DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-2mu and Ap4m1

DIOPT Version :9

Sequence 1:	NP_001163686.1	Gene:	AP-2mu / 42642	FlyBaseID:	FBgn0263351	Length:	437	Species:	Drosophila melanogaster
Sequence 2:	XP_006249070.1	Gene:	Ap4m1 / 304344	RGDID:	1310233	Length:	457	Species:	Rattus norvegicus

Alignment Length:	475	Identity:	132/475 - (27%)
Similarity:	217/475 - (45%)	Gaps:	58/475 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIGGLFVYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNI-ARTSFFHIKRANIW 64
            ||...|:.:.||:.||.:.:|.|.|...|.......:.......|||... ....|.||:.:.::
  Rat     1 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGGESPVVMYHDDRHFIHIRHSGLY 65

  Fly    65 LAAVTKQNVNAAMVFEFLLKIIEVMQSYFGKISEENIKNNFVLIYELLDEILDFGYPQNTDSGTL 129
            |.|.|.:||:...:.|.|.::..::..|.|.::|..|..|..|:||||||:||:||.|.|.:..|
  Rat    66 LVATTSENVSPFSLLELLSRLATLLGDYCGSLNEGTISRNVALVYELLDEVLDYGYVQTTSTDML 130

  Fly   130 KTFITQQ---------------GIKSATKEEQMQITSQVTGQIGWRREGIKYRRNELFLDVLEYV 179
            :.||..:               |:..|..::.....|....:........:.::||:||||:|.:
  Rat   131 RNFIQTEAAVSKPFSLFDLSSVGLFGAETQQNRVAPSSAASRPVLSSRSDQSQKNEVFLDVVERL 195

  Fly   180 NLLMSPQGQVLSAHVAGKVVMKSYLSGMPECKFGINDKIVMESKGRGLSGNSEAETSRSGKPVVV 244
            ::|::..|.:|...|.|::.:||:|....|...|:.::..:        |.||.   |...|.:.
  Rat   196 SVLIASNGSLLKVDVQGEIRLKSFLPSSSEICIGLTEEFCV--------GKSEL---RGYGPGIR 249

  Fly   245 IDDCQFHQCVKLSKFETEHSISFIPPDGE--FEL--MRYRTTKDI--SLPFRVIPLVR-EVGRTK 302
            :|:..||..|.|.:||:...:...||.||  |.|  |||:.:.|:  .||||:.|.|: :.|..:
  Rat   250 VDEVSFHSSVNLDEFESHRILHLQPPQGEVRFRLTVMRYQLSDDLPSPLPFRLFPSVQWDQGSGR 314

  Fly   303 MEVKVVLKSNFKPSLLGQKIEVKIPTPLNTSGVQLICLKGKAKYKASENAIVWKIKRMAGMKETQ 367
            ::|.:.|:.:..|......|.:.:|.|.....:.........|.:..|.|:.|.:.|:.|  .:|
  Rat   315 LQVYLKLRCDLPPKSQALNIHLHLPLPRGVVSLSQELSSPDQKAELGEGALHWDLPRVQG--GSQ 377

  Fly   368 LSAEIELLETDTKKKWTRP--------------PISMNFEVP-FAPSGFKVRYLKV-FEPKLNYS 416
            ||.   |.:.|.......|              |.|::||:| ...||.:||:|:: |....|.:
  Rat   378 LSG---LFQMDVPGLQGPPSRGPSPSAPPLGLGPASLSFELPRHTCSGLQVRFLRLSFSACGNAN 439

  Fly   417 DHDVVKWVRYIGRSGLYETR 436
            .|   ||||::..|..|..|
  Rat   440 PH---KWVRHLSHSNAYVIR 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-2mu	NP_001163686.1	AP2_Mu_N	1..140	CDD:341440	46/154 (30%)
AP-2mu	NP_001163686.1	AP-2_Mu2_Cterm	166..436	CDD:271159	83/292 (28%)
Ap4m1	XP_006249070.1	Clat_adaptor_s	1..130	CDD:261170	42/128 (33%)
Ap4m1	XP_006249070.1	AP-4_Mu4_Cterm	175..457	CDD:271161	84/301 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910