-		oto105518
Panther	1	1.100	-	-	LDO	PTHR10529
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R62
SonicParanoid	1	1.000	-	-		X2710
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110