DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-2mu and apm4

DIOPT Version :9

Sequence 1:	NP_001163686.1	Gene:	AP-2mu / 42642	FlyBaseID:	FBgn0263351	Length:	437	Species:	Drosophila melanogaster
Sequence 2:	NP_592921.1	Gene:	apm4 / 2541527	PomBaseID:	SPAC31A2.09c	Length:	446	Species:	Schizosaccharomyces pombe

Alignment Length:	450	Identity:	176/450 - (39%)
Similarity:	283/450 - (62%)	Gaps:	19/450 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIGGLFVYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHIKRANIWL 65
            ||.|||::|.||:.||.:.:|.|:.::..:.|||.:: .....|.|:.:|..:::.:.|..::::
pombe     1 MISGLFIFNLKGDTLICKTFRHDLKKSVTEIFRVAIL-TNTDYRHPIVSIGSSTYIYTKHEDLYV 64

  Fly    66 AAVTKQNVNAAMVFEFLLKIIEVMQSYFGKISEENIKNNFVLIYELLDEILDFGYPQNTDSGTLK 130
            .|:||.|.|..:|.|||..:|:.:..||||::|..:|:|...|:|||||::|:|..|.|:...|.
pombe    65 VAITKGNPNVMIVLEFLESLIQDLTHYFGKLNENTVKDNVSFIFELLDEMIDYGIIQTTEPDALA 129

  Fly   131 TFITQQGIK------SATKEEQMQI----TSQVTGQIGWRREGIKYRRNELFLDVLEYVNLLMSP 185
            ..::...:|      |..:....|:    :|::.|.:.|||.|||||:|.:::|::|.:|||:|.
pombe   130 RSVSITAVKKKGNALSLKRSHSSQLAHTTSSEIPGSVPWRRAGIKYRKNSIYIDIVERMNLLISS 194

  Fly   186 QGQVLSAHVAGKVVMKSYLSGMPECKFGINDKI---VMESKGRGLSGNSEAETSRSGKPVVVIDD 247
            .|.||.:.|:|.|.|::.|||||||:||:|||:   :.:|:.:..|.||...:|.:| ..|:::|
pombe   195 TGNVLRSDVSGVVKMRAMLSGMPECQFGLNDKLDFKLKQSESKSKSNNSRNPSSVNG-GFVILED 258

  Fly   248 CQFHQCVKLSKFETEHSISFIPPDGEFELMRYRTTKDISLPFRVIPLVREVGRTKMEVKVVLKSN 312
            |||||||:|.:||.||.|:|||||||.|||.||:.::|::|||::|:|.::.:.|:..::.::::
pombe   259 CQFHQCVRLPEFENEHRITFIPPDGEVELMSYRSHENINIPFRIVPIVEQLSKQKIIYRISIRAD 323

  Fly   313 FKPSLLGQKIEVKIPTPLNTSGVQLICLKGKAKYKASENAIVWKIKRMAGMKETQLSAEIELLET 377
            : |..|...:..:||.|.|.........:|||.|:.|||.|.|||.|..|..|....||:||..|
pombe   324 Y-PHKLSSSLNFRIPVPTNVVKANPRVNRGKAGYEPSENIINWKIPRFLGETELIFYAEVELSNT 387

  Fly   378 DTKKKWTRPPISMNFEV-PFAPSGFKVRYLKVFEPKLNYSDHDVVKWVRYIGRSGLYETR 436
            ..::.|.:||||::|.: .|..||..|:||:|.||  :.|.:..:|||||..|:|..|.|
pombe   388 TNQQIWAKPPISLDFNILMFTSSGLHVQYLRVSEP--SNSKYKSIKWVRYSTRAGTCEIR 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-2mu	NP_001163686.1	AP2_Mu_N	1..140	CDD:341440	48/144 (33%)
AP-2mu	NP_001163686.1	AP-2_Mu2_Cterm	166..436	CDD:271159	117/273 (43%)
apm4	NP_592921.1	Clat_adaptor_s	1..134	CDD:261170	47/133 (35%)
apm4	NP_592921.1	AP-2_Mu2_Cterm	175..445	CDD:271159	117/273 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	246	1.000	Domainoid score	I419
eggNOG	1	0.900	-	-		E1_KOG0938
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3000
Inparanoid	1	1.050	345	1.000	Inparanoid score	I490
OMA	1	1.010	-	-		QHG53686
OrthoFinder	1	1.000	-	-		FOG0003937
OrthoInspector	1	1.000	-	-		oto102133
orthoMCL	1	0.900	-	-		OOG6_102976
Panther	1	1.100	-	-	LDO	PTHR10529
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R62
SonicParanoid	1	1.000	-	-		X2710
TreeFam	1	0.960	-	-
	14	13.860