DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-2mu and dpy-23

DIOPT Version :9

Sequence 1:	NP_001163686.1	Gene:	AP-2mu / 42642	FlyBaseID:	FBgn0263351	Length:	437	Species:	Drosophila melanogaster
Sequence 2:	NP_741770.1	Gene:	dpy-23 / 180713	WormBaseID:	WBGene00001082	Length:	441	Species:	Caenorhabditis elegans

Alignment Length:	445	Identity:	363/445 - (81%)
Similarity:	399/445 - (89%)	Gaps:	12/445 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIGGLFVYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHIKRANIWL 65
            ||||||||||||||||||:||||:.||||||||||||||||||||||||:|||||||:||.|:|:
Worm     1 MIGGLFVYNHKGEVLISRIYRDDVTRNAVDAFRVNVIHARQQVRSPVTNMARTSFFHVKRGNVWI 65

  Fly    66 AAVTKQNVNAAMVFEFLLKIIEVMQSYFGKISEENIKNNFVLIYELLDEILDFGYPQNTDSGTLK 130
            .|||:||||||||||||.:..:.|||||||::|||:||||||||||||||||||||||||.|.||
Worm    66 CAVTRQNVNAAMVFEFLKRFADTMQSYFGKLNEENVKNNFVLIYELLDEILDFGYPQNTDPGVLK 130

  Fly   131 TFITQQGIKSA------TKEEQMQITSQVTGQIGWRREGIKYRRNELFLDVLEYVNLLMSPQGQV 189
            |||||||:::|      |||||.||||||||||||||||||||||||||||:|||||||:.||||
Worm   131 TFITQQGVRTADAPVPVTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVIEYVNLLMNQQGQV 195

  Fly   190 LSAHVAGKVVMKSYLSGMPECKFGINDKIVMESKGRGLSGNSEAETSRSGKPVVVIDDCQFHQCV 254
            |||||||||.|||||||||||||||||||.:|.|.:..|.    :.:::.:..|.||||||||||
Worm   196 LSAHVAGKVAMKSYLSGMPECKFGINDKITIEGKSKPGSD----DPNKASRAAVAIDDCQFHQCV 256

  Fly   255 KLSKFETEHSISFIPPDGEFELMRYRTTKDISLPFRVIPLVREVGRTKMEVKVVLKSNFKPSLLG 319
            ||:||||||:|||||||||:|||||||||||.||||||||||||.|.|||||||:|||||||||.
Worm   257 KLTKFETEHAISFIPPDGEYELMRYRTTKDIQLPFRVIPLVREVSRNKMEVKVVVKSNFKPSLLA 321

  Fly   320 QKIEVKIPTPLNTSGVQLICLKGKAKYKASENAIVWKIKRMAGMKETQLSAEIELLETDT--KKK 382
            ||:||:||||.|||||||||:||||||||.||||||||||||||||:|:||||:||.|..  |||
Worm   322 QKLEVRIPTPPNTSGVQLICMKGKAKYKAGENAIVWKIKRMAGMKESQISAEIDLLSTGNVEKKK 386

  Fly   383 WTRPPISMNFEVPFAPSGFKVRYLKVFEPKLNYSDHDVVKWVRYIGRSGLYETRC 437
            |.|||:||||||||||||.|||||||||||||||||||:||||||||||||||||
Worm   387 WNRPPVSMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIKWVRYIGRSGLYETRC 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-2mu	NP_001163686.1	AP2_Mu_N	1..140	CDD:341440	116/138 (84%)
AP-2mu	NP_001163686.1	AP-2_Mu2_Cterm	166..436	CDD:271159	220/271 (81%)
dpy-23	NP_741770.1	Clat_adaptor_s	1..126	CDD:261170	105/124 (85%)
dpy-23	NP_741770.1	AP-2_Mu2_Cterm	172..440	CDD:271159	220/271 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159329
Domainoid	1	1.000	473	1.000	Domainoid score	I211
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3000
Inparanoid	1	1.050	739	1.000	Inparanoid score	I305
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53686
OrthoDB	1	1.010	-	-		D274992at33208
OrthoFinder	1	1.000	-	-		FOG0003937
OrthoInspector	1	1.000	-	-		oto18646
orthoMCL	1	0.900	-	-		OOG6_102976
Panther	1	1.100	-	-	LDO	PTHR10529
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R62
SonicParanoid	1	1.000	-	-		X2710
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940