Protein Alignment AP-2mu and AP1M2

DIOPT Version :10

• Sequence 1: NP_651049.3
• Gene: AP-2mu / 42642
• FlyBaseID: FBgn0263351
• Length: 437
• Species: Drosophila melanogaster
• Sequence 2: NP_001287816.1
• Gene: AP1M2 / 10053
• HGNCID: 558
• Length: 425
• Species: Homo sapiens
• Alignment Length: 434
• Identity: 165/434 - (38%)
• Similarity: 262/434 - (60%)
• Gaps: 18/434 - (4%)

  Fly     5 LFVYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQ-VRSPVTNIARTSFFHIKRANIWLAAV 68
            :|:.:.||:.||||.|:.|:..:.::.|...::...:: ..:|:.:..:..|..||.:|::|.|.
Human     6 VFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWIKHSNLYLVAT 70

  Fly    69 TKQNVNAAMVFEFLLKIIEVMQSYFGKISEENIKNNFVLIYELLDEILDFGYPQNTDSGTLKTFI 133
            |.:|.||::|:.||.|.|||...||.::.||:|::|||::||||||::|||:||.|||..|:.:|
Human    71 TSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDFGFPQTTDSKILQEYI 135

  Fly   134 TQQGIKSATKEEQMQITSQVTGQIGWRREGIKYRRNELFLDVLEYVNLLMSPQGQVLSAHVAGKV 198
            |||..|..|.:.::..|  ||..:.||.|||||::||:|:||:|.||||::..|.||.:.:.|.:
Human   136 TQQSNKLETGKSRVPPT--VTNAVSWRSEGIKYKKNEVFIDVIESVNLLVNANGSVLLSEIVGTI 198

  Fly   199 VMKSYLSGMPECKFGINDKIVMESKGRGLSGNSEAETSRSGKPVVVIDDCQFHQCVKLSKFETEH 263
            .:|.:||||||.:.|:||:::.|..|...|.|...|          ::|.:|||||:||:|:.:.
Human   199 KLKVFLSGMPELRLGLNDRVLFELTGLSGSKNKSVE----------LEDVKFHQCVRLSRFDNDR 253

  Fly   264 SISFIPPDGEFELMRYRTTKDISLPFRVIPLVREVGRTKMEVKVVLKSNFKPSLLGQKIEVKIPT 328
            :||||||||:||||.||.:..:.....:..::.:...:::|:.|..|..||...:...:|:.:|.
Human   254 TISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMVKAKGQFKKQSVANGVEISVPV 318

  Fly   329 PLNTSGVQLICLKGKAKYKASENAIVWKIKRMAGMKETQLSAEIELLETDTKKKWTRPPISMNFE 393
            |.:....:.....|.|||....|.::|.||...|.||..:.|...|...:.::...||||.:.||
Human   319 PSDADSPRFKTSVGSAKYVPERNVVIWSIKSFPGGKEYLMRAHFGLPSVEKEEVEGRPPIGVKFE 383

  Fly   394 VP-FAPSGFKVRYLKVFEPKLNYSDHDVVKWVRYIGRSGLYETR 436
            :| |..||.:|||:|:.|.    |.:..:.|||||.:||.|:.|
Human   384 IPYFTVSGIQVRYMKIIEK----SGYQALPWVRYITQSGDYQLR 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-2mu	NP_651049.3	AP2_Mu_N	1..140	CDD:341440	55/135 (41%)
		AP-2_Mu2_Cterm	166..436	CDD:271159	98/270 (36%)
AP1M2	NP_001287816.1	AP1_Mu_N	4..142	CDD:341439	55/135 (41%)
		AP_MHD_Cterm	154..423	CDD:472082	105/282 (37%)