DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-2mu and Ap1m2

DIOPT Version :9

Sequence 1:	NP_001163686.1	Gene:	AP-2mu / 42642	FlyBaseID:	FBgn0263351	Length:	437	Species:	Drosophila melanogaster
Sequence 2:	XP_038937777.1	Gene:	Ap1m2 / 367038	RGDID:	1561490	Length:	425	Species:	Rattus norvegicus

Alignment Length:	434	Identity:	168/434 - (38%)
Similarity:	265/434 - (61%)	Gaps:	18/434 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LFVYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQ-VRSPVTNIARTSFFHIKRANIWLAAV 68
            :|:.:.||:.||||.|:.|:....:|.|...::...:: :.:|:.:..|..|..||.:|::|.|.
  Rat     6 VFILDVKGKPLISRNYKGDVPMTEIDHFMPLLMQREEEGMLAPLLSHGRVHFLWIKHSNLYLVAT 70

  Fly    69 TKQNVNAAMVFEFLLKIIEVMQSYFGKISEENIKNNFVLIYELLDEILDFGYPQNTDSGTLKTFI 133
            |.:|.||::|:.||.|.:||...||.::.||:|::|||::||||||::|||:||.|||..|:.:|
  Rat    71 TLKNANASLVYSFLYKTVEVFCEYFKELEEESIRDNFVIVYELLDELMDFGFPQTTDSKILQEYI 135

  Fly   134 TQQGIKSATKEEQMQITSQVTGQIGWRREGIKYRRNELFLDVLEYVNLLMSPQGQVLSAHVAGKV 198
            ||||.|..|.:.::..|  ||..:.||.|||||::||:|:||:|.||||::..|.||.:.:.|.:
  Rat   136 TQQGNKLETGKSRVPPT--VTNAVSWRSEGIKYKKNEVFIDVIESVNLLVNANGSVLLSEIVGTI 198

  Fly   199 VMKSYLSGMPECKFGINDKIVMESKGRGLSGNSEAETSRSGKPVVVIDDCQFHQCVKLSKFETEH 263
            .:|.:||||||.:.|:||:::.|..|...|.|...|          ::|.:|||||:||:|:.:.
  Rat   199 KLKVFLSGMPELRLGLNDRVLFELTGLSGSKNKSVE----------LEDVKFHQCVRLSRFDNDR 253

  Fly   264 SISFIPPDGEFELMRYRTTKDISLPFRVIPLVREVGRTKMEVKVVLKSNFKPSLLGQKIEVKIPT 328
            :||||||||:||||.||.:..:.....:..::.:...:::|:.|..|..||...:...:|:.:|.
  Rat   254 TISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMVKAKGQFKKQSVANGVEISVPV 318

  Fly   329 PLNTSGVQLICLKGKAKYKASENAIVWKIKRMAGMKETQLSAEIELLETDTKKKWTRPPISMNFE 393
            |.:....:.....|.|||...:|.::|.||...|.||..:.|...|...:|::...||||.:.||
  Rat   319 PSDADSPRFKTSVGSAKYVPEKNVVIWSIKSFPGGKEYLMRAHFGLPSVETEEVEGRPPIGVKFE 383

  Fly   394 VP-FAPSGFKVRYLKVFEPKLNYSDHDVVKWVRYIGRSGLYETR 436
            :| |..||.:|||:|:.|.    |.:..:.|||||.:||.|:.|
  Rat   384 IPYFTVSGIQVRYMKIIEK----SGYQALPWVRYITQSGDYQLR 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-2mu	NP_001163686.1	AP2_Mu_N	1..140	CDD:341440	57/135 (42%)
AP-2mu	NP_001163686.1	AP-2_Mu2_Cterm	166..436	CDD:271159	99/270 (37%)
Ap1m2	XP_038937777.1	AP1_Mu_N	4..142	CDD:341439	57/135 (42%)
Ap1m2	XP_038937777.1	AP_MHD_Cterm	154..423	CDD:416027	106/282 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D725236at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920