Protein Alignment AP-2mu and unc-101

DIOPT Version :10

• Sequence 1: NP_651049.3
• Gene: AP-2mu / 42642
• FlyBaseID: FBgn0263351
• Length: 437
• Species: Drosophila melanogaster
• Sequence 2: NP_001040675.1
• Gene: unc-101 / 173121
• WormBaseID: WBGene00006829
• Length: 422
• Species: Caenorhabditis elegans
• Alignment Length: 437
• Identity: 177/437 - (40%)
• Similarity: 258/437 - (59%)
• Gaps: 27/437 - (6%)

  Fly     5 LFVYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRS--PVTNIARTSFFHIKRANIWLAA 67
            :|:.:.||:.:|||.||.||...|:|.| ::::..:::..|  ||.....|:|..||..||:|.:
 Worm     6 MFILDLKGKTIISRNYRGDIDMTAIDKF-IHLLMEKEEEGSAAPVLTYQDTNFVFIKHTNIYLVS 69

  Fly    68 VTKQNVNAAMVFEFLLKIIEVMQSYFGKISEENIKNNFVLIYELLDEILDFGYPQNTDSGTLKTF 132
            ..:.|||..|:..||.|.:||...||..:.||::::|||:|||||||::|||:||.|:|..|:.:
 Worm    70 ACRSNVNVTMILSFLYKCVEVFSEYFKDVEEESVRDNFVVIYELLDEMMDFGFPQTTESRILQEY 134

  Fly   133 ITQQGIK--SATKEEQMQITSQVTGQIGWRREGIKYRRNELFLDVLEYVNLLMSPQGQVLSAHVA 195
            |||:|.|  ||.:...     .||..:.||.||||||:||:||||:|.||:|.|..|.||.:.:.
 Worm   135 ITQEGQKLISAPRPPM-----AVTNAVSWRSEGIKYRKNEVFLDVIESVNMLASANGTVLQSEIV 194

  Fly   196 GKVVMKSYLSGMPECKFGINDKIVMESKGRGLSGNSEAETSRSGKPVVVIDDCQFHQCVKLSKFE 260
            |.|.|:.||:||||.:.|:|||::.|..|||.|.:.|            ::|.:|||||:||:|:
 Worm   195 GSVKMRVYLTGMPELRLGLNDKVLFEGSGRGKSKSVE------------LEDVKFHQCVRLSRFD 247

  Fly   261 TEHSISFIPPDGEFELMRYRTTKDISLPFRVIPLVREVGRTKMEVKVVLKSNFKPSLLGQKIEVK 325
            |:.:||||||||.||||.||.|..:.....:...:.....:::...:..||.||.......:|:.
 Worm   248 TDRTISFIPPDGAFELMSYRLTTVVKPLIWIETSIERHSHSRVSFIIKAKSQFKRRSTANNVEII 312

  Fly   326 IPTPLNTSGVQLICLKGKAKYKASENAIVWKIKRMAGMKETQLSAEIELLETDTKKKWTRPPISM 390
            ||.|.:....:.....|..||...::|.||.||...|.||..|:|.:.|....:::...||||.:
 Worm   313 IPVPSDADSPKFKTSIGSVKYTPEQSAFVWTIKNFPGGKEYLLTAHLSLPSVMSEESEGRPPIKV 377

  Fly   391 NFEVP-FAPSGFKVRYLKVFEPKLNYSDHDVVKWVRYIGRSGLYETR 436
            .||:| |..||.:|||||:.|.    |.:..:.|||||.::|.||.|
 Worm   378 KFEIPYFTTSGIQVRYLKIIEK----SGYQALPWVRYITQNGEYEMR 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-2mu	NP_651049.3	AP2_Mu_N	1..140	CDD:341440	59/138 (43%)
		AP-2_Mu2_Cterm	166..436	CDD:271159	107/270 (40%)
unc-101	NP_001040675.1	AP1_Mu_N	4..142	CDD:341439	58/136 (43%)
		AP-1_Mu1A_Cterm	152..421	CDD:271166	116/285 (41%)