Protein Alignment AP-2mu and Ap4m1

DIOPT Version :10

• Sequence 1: NP_651049.3
• Gene: AP-2mu / 42642
• FlyBaseID: FBgn0263351
• Length: 437
• Species: Drosophila melanogaster
• Sequence 2: XP_006504614.1
• Gene: Ap4m1 / 11781
• MGIID: 1337063
• Length: 463
• Species: Mus musculus
• Alignment Length: 482
• Identity: 133/482 - (27%)
• Similarity: 224/482 - (46%)
• Gaps: 66/482 - (13%)

  Fly     1 MIGGLFVYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIA--------RT---- 53
            ||...|:.:.||:.||.:.:|.|.|...|.......:.......|||..:.        ||
Mouse     1 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGGESPVVMVTTVVGVQGLRTVEYH 65

  Fly    54 ---SFFHIKRANIWLAAVTKQNVNAAMVFEFLLKIIEVMQSYFGKISEENIKNNFVLIYELLDEI 115
               .|.||:.:.::|.|.|.:||:...:.|.|.::..::..|.|.::|..|..|..|:||||||:
Mouse    66 GDRHFIHIRHSGLYLVATTLENVSPFSLLELLSRLATLLGDYCGSLNEGTISRNVALVYELLDEV 130

  Fly   116 LDFGYPQNTDSGTLKTFITQQGIKS----------------ATKEEQMQITSQVTGQIGWRREGI 164
            ||:||.|.|.:..|:.||..:.:.|                .|::.::..:|..:..:...|..
Mouse   131 LDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQNKVAPSSAASRPVLSSRSD- 194

  Fly   165 KYRRNELFLDVLEYVNLLMSPQGQVLSAHVAGKVVMKSYLSGMPECKFGINDKIVMESKGRGLSG 229
            :.::||:||||:|.:::|::..|.:|...|.|::.:||:|....|...|:.::..:        |
Mouse   195 QSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEICIGLTEEFCV--------G 251

  Fly   230 NSEAETSRSGKPVVVIDDCQFHQCVKLSKFETEHSISFIPPDGEFELMRYRTTKDI--SLPFRVI 292
            .||.   |...|.:.:|:..||..|.|.:||:...:...||.||..:|||:.:.|:  .||||:.
Mouse   252 KSEL---RGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLF 313

  Fly   293 PLVR-EVGRTKMEVKVVLKSNFKPSLLGQKIEVKIPTPLNTSGVQLICLKGKAKYKASENAIVWK 356
            |.|: :.|..:::|.:.|:.:..|......|.:.:|.|.....:.........|.:..|.|:.|.
Mouse   314 PSVQWDQGSGRLQVYLKLRCDLPPKSQALNIHLHLPLPRGVISLSQELSSPDQKAELGEGALHWD 378

  Fly   357 IKRMAGMKETQLSAEIELLETDTKKKWTRP----------PISMNFEVP-FAPSGFKVRYLKV-F 409
            :.|:.|  .:|||.   |.:.|.......|          |.|::||:| ...||.:||:|:: |
Mouse   379 LPRVQG--GSQLSG---LFQMDVPGLQGLPNHGPSPLGLGPASLSFELPRHTCSGLQVRFLRLSF 438

  Fly   410 EPKLNYSDHDVVKWVRYIGRSGLYETR 436
            ....|.:.|   ||||::..|..|..|
Mouse   439 SACGNANPH---KWVRHLSHSNAYVIR 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-2mu	NP_651049.3	AP2_Mu_N	1..140	CDD:341440	47/153 (31%)
		AP-2_Mu2_Cterm	166..436	CDD:271159	81/284 (29%)
Ap4m1	XP_006504614.1	AP4_Mu_N	3..155	CDD:341442	45/151 (30%)
		AP-4_Mu4_Cterm	189..463	CDD:271161	83/294 (28%)